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Curriculum Vitae


MAKLUMAT ASAS

DR. RYIA ILLANI BINTI MOHD YUNOS

PEGAWAI SAINS
INSTITUT BIOLOGI MOLEKUL PERUBATAN UKM (UMBI)
ryiaillani@ukm.edu.my
No.rasmi UKM : 03 8921 5555
BIOGRAFI /BIOGRAPHY


Dr. Ryia Illani Mohd Yunos is a Senior Science Officer at UKM Medical Molecular Biology UKM (UMBI) and has served UKM for more than 10 years. She holds PhD in Molecular Medicine from Universiti Kebangsaan Malaysia. She previously earned her Master’s in Molecular medicine and BSc in Genetics, both from Universiti Kebangsaan Malaysia. Her PhD project focuses on the characterization of somatic alterations in colorectal cancer patients via a whole-genome sequencing approach. Dr. Ryia research interest revolves around understanding cancer genetics and precision medicine in cancers. She has been trained in the field of molecular biology for more than a decade and involved in research utilizing various state-of-the-art laboratory techniques throughout her cancer research works specifically in colorectal cancers and pediatric cancers. She is well trained in next generation sequencing of short and long read approach particularly in whole genome, whole exome as well as targeted DNA sequencing. She is developing an interest in bioinformatics and variant analysis for precision medicine. She is also a team member of the national COVID19 genome surveillance team. Her expertise in cancer research has been recognized with numerous awards at national and international conferences, including Young Investigator Award, Best Paper Award and Best Poster Award. Several of her research works have been published in high impact journals such as Biomolecule, Frontiers in Molecular Biosciences and International Journal of Infectious Diseases.

KELAYAKAN AKADEMIK / ACADEMIC QUALIFICATION
(Bidang Pengajian),(Peringkat),(Institusi),(Tahun)
Biologi Molekul , Sarjana , UKM , 2012
Genetik , Sarjana Muda dengan Kepujian , UKM , 2007
KEPAKARAN / EXPERTISE
CLINICAL AND HEALTH SCIENCES - CLINICAL MEDICAL (Cancer Genomics, Cancer Biomarkers, Precision Medicine)
PURE AND APPLIED SCIENCES - BIOLOGY (Whole Genome Sequencing, Whole Exome Sequencing, Targeted DNA Sequencing, qPCR, Cloning, Western blot, Cell culture, Cell Based Assay, Bioinfomatics)
PENERBITAN TERKINI / LATEST PUBLICATION

Penerbitan Berimpak Tinggi

Ryia Illani My, Nurul-syakima Am, Jia-shiun K, Sazuita S, Muhiddin I, Saiful Effendi S, Francis Yew Ft, Najwa Farhah My, Mohd Ridhwan Ar, Norshahidah Mn, Nadiah A, Isa Md Rose, Ismail Sagap, Luqman Mazlan, Rahman Jamal.  (2023).  Whole Genome Sequencing Of Malaysian Colorectal Cancer Patients Reveals Specific Druggable Somatic Mutations.  - Frontiers In Molecular Biosciences.  1-20. 
Mohd Amin Azuwar, Nor Azlan Nor Muhammad, Nor Afiqah-aleng, Nurul-syakima Ab Mutalib, Najwa Farhah Md. Yusof, Ryia Illani Mohd Yunos, Muhiddin Ishak, Sazuita Saidin, Isa Mohamed Rose, Ismail Sagap, Luqman Mazlan, Zairul Azwan Mohd Azman, Musalmah Mazlan.  (2022).  Tcga-my: A Systematic Repository For Systems Biology Of Malaysian Colorectal Cancer.  - Life.  1-14. 
Nor Azila Muhammad Azami...nurul Syakima Ab Mutalib...zahirrah Begam Mohamed Rasheed...muhiddin Ishak, Ryia Illani Mohd Yunos...mira Farzana Mohamad Mokhtar, Nur Alyaa Afifah Md Shahri, Khairun Ghafar, Siti Nur Hasanah Mohd Yusuf...rahman Jamal....  (2022).  Sars-cov-2 Genomic Surveillance In Malaysia: Displacement Of B.1.617.2 With Ay Lineages As The Dominant Delta Variants And The Introduction Of Omicron During The Fourth Epidemic Wave.  - International Journal Of Infectious Diseases.  216-226. 
Ryia Illani Mohd Yunos, Nurul Syakima Ab Mutalib, Francis Yew Fu Tieng, Nadiah Abu, Rahman Jamal.  (2020).  Actionable Potentials Of Less Frequently Mutated Genes In Colorectal Cancer And Their Roles In Precision Medicine.  - Biomolecules.  1-20. 
Francis Tieng Yew Fu, Rashidah Baharudin, Nadiah Abu, Ryia Illani Mohd Yunos, Learn-han Lee, Nurul Syakima Ab Mutalib.  (2020).  Single Cell Transcriptome In Colorectal Cancer - Current Updates On Its Application In Metastasis, Chemoresistance And The Roles Of Circulating Tumor Cells.  - Frontiers In Pharmacology.  1-8. 
Nurul-syakima Ab Mutalib, Ryia Illani Mohd Yunos, Najwa Farhah Mohd Yusof, Muhiddin Ishak, Sazuita Saidin, Isa Mohamed Rose, Luqman Mazlan, Ismail Sagap, Rahman Jamal.  (2019).  The Landscape Of Recurrent Noncoding Mutations In Colorectal Cancers.  - Gut.  A36. 
Nurul-syakima Ab Mutalib, Saiful Effendi Syafruddin, Reena Rahayu Md Zain, Ahmad Zailani Hatta Mohd Dali, Ryia Illani Mohd Yunos, Sazuita Saidin, Rahman Jamal And Norfilza M Mokhtar.  (2014).  Molecular Characterization Of Serous Ovarian Carcinoma Using A Multigene Next Generation Sequencing Cancer Panel Approach.  - Bmc Research Notes.  1-10. 

