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Curriculum Vitae


MAKLUMAT ASAS

DR. SAIFUL EFFENDI BIN SYAFRUDDIN

PENSYARAH UNIVERSITI
INSTITUT BIOLOGI MOLEKUL PERUBATAN UKM (UMBI)
effendisy@ppukm.ukm.edu.my
No.rasmi UKM : 03 8921 5555
BIOGRAFI /BIOGRAPHY


Saiful Effendi Syafruddin is a Research Fellow/Senior Lecturer at the UKM Medical Molecular Biology Institute (UMBI). He holds PhD in Medical Sciences from the University of Cambridge, UK. He previously earned his Master’s in Biotechnology (Molecular Genetic) from the University of Pennsylvania, USA, and BSc. in Biotechnology from Rochester Institute of Technology, USA. His PhD project focused on elucidating the genetic and epigenetic determinants that support kidney cancer pathogenesis. Saiful Effendi research interest revolves around understanding cancer molecular dependencies, specifically in kidney cancer, with the aim to identify novel and efficient clinical strategies to fight against cancer. Having been trained in the field of cell and molecular biology, cancer biology and genetic engineering for more than a decade, he has been extensively utilizing various state-of-the-art laboratory techniques throughout his cancer research works. Several of his research works have been published in high impact journals such as Nature, Cancer Discovery, Nature Communication, and Cell.

KELAYAKAN AKADEMIK / ACADEMIC QUALIFICATION
(Bidang Pengajian),(Peringkat),(Institusi),(Tahun)
Medical Science , Doktor Falsafah , UNIVERSITY OF CAMBRIDGE, UNITED KINGDOM , 2019
Sarjana , University of Pennsylvania , 2011
BIOTEKNOLOGI , Sarjana Muda , Rochester Institute of Technology , 2009
KEPAKARAN / EXPERTISE
PURE AND APPLIED SCIENCES - BIOLOGY (Cellular and Molecular Biology, Genomics, Genetic Engineering)
CLINICAL AND HEALTH SCIENCES - BASIC MEDICAL SCIENCES (Cancer Biology)
CLINICAL AND HEALTH SCIENCES - BASIC MEDICAL SCIENCES (Cancer Genetic and Epigenetic)
CLINICAL AND HEALTH SCIENCES - BASIC MEDICAL SCIENCES (Recombinant DNA technology and gene targeting)
PENERBITAN TERKINI / LATEST PUBLICATION

Penerbitan Berimpak Tinggi

Alyssa Zi-xin Leong, Pey Yee Lee, M. Aiman Mohtar, Saiful Effendi Syafruddin, Yuh-fen Pung And Teck Yew Low.  (2022).  Short Open Reading Frames (sorfs) And Microproteins: An Update On Their Identification And Validation Measures.  - Journal Of Biomedical Science.  1-15. 
Rashidah Baharudin, Muhiddin Ishak, Azliana Muhamad Yusof, Sazuita Saidin, Saiful Effendi Syafruddin, Wan Fahmi Wan Mohamad Nazarie, Learn-han Lee, Nurul-syakima Ab Mutalib.  (2022).  Epigenome-wide Dna Methylation Profiling In Colorectal Cancer And Normal Adjacent Colon Using Infinium Human Methylation 450k.  - Diagnostics.  1-22. 
Nisa Syakila A. Rahman, Syazalina Zahari, Saiful Effendi Syafruddin, Mohd Firdaus-raih, Teck Yew Low, M. Aiman Mohtar.  (2022).  Functions And Mechanisms Of Protein Disulfide Isomerase Family In Cancer Emergence.  - Cell & Bioscience.  1-19. 
Asmaa Y. Abuhamad, Nurul Nadia Mohamad Zamberi, Ling Sheen, Safaa M. Naes, Siti Nur Hasanah Mohd Yusuf, Asilah Ahmad Tajudin, M. Aiman Mohtar, Amir Syahir Amir Hamzah, Saiful Effendi Syafruddin.  (2022).  Reverting Tp53 Mutation In Breast Cancer Cells: Prime Editing Workflow And Technical Considerations.  - Cells.  1-16. 
Saroor A. Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K. Richardson, Jianfeng Ge, Saiful E. Syafruddin, Alyson Speed, Evangelia K. Papachristou, David Baker, David Clarke, Ludovic Wesolowski, , Jason S. Carroll, Sakari Vanharanta.  (2022).  The Renal Lineage Factor Pax8 Controls Oncogenic Signalling In Kidney Cancer.  - Nature.  999-1006. 
Poh Kuan Wong, Fook Choe Cheah, Saiful Effendi Syafruddin, M Aiman Mohtar, Norazrina Azmi, Pei Yuen Ng, Eng Wee Chua.  (2021).  Crispr Gene-editing Models Geared Toward Therapy For Hereditary And Developmental Neurological Disorders.  - Frontiers In Pediatrics.  1-15. 
Saiful Effendi Syafruddin , Sheen Ling, Teck Yew Low And M Aiman Mohtar.  (2021).  More Than Meets The Eye: Revisiting The Roles Of Heat Shock Factor 4 In Health And Diseases.  - Biomolecules.  1-18. 
Teck Yew Low, Saiful Effendi Syafruddin, M. Aiman Mohtar, Adaikkalam Vellaichamy, Nisa Syakila A Rahman, Yuh-fen Pung & Chris Soon Heng Tan.  (2021).  Recent Progress In Mass Spectrometry-based Strategies For Elucidating Protein-protein Interactions.  - Cellular And Molecular Life Sciences.  5325-5339. 
Malak Hassn Mesrati, Saiful Effendi Syafruddin, M. Aiman Mohtar, Amir Syahir.  (2021).  Cd44: A Multifunctional Mediator Of Cancer Progression.  - Biomolecules.  1-32. 
M. Aiman Mohtar, Saiful Effendi Syafruddin, Siti Nurmi Nasir, Low Teck Yew.  (2020).  Revisiting The Roles Of Pro-metastatic Epcam In Cancer.  - Biomolecules.  1-19. 
Saiful E. Syafruddin, M. Aiman Mohtar, Wan Fahmi Wan Mohamad Nazarie, Teck Yew Low.  (2020).  Two Sides Of The Same Coin: The Roles Of Klf6 In Physiology And Pathophysiology.  - Biomolecules.  1-22. 
Saiful E. Syafruddin, Paulo Rodrigues, Erika Vojtasova, Saroor A. Patel, M. Nazhif Zaini, Johanna Burge, Anne Y. Warren, Grant D. Stewart, Tim Eisen, Dora Bihary, Shamith A. Samarajiwa, Sakari Vanharanta.  (2019).  A Klf6-driven Transcriptional Network Links Lipid Homeostasis And Tumour Growth In Renal Carcinoma.  - Nature Communication.  1-13. 
Siti Syazani Suhaimi, Nurul-syakima Ab Mutalib, Sheau S. Khor, Reena Rahayu Md Zain, Saiful Effendi Syafruddin, Nadiah Abu, Ahmad Zailani Hatta Mohd Dali And Rahman Jamal.  (2018).  Targeted Next-generation Sequencing Identifies Actionable Targets In Estrogen Receptor Positive And Estrogen Receptor Negative Endometriod Endometrial Cancer.  - Frontiers In Pharmacology. 
M. Nazhif Zaini, Saroor A. Patel, Saiful E. Syafruddin, Paulo Rodrigues & Sakari Vanharanta.  (2018).  Endogenous Hif2a Reporter Systems For High-throughput Functional Screening.  - Scientific Reports. 
Paulo Rodrigues, Saroor A. Patel, Louise Harewood, Ioana Olan, Erika Vojtasova, Saiful E. Syafruddin, M. Nazhif Zaini, Emma K. Richardson, Johanna Burge, Anne Y. Warren, Grant D. Stewart, Kourosh Saeb-parsy, Shamith A Samarajiwa, And Sakari Vanharanta.  (2018).  Nf-jb-dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis.  - Cancer Discovery. 
Shafina Nadiawati Abdul, Nurul Syakima Ab Mutalib, Khor S. Sean, Saiful E. Syafruddin, Muhiddin Ishak, Ismail Sagap, Luqman Mazlan, Isa M. Rose, Nadiah Abu, Norfilza M. Mokhtar And Rahman Jamal.  (2017).  Molecular Characterization Of Somatic Alterations In Dukes B And C Colorectal Cancers By Targeted Sequencing.  - Frontiers In Pharmacology.  1-19. 
Noraidatulakma Abdullah, Nor Azian Abdul Murad, Ezanee Azlina Mohd Haniff, Saiful Effendi Syafruddin, John Attia, Christopher Oldmeadow, Mohd Arman Kamaruddin, Nazihah Abd Jalal, Norliza Ismail, Muhiddin Ishak, Rahman Jamal, Rodney J. Scott, Elizabeth Gh.  (2017).  Predicting Type 2 Diabetes Using Genetic And Environmental Risk Factors In A Multi-ethnic Malaysian Cohort.  - Public Health.  31-38. 
Nf Mohamad Pakarul Razy, Na Abdul Murad, Se Syafruddin, A Ahmad-annuar, Sy Lim, Nm Ibrahim, R Jamal.  (2015).  Glucocerebrosidase Mutations In Malay Parkinson`s Disease Patients.  - Public Health Genomics.  23. 
N Abdullah, Na Abdul Murad, J Attia, C Oldmeadow, Ea Mohd Haniff, Se Syafruddin, N Abd Jalal, N Ismail, M Ishak, R Jamal, Rj Scott And Eg Holliday.  (2015).  Characterizing The Genetic Risk For Type 2 Diabetes In A Malaysian Multi-ethnic Cohort.  - Diabetic Medicine.  1377-1384. 
Fateen Farhana Ibrahim, Rahman Jamal, Saiful Effendi Syafruddin, Nurul Syakima Ab Mutalib, Sazuita Saidin, Reena Rahayu Mdzin, Mohammad Manir Hossain Mollah, Norfilza Mohd Mokhtar.  (2015).  Microrna-200c And Microrna-31 Regulate Proliferation, Colony Formation, Migration And Invasion In Serous Ovarian Cancer..  - Journal Of Ovarian Research.  1-14. 
Nurul-syakima Ab Mutalib, Saiful Effendi Syafruddin, Reena Rahayu Md Zain, Ahmad Zailani Hatta Mohd Dali, Ryia Illani Mohd Yunos, Sazuita Saidin, Rahman Jamal And Norfilza M Mokhtar.  (2014).  Molecular Characterization Of Serous Ovarian Carcinoma Using A Multigene Next Generation Sequencing Cancer Panel Approach.  - Bmc Research Notes.  1-10. 

Penerbitan WOS

Saiful Effendi Syafruddin, Wan Fahmi Wan Mohamad Nazarie, Nurshahirah Ashikin Moidu, Bee Hong Soon, M. Aiman Mohtar.  (2021).  Integration Of Rna-seq And Proteomics Data Identifies Glioblastoma Multiforme Surfaceome Signature.  - Bmc Cancer.  1-13. 
Nur Fadhlina Mohamad Pakarulrazy, Saiful Effendi Syafruddin, Nurul Syakima Ab Mutalib, Azlina Ahmad Annuar, Shen Yang Lim, Rahman Jamal, Nor Azian Abdul Murad, Norlinah Mohamed Ibrahim.  (2020).  Glucocerebrosidase Genetic Variants In Malays With Early And Late-onset Parkinson's Disease.  - Neurology Asia.  39-46. 