Penerbitan WOS

Shafiee M.n., Malik D.a., Yunos R.i.m., Atiomo W., Omar M.h., Ghani N.a.a., Hatta A.z., Seedhouse C., Chapman C., Mokhtar N.m..  (2015).  The Effect Of Metformin On Endometrial Tumor-regulatory Genes And Systemic Metabolic Parameters In Polycystic Ovarian Syndrome-a Proof-of-concept Study.  - Gynecological Endocrinology.  286-290. 
Mohamad Nasir Shafiee, Dahlia Abd Malik, Ryia Illani Mohd Yunos, William Atiomo, Mohd Hashim Omar, Nor Azurah Abdul Ghani, Ahmad Zailani Hatta, Claire Seedhouse, Caroline Chapman, Norfilza Mohd Mokhta.  (2014).  The Effect Of Metformin On Endometrial Tumor-regulatory Genes And Systemic Metabolic Parameters In Polycystic Ovarian Syndrome - A Proof-of-concept Study.  - Gynecological Endocrinology.  1-5. 

Penerbitan SCOPUS/ERA

Ryia Illani My, Nurul-syakima Am, Jia-shiun K, Sazuita S, Muhiddin I, Saiful Effendi S, Francis Yew Ft, Najwa Farhah My, Mohd Ridhwan Ar, Norshahidah Mn, Nadiah A, Isa Md Rose, Ismail Sagap, Luqman Mazlan, Rahman Jamal.  (2023).  Whole Genome Sequencing Of Malaysian Colorectal Cancer Patients Reveals Specific Druggable Somatic Mutations.  - Frontiers In Molecular Biosciences.  1-20. 
Mohd Amin Azuwar, Nor Azlan Nor Muhammad, Nor Afiqah-aleng, Nurul-syakima Ab Mutalib, Najwa Farhah Md. Yusof, Ryia Illani Mohd Yunos, Muhiddin Ishak, Sazuita Saidin, Isa Mohamed Rose, Ismail Sagap, Luqman Mazlan, Zairul Azwan Mohd Azman, Musalmah Mazlan.  (2022).  Tcga-my: A Systematic Repository For Systems Biology Of Malaysian Colorectal Cancer.  - Life.  1-14. 
Nor Azila Muhammad Azami...nurul Syakima Ab Mutalib...zahirrah Begam Mohamed Rasheed...muhiddin Ishak, Ryia Illani Mohd Yunos...mira Farzana Mohamad Mokhtar, Nur Alyaa Afifah Md Shahri, Khairun Ghafar, Siti Nur Hasanah Mohd Yusuf...rahman Jamal....  (2022).  Sars-cov-2 Genomic Surveillance In Malaysia: Displacement Of B.1.617.2 With Ay Lineages As The Dominant Delta Variants And The Introduction Of Omicron During The Fourth Epidemic Wave.  - International Journal Of Infectious Diseases.  216-226. 
Francis Tieng Yew Fu, Rashidah Baharudin, Nadiah Abu, Ryia Illani Mohd Yunos, Learn-han Lee, Nurul Syakima Ab Mutalib.  (2020).  Single Cell Transcriptome In Colorectal Cancer - Current Updates On Its Application In Metastasis, Chemoresistance And The Roles Of Circulating Tumor Cells.  - Frontiers In Pharmacology.  1-8. 
Ryia Illani Mohd Yunos, Nurul Syakima Ab Mutalib, Francis Yew Fu Tieng, Nadiah Abu, Rahman Jamal.  (2020).  Actionable Potentials Of Less Frequently Mutated Genes In Colorectal Cancer And Their Roles In Precision Medicine.  - Biomolecules.  1-20. 
Nurul-syakima Ab Mutalib, Ryia Illani Mohd Yunos, Najwa Farhah Mohd Yusof, Muhiddin Ishak, Sazuita Saidin, Isa Mohamed Rose, Luqman Mazlan, Ismail Sagap, Rahman Jamal.  (2019).  The Landscape Of Recurrent Noncoding Mutations In Colorectal Cancers.  - Gut.  A36. 
Shafiee M.n., Malik D.a., Yunos R.i.m., Atiomo W., Omar M.h., Ghani N.a.a., Hatta A.z., Seedhouse C., Chapman C., Mokhtar N.m..  (2015).  The Effect Of Metformin On Endometrial Tumor-regulatory Genes And Systemic Metabolic Parameters In Polycystic Ovarian Syndrome-a Proof-of-concept Study.  - Gynecological Endocrinology.  286-290. 
Mohamad Nasir Shafiee, Dahlia Abd Malik, Ryia Illani Mohd Yunos, William Atiomo, Mohd Hashim Omar, Nor Azurah Abdul Ghani, Ahmad Zailani Hatta, Claire Seedhouse, Caroline Chapman, Norfilza Mohd Mokhta.  (2014).  The Effect Of Metformin On Endometrial Tumor-regulatory Genes And Systemic Metabolic Parameters In Polycystic Ovarian Syndrome - A Proof-of-concept Study.  - Gynecological Endocrinology.  1-5. 
Nurul-syakima Ab Mutalib, Saiful Effendi Syafruddin, Reena Rahayu Md Zain, Ahmad Zailani Hatta Mohd Dali, Ryia Illani Mohd Yunos, Sazuita Saidin, Rahman Jamal And Norfilza M Mokhtar.  (2014).  Molecular Characterization Of Serous Ovarian Carcinoma Using A Multigene Next Generation Sequencing Cancer Panel Approach.  - Bmc Research Notes.  1-10. 