Penerbitan SCOPUS/ERA

Alyssa Zi-xin Leong, Pey Yee Lee, M. Aiman Mohtar, Saiful Effendi Syafruddin, Yuh-fen Pung And Teck Yew Low.  (2022).  Short Open Reading Frames (sorfs) And Microproteins: An Update On Their Identification And Validation Measures.  - Journal Of Biomedical Science.  1-15. 
Saroor A. Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K. Richardson, Jianfeng Ge, Saiful E. Syafruddin, Alyson Speed, Evangelia K. Papachristou, David Baker, David Clarke, Ludovic Wesolowski, , Jason S. Carroll, Sakari Vanharanta.  (2022).  The Renal Lineage Factor Pax8 Controls Oncogenic Signalling In Kidney Cancer.  - Nature.  999-1006. 
Rashidah Baharudin, Muhiddin Ishak, Azliana Muhamad Yusof, Sazuita Saidin, Saiful Effendi Syafruddin, Wan Fahmi Wan Mohamad Nazarie, Learn-han Lee, Nurul-syakima Ab Mutalib.  (2022).  Epigenome-wide Dna Methylation Profiling In Colorectal Cancer And Normal Adjacent Colon Using Infinium Human Methylation 450k.  - Diagnostics.  1-22. 
Nisa Syakila A. Rahman, Syazalina Zahari, Saiful Effendi Syafruddin, Mohd Firdaus-raih, Teck Yew Low, M. Aiman Mohtar.  (2022).  Functions And Mechanisms Of Protein Disulfide Isomerase Family In Cancer Emergence.  - Cell & Bioscience.  1-19. 
Siti Nur Hasanah Mohd Yusuf, Asmaa Y. Abuhamad, Ling Sheen, Nurul Nadia Zamberi, Mohamad Aimanuddin Mohtar, Saiful Effendi Syafruddin.  (2022).  Pdgfb Paracrine Signalling Fuels Growth Promoting-mtorc1 Hyperactivation In Clear Cell Renal Cell Carcinoma (ccrcc).  - Malaysian Journal Of Medicine And Health Sciences.  46. 
Asmaa Y. Abuhamad, Nurul Nadia Mohamad Zamberi, Ling Sheen, Safaa M. Naes, Siti Nur Hasanah Mohd Yusuf, Asilah Ahmad Tajudin, M. Aiman Mohtar, Amir Syahir Amir Hamzah, Saiful Effendi Syafruddin.  (2022).  Reverting Tp53 Mutation In Breast Cancer Cells: Prime Editing Workflow And Technical Considerations.  - Cells.  1-16. 
Poh Kuan Wong, Fook Choe Cheah, Saiful Effendi Syafruddin, M Aiman Mohtar, Norazrina Azmi, Pei Yuen Ng, Eng Wee Chua.  (2021).  Crispr Gene-editing Models Geared Toward Therapy For Hereditary And Developmental Neurological Disorders.  - Frontiers In Pediatrics.  1-15. 
Saiful Effendi Syafruddin , Sheen Ling, Teck Yew Low And M Aiman Mohtar.  (2021).  More Than Meets The Eye: Revisiting The Roles Of Heat Shock Factor 4 In Health And Diseases.  - Biomolecules.  1-18. 
Nisa Syakila A Rahman, Teck Yew Low, Saiful Effendi Syafruddin, M. Aiman Mohtar.  (2021).  Functional Interrogation Of Crispr-cas9 Mediated Agr2 Knockout In Metastatic Triple Negative Breast Cancer Cells.  - Asm Science Journal.  91. 
Malak Hassn Mesrati, Saiful Effendi Syafruddin, M. Aiman Mohtar, Amir Syahir.  (2021).  Cd44: A Multifunctional Mediator Of Cancer Progression.  - Biomolecules.  1-32. 
Saiful Effendi Syafruddin, Wan Fahmi Wan Mohamad Nazarie, Nurshahirah Ashikin Moidu, Bee Hong Soon, M. Aiman Mohtar.  (2021).  Integration Of Rna-seq And Proteomics Data Identifies Glioblastoma Multiforme Surfaceome Signature.  - Bmc Cancer.  1-13. 
Asmaa Y. I. Abuhamad, Mohamad Aimanuddin Mohtar, Asilah Ahmad Tajudin, Amir Syahir Amir Hamzah, Saiful Effendi Syafruddin.  (2021).  Crispr-mediated Generation Of In Vitro Breast Cancer Models To Study P53 Gain Of Function Mutation.  - Asia Pacific Journal Of Molecular Biology & Biotechnology.  1. 
Teck Yew Low, Saiful Effendi Syafruddin, M. Aiman Mohtar, Adaikkalam Vellaichamy, Nisa Syakila A Rahman, Yuh-fen Pung & Chris Soon Heng Tan.  (2021).  Recent Progress In Mass Spectrometry-based Strategies For Elucidating Protein-protein Interactions.  - Cellular And Molecular Life Sciences.  5325-5339. 
M. Aiman Mohtar, Saiful Effendi Syafruddin, Siti Nurmi Nasir, Low Teck Yew.  (2020).  Revisiting The Roles Of Pro-metastatic Epcam In Cancer.  - Biomolecules.  1-19. 
Nurshahirah Ashikin Moidu, Nisa Syakila A Rahman, Saiful Effendi Syafruddin, Teck Yew Low, M. Aiman Mohtar.  (2020).  Secretion Of Pro-oncogenic Agr2 Protein In Cancer.  - Heliyon.  1-11. 
Saiful E. Syafruddin, M. Aiman Mohtar, Wan Fahmi Wan Mohamad Nazarie, Teck Yew Low.  (2020).  Two Sides Of The Same Coin: The Roles Of Klf6 In Physiology And Pathophysiology.  - Biomolecules.  1-22. 
Nur Fadhlina Mohamad Pakarulrazy, Saiful Effendi Syafruddin, Nurul Syakima Ab Mutalib, Azlina Ahmad Annuar, Shen Yang Lim, Rahman Jamal, Nor Azian Abdul Murad, Norlinah Mohamed Ibrahim.  (2020).  Glucocerebrosidase Genetic Variants In Malays With Early And Late-onset Parkinson's Disease.  - Neurology Asia.  39-46. 
Saiful E. Syafruddin, Paulo Rodrigues, Erika Vojtasova, Saroor A. Patel, M. Nazhif Zaini, Johanna Burge, Anne Y. Warren, Grant D. Stewart, Tim Eisen, Dora Bihary, Shamith A. Samarajiwa, Sakari Vanharanta.  (2019).  A Klf6-driven Transcriptional Network Links Lipid Homeostasis And Tumour Growth In Renal Carcinoma.  - Nature Communication.  1-13. 
Siti Syazani Suhaimi, Nurul-syakima Ab Mutalib, Sheau S. Khor, Reena Rahayu Md Zain, Saiful Effendi Syafruddin, Nadiah Abu, Ahmad Zailani Hatta Mohd Dali And Rahman Jamal.  (2018).  Targeted Next-generation Sequencing Identifies Actionable Targets In Estrogen Receptor Positive And Estrogen Receptor Negative Endometriod Endometrial Cancer.  - Frontiers In Pharmacology. 
M. Nazhif Zaini, Saroor A. Patel, Saiful E. Syafruddin, Paulo Rodrigues & Sakari Vanharanta.  (2018).  Endogenous Hif2a Reporter Systems For High-throughput Functional Screening.  - Scientific Reports. 
Paulo Rodrigues, Saroor A. Patel, Louise Harewood, Ioana Olan, Erika Vojtasova, Saiful E. Syafruddin, M. Nazhif Zaini, Emma K. Richardson, Johanna Burge, Anne Y. Warren, Grant D. Stewart, Kourosh Saeb-parsy, Shamith A Samarajiwa, And Sakari Vanharanta.  (2018).  Nf-jb-dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis.  - Cancer Discovery. 
Shafina Nadiawati Abdul, Nurul Syakima Ab Mutalib, Khor S. Sean, Saiful E. Syafruddin, Muhiddin Ishak, Ismail Sagap, Luqman Mazlan, Isa M. Rose, Nadiah Abu, Norfilza M. Mokhtar And Rahman Jamal.  (2017).  Molecular Characterization Of Somatic Alterations In Dukes B And C Colorectal Cancers By Targeted Sequencing.  - Frontiers In Pharmacology.  1-19. 
Noraidatulakma Abdullah, Nor Azian Abdul Murad, Ezanee Azlina Mohd Haniff, Saiful Effendi Syafruddin, John Attia, Christopher Oldmeadow, Mohd Arman Kamaruddin, Nazihah Abd Jalal, Norliza Ismail, Muhiddin Ishak, Rahman Jamal, Rodney J. Scott, Elizabeth Gh.  (2017).  Predicting Type 2 Diabetes Using Genetic And Environmental Risk Factors In A Multi-ethnic Malaysian Cohort.  - Public Health.  31-38. 
Nf Mohamad Pakarul Razy, Na Abdul Murad, Se Syafruddin, A Ahmad-annuar, Sy Lim, Nm Ibrahim, R Jamal.  (2015).  Glucocerebrosidase Mutations In Malay Parkinson`s Disease Patients.  - Public Health Genomics.  23. 
N Abdullah, Na Abdul Murad, J Attia, C Oldmeadow, Ea Mohd Haniff, Se Syafruddin, N Abd Jalal, N Ismail, M Ishak, R Jamal, Rj Scott And Eg Holliday.  (2015).  Characterizing The Genetic Risk For Type 2 Diabetes In A Malaysian Multi-ethnic Cohort.  - Diabetic Medicine.  1377-1384. 
Fateen Farhana Ibrahim, Rahman Jamal, Saiful Effendi Syafruddin, Nurul Syakima Ab Mutalib, Sazuita Saidin, Reena Rahayu Mdzin, Mohammad Manir Hossain Mollah, Norfilza Mohd Mokhtar.  (2015).  Microrna-200c And Microrna-31 Regulate Proliferation, Colony Formation, Migration And Invasion In Serous Ovarian Cancer..  - Journal Of Ovarian Research.  1-14. 
Nurul-syakima Ab Mutalib, Saiful Effendi Syafruddin, Reena Rahayu Md Zain, Ahmad Zailani Hatta Mohd Dali, Ryia Illani Mohd Yunos, Sazuita Saidin, Rahman Jamal And Norfilza M Mokhtar.  (2014).  Molecular Characterization Of Serous Ovarian Carcinoma Using A Multigene Next Generation Sequencing Cancer Panel Approach.  - Bmc Research Notes.  1-10. 