Penerbitan Lain-lain

Mohamad Aimanuddin Mohtar, Ryia Illani Mohd Yunos, Nor Azian Abdul Murad.  (2022).  Laboratory Manual For Biosafety & Biosecurity In Umbi.  - 1-21. 
Siti Nur Hasanah Mohd Yusuf, Ryia Illani Mohd Yunos.  (2022).  Lawatan Dan Sesi Hands On Teknik Asas Biologi Molekul Dari Syarikat Pantas Niaga Ke Makmal Umbi.  - 1-3. 
Ryia Illani Mohd Yunos, Syahidatun Najwa Abu Zahid.  (2022).  Perubatan Jitu: Masa Depan Rawatan Kanser.  - Majalah Sains.  1. 
Syahidatun Najwa Abu Zahid, Ryia Illani Mohd Yunos.  (2022).  Fahami Kaunseling Genetik Dan Kepentingannya.  - Majalah Sains.  1-7. 
Nadiah Abu, Shivapriya Jeyaraman, Sazuita Saidin, Ryia Illani Mohd Yunos, Muaatamarulain Mustangin, Azyani Yahaya, Nik Muhd Aslan Abdullah, Nurul Syakima Ab Mutalib, Rahman Jamal.  (2020).  Circanapc7 Regulates Chemoresistant Colorectal Cancer Via The Mir338 Krt23 Axis.  - Ksmo 2020 Virtual: 13th Annual Meeting & 2020 International Conference The Korean Society Of Medical Oncology, 8th International Faco Conference.  1-10. 
Professor Datuk Dr. A. Rahman A. Jamal, Dr. Nurul Syakima Ab. Mutalib, Ryia Illani Mohd Yunos.  (2020).  Uncovering The Molecular Landscape Of 50 Malaysian Colorectal Cancer Genomes.  - Website Umbi.  1-2. 
Ryia Illani Mohd Yunos, Nurul-syakima Ab Mutalib, Jia-shiun Khoo , Sazuita Saidin, Muhiddin Ishak, Najwa Farhah Md Yusof, Norshahidah Mahamad Nadzir, Isa Md. Rose, Ismail Sagap, Luqman Mazlan, Nadiah Abu, Rahman Jamal.  (2019).  Identification Of Structural Variants In Malaysian Colorectal Cancer Genome.  - 27th Faobmb And 44th Msbmb Conference.  133. 
Shivapriya Jeyaraman, Sazuita Saidin, Ryia Illani Mohd Yunos, Muaatamarulain Mustangin, Azyani Yahaya , Nurul Syakima Ab Mutalib , Ezanee Azlina Mohamad Hanif , Rahman Jamal , Nadiah Abu.  (2019).  In Depth Functional Analysis Of Circular Rnas In Regulating Chemoresistance In Folfox Resistant Colon Cancer Cells.  - 1st Malaysian Association For Cancer Research Scientific Conference.  32. 
Ryia Illani Mohd Yunos, Nurul-syakima Ab Mutalib, Jia-shiun Khoo, Sazuita Saidin, Muhiddin Ishak, Nadiah Abu, Najwa F. Mohd Yusof, Norshahidah Mahamad Nazir, Isa M. Rose, Ismail Sagap, Luqman Mazlan And Rahman Jamal.  (2019).  Uncovering The Landscape Of Somatic Mutations In Malaysian Colorectal Cancer Patients Via Whole Genome Sequencing.  - International Conference On Drug Discovery And Translational Medicine 2018.  1. 