Bab Dalam Buku

Saiful Effendi Syafruddin, Mohamad Aimanuddin Mohtar, Tan Shing Cheng, Nadiah Abu, Nor Aidatulakma Abdullah@muda, Nurul Syakima Ab Mutalib, Chin Siok Fong, Neoh Hui Min, Rahman Jamal, Nor Azian Abdul Murad.  (2019).  Malaysian Higher Institution Centres Of Excellence (hicoe) Official Compendium.  - 244. 

Penerbitan Lain-lain

Nurainie Sayutti, Muhammad Azrai Abu, Saiful Effendi, Mohd Faizal Ahmad.  (2022).  Elucidating The Gene Expression Of Grem 1 In Cumulus Cells And Its Association With Oocytes Quality In Predicting Pregnancy Outcomes Among Pcos Women.  - Gynecological Endocrinology The 20th World Congress.  1. 
Low Teck Yew;mohd Firdaus Bin Mohd Raih;saiful Effendi Bin Syafruddin;mohamad Aimanuddin Bin Mohtar;lee Pey Yee.  (2022).  Elucidating The Mechanism Of Secretion For Human Pro-metastatic Agr2 Protein.  -
Saiful Effendi Bin Syafruddin, Encik Muhiddin Bin Ishak, Mohamad Aimanuddin Bin Mohtar.  (2022).  Elucidating The Mode Of Pdgfb-mediated Activation Of Mtorc1 Signalling Pathway In Clear Cell Renal Cell Carcinoma.  - 1-7. 
Syazalina Zahari , Saiful Effendi Syafruddin, Low Teck Yew , Delphine Fessart , Ted Hupp, M. Aiman Mohtar.  (2022).  Elucidating The Impact Of Crispr Cas9 Mediated Agr2 Knockout In The Tumour Microenvironment Of Breast Cancer Cells.  - The 46th Annual Conference Of The Malaysian Society For Biochemistry And Molecular Biology 2022 (msb.  1. 
Saiful Effendi Syafruddin.  (2022).  Cellular And Molecular Biology Of Cancer: Insights For Early Detection And Therapeutics.  - 1-27. 
Nurul Nadia Mohamad Zamberi, Asmaa Y. Abuhamad, Teck Yew Low, M. Aiman Mohtar, And Saiful Effendi Syafruddin.  (2022).  The Epigenetic Modulators Brd4 And P300 Support Klf6 Super Enhancer Activity In Promoting Renal Tumorigenesis.  - 46th Annual Conference Of The Malaysian Society For Biochemistry And Molecular Biology 2022 (msbmb46).  1-7. 
Saiful Effendi Syafruddin, Mohamad Aimanuddin Mohtar.  (2022).  Crispr-cas9 Principles, Applications And Ethical Issues.  - 1-61. 
Mohamad Aimanuddin Mohtar, Saiful Effendi Syafruddin.  (2022).  Protein Agr2: Bio Penanda Baru Untuk Pengesanan Awal Kanser.  - Impak: Kluster Kesihatan & Perubatan Termaju.  28-29. 
Saiful Effendi Syafruddin, Mohamad Aimanuddin Mohtar.  (2022).  Bengkel Crispr Gene Editing Di Institute Of Medical Research (imr).  - 1-3. 
Saiful Effendi Syafruddin, Mohamad Aimanuddin Mohtar.  (2022).  Crispr-cas9 Experimental Workflow Part Ii.  - 1-77. 
Saiful Effendi Syafruddin, Mohamad Aimanuddin Mohtar.  (2022).  Crispr-cas9 Experimental Workflow Part I.  - 1-81. 
Saiful Effendi Syafruddin.  (2021).  General Crispr Experimental Workflow And Case Studies.  - Emerging Technologies In Precision Medicine.  1-38. 
Asmaa Y. I. Abuhamad, Mohamad Aimanuddin Mohtar, Asilah Ahmad Tajudin, Amir Syahir Bin Amir Hamzah, Saiful Effendi Syafruddin.  (2021).  Crispr-mediated Generation Of In Vitro Breast Cancer Models To Study P53 Ain-of-function Mutation.  - 4th International Conference On Molecular Biology & Biotechnology.  1-19. 
Saiful Effendi Syafruddin.  (2021).  Genome Editing : Are We Ready For That?.  - 1-32. 
Siti Nur Hasanah Mohd. Yusof, Saiful Effendi Syafruddin.  (2021).  Pdgfb Paracrine Signalling Fuels Mtorc1 Hyperactivation In Ccrcc.  - 1-20. 
Nur Alyaa Afifah Md Shahri, Nur Nadia Razali & Saiful Effendi Syafruddin.  (2021).  The Importance Of Bioinformatics In Molecular Biology Research Part Ii: Network Analysis & Molecular Docking, Simulation.  - Website Umbi.  1. 
Nisa Syakila A Rahman, Saiful Effendi Syafruddin, Teck Yew Low, M. Aiman Mohtar.  (2021).  Functional Interrogation Of Crispr-cas9 Mediated Agr2 Knockout In Metastatic Triple Negative Breast Cancer Cells.  - Ysn-asm International Scientific Virtual Conference (isvc) 2021.  1. 
Poh Kuan Wong, Eng Wee Chua, Norazrina Azmi, Saiful Effendi Syafruddin, Martin Kennedy.  (2021).  Developing In Vitro Model Using Crispr Gene-editing System To Understand Caffeine Sensitivity In The Developing Brain.  - Pharmacy Research Day 2021.  59. 
Nazihah Abd Jalal, Norliza Ismail & Dr. Saiful Effendi Syafruddin.  (2021).  Hati Berlemak: Kesan Kepada Kesihatan.  - Website Umbi.  1. 
Siti Nur Hasanah Mohd Yusuf, Asmaa Y. Abuhamad, Ling Sheen, Nurul Nadia Zamberi, Mohamad Aimanuddin Mohtar And Saiful Effendi Syafruddin.  (2021).  Pdgfb Paracrine Signalling Fuels Growth Promoting Mtorc1 Hyperactivation In Clear Cell Renal Cell Carcinoma (ccrcc).  - International Conference On Drug Discovery And Translational Medicine 2021 (icddtm 21).  1-14. 
Asmaa Y. Abuhamad, Ling Sheen, Safaa M. Naes, Siti Nur Hasanah Yusuf, Nurul Nadia Zamberi, Asilah Ahmad Tajudin, Mohamad Aimanuddin Mohtar, Amir Syahir Bin Amir Hamzah, Saiful Effendi Syafruddin.  (2021).  Crispr Gene Editing The Generation Of Genetically Engineered Breast Cancer Cells For Interrogating The L194f P53 Mutation.  - International Conference On Drug Discovery And Translational Medicine 2021 (icddtm 21).  1-14. 
Saiful Effendi Syafruddin.  (2021).  The Interrogation Of Steroid Addiction In Renal Cancer.  - 1-20. 
Siti Nur Hasanah Mohd Yusuf, Mira Farzana Mohamad Mokhtar & Saiful Effendi Syafruddin.  (2021).  The Importance Of Bioinformatics In Molecular Biology Research Part I: Introduction To Bioinformatics & Rna-seq.  - Website Umbi.  1. 
Saiful Effendi Bin Syafruddin.  (2020).  Elucidating The Mode Of Pdgfb-mediated Activation Of Mtorc1 Signaling Pathway In Clear Cell Renal Cell Carcinoma.  - Makna Cancer Research Award 2019 Ceremony (mrca 2019).  1-14. 
Saiful Effendi Syafruddin.  (2020).  Investigating The Glucocorticoid Receptor Nr3c1 Role In Supporting Clear Cell Renal Cell Carcinoma Pathogenesis.  - 1. 
Saiful Effendi Syafruddin.  (2020).  Investigating The Glucocorticoid Receptor Nr3c1 Role In Supporting Clear Cell Renal Cell Carcinoma Pathogenesis.  - Celebrating The Legacy Of Dr Ranjeet Bhagwan Singh: Paradigm Shift In Medical Research.  1-7. 
Safaa M. Naes, Sharaniza Ab. Rahim, Musalmah Binti Mazlan, Saiful Effendi Syafruddin, M. Aiman Mohtar, Amirah Abdul Rahman.  (2020).  Ent2 Gene Expression In The Different Stages Of Colorectal Cancer.  - International E-conference On Biotechnology, Bioinformatics, And Biomedicine.  1. 
Saiful Effendi Syafruddin.  (2020).  Elucidating The Mode Of Pdgfb-mediated Activation Of Mtorc1 Signaling Pathway In Clear Cell Renal Cell Carcinoma.  - Makna Cancer Research Award 2019 Ceremony (mrca 2019).  1. 
Mohamad Aimanuddin Mohtar, Saiful Effendi Syafruddin, Amir Syahir Bin Amir Hamzah.  (2020).  Teknologi Penyuntingan Gen Crispr Dan Teknik Terbaharu Pengesanan Covid-19.  - Majalahsains.com.  1-2. 
Mohamad Aimanuddin Mohtar, Saiful Effendi Syafruddin,.  (2020).  Crispr Protocol For Crispr-mediated Gene Editing In Human Cell Lines Workshop 2019.  - 1-24. 
Saiful Effendi Bin Syafruddin, Paulo Rodrigues, Erika Vojtasova, Saroor Patel, Dora Bihary, Shamith Samarajiwa, Sakari Vanharanta.  (2018).  A Klf6-dependent Pdgfb-mtor Signaling Loop Links Lipid Homeostasis And Tumor Growth In Renal Cancer.  - Abcam Cancer And Metabolism 2018.  43. 
Siti Syazani Suhaimi, Nurul Syakima Ab Mutalib, Khor Sheau Sean, Saiful Effendi Syafruddin, Nadiah Abu, Reena Rahayu Md Zain, Ahmad Zailani Hatta Mohd Dali, Rahman Jamal.  (2017).  Elucidation Of Signal Transduction Pathways Involved In Molecular Subtypes Of Endometrial Cancer.  - 7th Regional Conference On Molecular Medicine (rcmm) In Conjunction With 3rd National Conference For Cancer Research 2017. 
Noraidatulakma Abdullah, Nor Azian Abdul Murad, Ezanee Azlina Mohd Haniff, Saiful Effendi Syafruddin, John Attia, Christopher Oldmeadow, Mohd Arman Kamaruddin, Nazihah Abd Jalal, Norliza Ismail, Muhiddin Ishak, Rodney J. Scott & Elizabeth Holliday.  (2017).  Genetic And Non-genetic Studies Of Type 2 Diabetes In The Multi-ethnic Malaysian Cohort.  - 7th Regional Conference On Molecular Medicine In Conjuction With 3rd National Conference For Cancer Research. 10th-12th November 2017, Kuala Lumpur, Malaysia.. 
Fateen Farhana Ibrahim, Saiful Effendi Syafruddin, Siti Aishah Mdali, Reena Mdzin, Rahman Jamal, Norfilza Mohd Mokhtar.  (2013).  Determining Micrornas Profile In Formalin-fxed Paraffin-embedded Samples Of Metastatic Serous Ovarian Cancer.  - 1st National Conference For Cancer Research & 5th Regional Conference On Molecular Medicine. 
PROJEK PENYELIDIKAN / RESEARCH PROJECT
(Tajuk),(Peranan),(Tempoh),(Tahap)