Ryia-illani Mohd Yunos1, Nurul-syakima Ab Mutalib1, Janice Khor Sheau Sean2, Sazuita Saidin1, Mohd Ridhwan Abd. Razak1, Norshahidah Mahamad Nadzir1, Zuraini Abd Razak1, Isa Md. Rose3, Ismail Sagap4, Luqman Mazlan4, Rahman Jamal1.  (2018).  Characterisation Of Genomic Alterations In Proximal And Distal Colorectal Cancer Patients.  - International Digestive Disease Forum 2018. 
Ryia-illani Mohd Yunos1, Nurul-syakima Ab Mutalib1, Luqman Mazlan2, Rahman Jamal1.  (2018).  Development Of A Semiconductor Sequencing-based Panel For Screening Individuals With Lynch Syndrome.  - Coloproctology 2018. 
Nurul Syakima Binti Ab Mutalib;a. Rahman Bin A. Jamal;norfilza Binti Mohd Mokhtar;sazuita Binti Saidin;ryia Illani Binti Mohd Yunos.  (2018).  Genome-wide Identification Of Mir-200c Functional Targets In Metastatic Ovarian Cancer.  -
Ryia-illani Mohd Yunos, Nurul-syakima Ab Mutalib, Janice Khor Sheau Sean , Sazuita Saidin, Mohd Ridhwan Abd Razak, Isa Md. Rose, Ismail Sagap, Luqman Mazlan,rahman Jamal.  (2017).  Development Of A Semiconductor Sequencing-based Panel For Screening Individuals With Lynch Syndrome.  - International Conference In Medicine 2017 (icim 2017). 
Ryia Illani Mohd Yunos,nurul Syakima Ab Mutalib,nadiah Abu,jiashiun Khoo,sazuita Saidin,muhiddin Ishak,najwa Farhah Md Yusof,norshahidah Mahamad Nadzir,isa Md. Rose,ismail Sagap,lukman Mazlan,rahman Jamal.  (2017).  The Landscape Of Somatic Mutations In Malaysian Colorectal Cancer Patients Using Whole Genome Sequencing.  - 7th Regional Conference On Molecular Medicine (rcmm) In Conjunction With 3rd National Conference For Cancer Research 2017. 
Ryia Illani Mohd Yunos, Nor Azurah Abd Ghani, Dahlia Abd Malik, Nurul Syakima Ab Mutalib, Norfilza Mohd Mokhtar.  (2013).  Transcript Profiles Of Endometrial Cancer Related Gene In Pre- And Post- Metformin Treatment In Polycystic Ovarian Syndrome.  - 1st National Conference For Cancer Research & 5th Regional Conference On Molecular Medicine. 
PROJEK PENYELIDIKAN / RESEARCH PROJECT
(Tajuk),(Peranan),(Tempoh),(Tahap)