Aktif

Elucidating the functional link between proximal super enhancer locus and NR3C1 transcriptional regulation in clear cell renal cell carcinoma. , Ketua Projek , 01-03-2021 sehingga 28-02-2023 , Kebangsaan
Elucidating the upstream regulatory elements that support the super enhancer associated KLF6 expression in clear cell renal cell carcinoma (ccRCC). , Ketua Projek , 01-11-2020 sehingga 30-04-2024 , Kebangsaan
Functional validation of CRISPR-Cas9 genetic screening hit HSF4 in supporting clear cell renal cell carcinoma pathogenesis , Ketua Projek , 01-08-2020 sehingga 31-01-2023 , Universiti
CRISPR-based technologies for the identification of transcriptional regulatory elements in driving AGR2 gene overexpression in breast cancer , Penyelidik Bersama , 01-09-2022 sehingga 31-08-2025 , Kebangsaan
Evaluating directed encapsulation of CRISPR/Cas9 as self-assembled ribonucleoprotein (RNP) complex into exosomes for CD73 ablation as locally administered lung cancer immunotherapy , Penyelidik Bersama , 01-09-2022 sehingga 31-08-2025 , Kebangsaan
Elucidate cancer progression caused by faulty T cell receptor (TCR) signalling in Cdc42 C81Y-induced primary immunodeficiencies. , Penyelidik Bersama , 01-09-2022 sehingga 31-08-2024 , Kebangsaan
Incorporation of Metallic nanoparticles on Bragg Grating waveguide by utilizing Localized Surface Plasmon Resonance for volatile organic compound detection in covid-19 , Penyelidik Bersama , 01-09-2022 sehingga 31-08-2024 , Kebangsaan
Elucidating the GREM1, HAS2 and PTGS2 gene expression as oocytes development competency markers among women with poor ovarian reserve (POR) following the in vitro maturation (IVM) , Penyelidik Bersama , 07-09-2021 sehingga 06-09-2024 , Kebangsaan
INVESTIGATING THE EFFECT OF IDH2 MUTATION ON DNA MISMATCH REPAIR STATUS IN DRIVING MUTAGENESIS IN ACUTE MYELOID LEUKAEMIA , Penyelidik Bersama , 01-09-2021 sehingga 31-08-2023 , Kebangsaan
Comb structured wearable metamaterial with electrical conductivity for health monitoring garment of severe patients , Penyelidik Bersama , 01-09-2021 sehingga 31-08-2023 , Universiti
Elucidating The Gene Expression Of Grem1 In Cumulus Cells And Its Association With HOMA-IR Among PCOS Women , Penyelidik Bersama , 16-07-2021 sehingga 15-07-2023 , Universiti
Elucidating the endometrial HOXA 10 methylation alteration in infertility related endometriosis women following modulation of gonadotropin-releasing hormone receptor , Penyelidik Bersama , 01-11-2020 sehingga 30-04-2023 , Kebangsaan
Elucidating the microproteome uniquely expressed in cell lines derived from multiple stages of colorectal cancer (CRC) , Penyelidik Bersama , 01-08-2020 sehingga 31-07-2023 , Universiti
Elucidating the secretome of CRISPR/Cas9 mediated AGR2-knockout breast cancer cells , Penyelidik Bersama , 01-08-2020 sehingga 31-01-2023 , Antarabangsa
CRISPRi genetic screen in identifying surfaceome addiction in glioblastoma multiforme , Penyelidik Bersama , 01-01-2020 sehingga 31-12-2023 , Antarabangsa

Tamat

Investigating the glucocorticoid receptor NR3C1 role in supporting clear cell renal cell carcinoma (ccRCC) pathogenesis , Ketua Projek , 01-10-2020 sehingga 30-09-2022 , Kebangsaan
Elucidating the mode of PDGFB-mediated activation of mTORC1 signalling pathway in clear cell renal cell carcinoma , Ketua Projek , 01-07-2020 sehingga 30-06-2022 , Universiti
Identifying Genomic Copy Number Variants That Are Associated with Obesity And Its Related Phenotype Among Malaysian Undergraduate Students in Klang Valley. , Penyelidik Bersama , 01-11-2020 sehingga 31-10-2022 , Kebangsaan
Optical sensor technique based on high Quality factor suspended 1D photonic crystal (PhC) structures for creatinine detection using non-invasive approach. , Penyelidik Bersama , 01-11-2020 sehingga 31-10-2022 , Kebangsaan
Elucidating the mechanism of secretion for human pro-metastatic AGR2 protein , Penyelidik Bersama , 14-12-2018 sehingga 13-12-2021 , Universiti
Identification of Metasmai in Serous Ovarian Cancer , Penyelidik Bersama , 01-04-2014 sehingga 31-03-2015 , Universiti
CHARACTERISATION OF MOLECULAR POTRAITS OF HUMAN SEROUS OVARIAN CANCER , Penyelidik Bersama , 01-01-2013 sehingga 31-03-2014 , Universiti
CHARACTERISATION OF MOLECULAR ARCHITECTURE OF HUMAN SEROUS OVARIAN CANCER , Penyelidik Bersama , 01-01-2013 sehingga 31-03-2014 , Universiti
MOLECULAR CHARACTERISATION OF RECURRENT ENDOMETRIAL CANCER , Penyelidik Bersama , 01-01-2013 sehingga 31-03-2014 , Universiti
The Role of STAT1-Targeting miRNA in Endometrial Cancer , Penyelidik Bersama , 01-03-2011 sehingga 28-02-2013 , Universiti
ANUGERAH DAN PENGURUSAN / AWARD AND STEWARDSHIP
(Nama Anugerah/Pentadbiran),(Institusi Penganugerahan),(Tahun)

Anugerah UKM

Anugerah Perkhidmatan Cemerlang / Anugerah Perkhidmatan Cemerlang , 2022
PENYELIAAN PELAJAR / SUPERVISION

Pelajar Sarjana

NISA SYAKILA BINTI A RAHMAN, Sarjana
NUR HIDAYAH BINTI LONG, Sarjana
Menjelaskan perubahan metilasi endometrium hoxa 10 dalam kesuburan wanita endometriosis setelah dimodulasi oleh hormon pelepas gonadotropin, NURUNNAJAH BINTI LAZIM, Sarjana
Menyiasat gen GREM1 pada kumulus sel dan hubungannya dengan HOMA-IR di kalangan wanita dengan Sindrom Ovarium Polikistik (PCOS), NURAINIE BINTI SAYUTTI, Sarjana

Pelajar Doktor Falsafah

ANALISIS BERSEPADU EPIGENOMIK DAN TRANSKRIPTOMIK DALAM KANSER KOLOREKTAL MELALUI PENDEKATAN EPIGENOM MENYELURUH, RASHIDAH BINTI C BAHARUDIN, Doktor Falsafah
Developing A Pharmacogenomic Model In Wharton's Jelly Cells-Derived Neurospheres Using Crispr Gene-Editing System To Understand Caffeine Sensitivity In The Developing Brain, WONG POH KUAN, Doktor Falsafah
NURUL NADIA BINTI MOHAMAD ZAMBERI, Doktor Falsafah
SYAZALINA BINTI ZAHARI, Doktor Falsafah
KHIDMAT SOSIAL / SOCIAL @ PUBLIC ENGAGEMENT
(Sumbangan),(Tempoh),(Peringkat)

Khidmat Luar

Construction of a microRNA-mRNA network combining transcription factors in decidualized endometriotic cyst stromal cells using bioinformatics analysis , 02-06-2020 sehingga 22-07-2020 , Antarabangsa
Nisa Syakila Binti A Rahman , 09-03-2020 sehingga 09-03-2020 , Antarabangsa
ASMAA Y. I. ABUHAMAD , 10-06-2020 sehingga 10-06-2020 , Kebangsaan
A Review on the potential of CRISPR/Cas9 technology in knocking-out CYP3A4 and CYP2D6 genes from the THLE-2 cell lines , 27-11-2020 sehingga 15-12-0320 , Kebangsaan
Ling Sheen , 10-11-2020 sehingga 19-11-2020 , Antarabangsa
Cell cycle arrest and apoptosis induction of enzymatic prepared low molecular citrus pectin (LCP) on Liver Cancer HepG2 Cells , 23-12-2020 sehingga 07-01-0321 , Antarabangsa
Post-Translational Modifications: Host DefencenMechanism, Pathogenic Weapon, and Emerged Target of Anti-Infective Drugs , 29-12-2020 sehingga 19-01-0321 , Antarabangsa
QIAGEN dPCR Learn & Earn Series - Fund Your Science - Research Grant , 10-12-2020 sehingga 01-01-1970 , Kebangsaan
General CRISPR experimental workflow and case studies , 28-01-2021 sehingga 28-01-0321 , Antarabangsa
HERBAL MEDICINE IN FIGHTING AGAINST COVID 19 NEW BATTLE WITH AN OLD WEAPON , 18-01-2021 sehingga 19-01-0321 , Antarabangsa
The AppliThe Application of Peptide in Glioma: a Novel Tool for Therapycation of Peptide in Glioma: a Novel Tool for Therapy , 15-02-2021 sehingga 28-02-0321 , Antarabangsa
Evaluating the effect of RUNX1/ETO expression on mutagenesis at the NPM1 locus using flow cytometry , 16-02-2021 sehingga 05-03-0321 , Kebangsaan
SCIENTIFIC COMMITTEE OF THE INTERNATIONAL CONFERENCE ON DRUG DISCOVERY AND TRANSLATIONAL MEDICINE 2021. , 04-06-2021 sehingga 07-09-2021 , Antarabangsa
Ling Sheen , 12-04-2021 sehingga 12-04-2021 , Antarabangsa
The Roles of Tumour Suppressor miRNAs in Liver Cancer Cell , 05-07-2021 sehingga 19-07-2021 , Antarabangsa
Lembaga Teknologis Malaysia , 26-08-2021 sehingga 19-01-0321 , Kebangsaan
Histone methyltransferase KMT2D aggravates development of oral squamous cell carcinoma via sustaining Wnt Bcatenin signaling , 07-12-2021 sehingga 20-12-2021 , Antarabangsa
ICDDTM 21 Pre Conference Workshop CRISPR Cas9 Gene Editing , 07-12-2021 sehingga 07-12-2021 , Antarabangsa
PENSYARAH TAMU UNTUK PROGRAM PENGAJARAN KOLABORATIF KOD KURSUS BIO411 SEL BIOLOGI DAN BMS413 SEL DAN KEHIDUPAN , 07-01-2022 sehingga 19-01-0321 , Kebangsaan
Nisa Syakila Abd Rahman , 21-01-2022 sehingga 23-01-2022 , Antarabangsa
Delta like 2 Homologue Acts as a Novel Prognostic Biomarker for Clear Cell Renal Cell Carcinoma Based on Multiple Gene Expression Databases , 02-02-2022 sehingga 19-01-0321 , Antarabangsa
Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer A promising rising star , 25-02-2022 sehingga 19-01-0321 , Antarabangsa
Histone methyltransferase KMT2D cooperates with MEF2A to promote the stem-like properties of oral squamous cell carcinoma , 25-03-2022 sehingga 01-01-9321 , Antarabangsa
Cancer Biomarkers Detection: Methods And Applications , 21-04-2022 sehingga 18-08-2022 , Antarabangsa
Use of iTRAQ-based quantitative proteomic identification of Chromogranin-A and Ubiquitin carboxyl-terminal hydrolase isozyme L1 correlated with lymph node metastasis in colorectal carcinoma , 12-05-2022 sehingga 19-01-0321 , Antarabangsa
Synergic effect of metformin and everolimus on mitochondrial dynamics of renal cell carcinoma , 11-06-2022 sehingga 21-06-2022 , Antarabangsa
PROGRAM PENGAJARAN KOLABORATIF KOD KURSUS BIO411 SEL BIOLOGI DAN BIO631 TOPIK KHAS BIOLOGI , 24-06-2022 sehingga 24-06-2022 , Kebangsaan
Hands-On CRISPR Cas9 Gene Editing Workshop , 27-06-2022 sehingga 30-06-2022 , Kebangsaan
Lembaga Teknologis Malaysia (MBOT) , 28-06-2022 sehingga 28-03-2023 , Kebangsaan
Application of the CRISPR/Cas9-gene-editing system and its participation in modern science , 15-08-2022 sehingga 05-09-2022 , Antarabangsa
Penyeliaan Pelajar Sarjana Mod Penyelidikan (Master Of Science) , 14-02-2022 sehingga 13-02-2024 , Kebangsaan
Penyeliaan Pelajar Sarjana Mod Penyelidikan (Master Of Science) , 03-12-2020 sehingga 02-12-2022 , Kebangsaan
Penyeliaan Pelajar Internship , 28-09-2020 sehingga 09-03-2021 , Antarabangsa
Penyeliaan Pelajar Sarjana Mix Mode (Master Of Science) , 09-07-2020 sehingga 08-07-2022 , Kebangsaan
Penyeliaan Pelajar Sarjana Mod Penyelidikan (Master Of Science) , 16-07-2020 sehingga 15-07-2022 , Kebangsaan
Penyeliaan Pelajar Sangkutan di UMBI , 03-08-2020 sehingga 02-11-2020 , Kebangsaan
CRISPR-Cas9 Genome Technology Webinar , 13-08-2022 sehingga 13-08-2022 , Antarabangsa
High level of shank-associated RH domain interacting protein in tumor promotes ovarian cancer progression , 11-11-2022 sehingga 25-11-2022 , Antarabangsa
Nisa Syakila Abdul Rahman , 14-11-2022 sehingga 18-11-2022 , Kebangsaan
Nisa Syakila Abdul Rahman , 14-11-2022 sehingga 18-11-2022 , Kebangsaan

Khidmat Dalam

JAWATANKUASA CRISPR GENOME EDITING WORKSHOP 2022 , 18-10-2022 sehingga 20-10-2022 , Fakulti / Institut / Pusat Perkhidmatan
JAWATANKUASA PASUKAN PEMIKIR KHAS (THINK TANK) TINDAKAN SELEPAS COVID , 19-11-2020 sehingga 18-11-2021 , Fakulti / Institut / Pusat Perkhidmatan
JAWATANKUASA UTAMA MAJLIS ANUGERAH KECEMERLANGAN UMBI , 01-06-2021 sehingga 31-12-2021 , Fakulti / Institut / Pusat Perkhidmatan
JUALAN GERAI KUIH RAYA UMBI , 11-04-2022 sehingga 29-04-2022 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Bengkel Semakan Kurikulum Program Siswazah UMBI , 16-07-2021 sehingga 31-12-2021 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Penerbitan, Website & Jurnal UMBI , 01-01-2019 sehingga 31-12-2021 , Fakulti / Institut / Pusat Perkhidmatan
Pasukan Khas Ujian Saringan Covid-19 , 26-03-2020 sehingga 05-06-2020 , Universiti