Aktif

SARS-CoV-2 Genomics Surveillance , Penyelidik Bersama , 13-01-2022 sehingga 31-12-2024 , Kebangsaan
Initiative For Precision Medicine In Pediatric Cancer Therapy (IMPACT): Improving Paediatric Cancer Survival Rate , Penyelidik Bersama , 20-10-2021 sehingga 31-12-2024 , Kebangsaan
A Covid-19 patients` cohort: Genetic variants and host risk factors associated with severity of infection (COV-GEN Study) , Penyelidik Bersama , 01-07-2021 sehingga 30-06-2024 , Kebangsaan

Tamat

Immunogenomics Analysis of Colorectal Cancer: Identification and validation of neoantigens via TCR-engineered T cells , Penyelidik Bersama , 01-09-2019 sehingga 30-09-2023 , Kebangsaan
Development of Method in Screening Individual With Lynch Syndrome , Penyelidik Bersama , 15-06-2015 sehingga 30-09-2016 , Universiti
Genome-Wide Identification Of Mir-200c Functional Targets In Metastatic Ovarian Cancer , Penyelidik Bersama , 01-12-2013 sehingga 31-05-2016 , Universiti
ANUGERAH DAN PENGURUSAN / AWARD AND STEWARDSHIP
(Nama Anugerah/Pentadbiran),(Institusi Penganugerahan),(Tahun)

Anugerah UKM

Anugerah Perkhidmatan Cemerlang / Anugerah Perkhidmatan Cemerlang , 2015
Anugerah Perkhidmatan Cemerlang / Anugerah Perkhidmatan Cemerlang , 2022
KHIDMAT SOSIAL / SOCIAL @ PUBLIC ENGAGEMENT
(Sumbangan),(Tempoh),(Peringkat)

Khidmat Dalam

JAWATANKUASA SEBUTHARGA UNTUK MEMBEKAL PERKHIDMATAN PENYELENGGARAAN DAN JAMINAN SECARA KOMPREHENSIF BAGI PERALATAN MESIN PENJUJUKAN GENOM (MISEQ ILLUMINA) BAGI TEMPOH SATU (1) TAHUN KEPADA INSTITUT BIOLOGI MOLEKUL PERUBATAN UKM (UMBI) , 02-01-2023 sehingga 31-12-2023 , Fakulti / Institut / Pusat Perkhidmatan
JAWATANKUASA MAJLIS MAKAN MALAM UMBI , 02-01-2023 sehingga 31-12-2023 , Fakulti / Institut / Pusat Perkhidmatan
JAWATANKUASA PENYEDIAAN DAN PENILAIAN SEBUTHARGA UNTUK MEMBEKAL DAN MENGHANTAR REAGEN BAGI LIBRARY PREPARATION & UJIAN PENJUJUKAN DNA KESELURUHAN COVID-19 MENGGUNAKAN PLATFORM ILLUMINA MISEQ SYSTEM SECARA BERPERINGKAT BAGI TEMPOH SATU (1) TAHUN , 18-04-2023 sehingga 18-04-2024 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Bengkel Pemurnian Perancangan Strategik UMBI 2022 , 20-01-2022 sehingga 20-01-2022 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Hari DNA & Hari Terbuka UMBI , 04-01-2023 sehingga 31-12-2023 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Keselamatan, Kesihatan dan Pekerjaan (JKKP) , 01-01-2020 sehingga 31-12-2021 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Penyedia/Penilaian Spesifikasi Teknikal bagi Sebutharga - PENJUJUKAN DNA MENGGUNAKAN PANEL KANSER KANAK-KANAK (PROSES LIBRARY PREPARATION DAN TARGETED SEQUENCING) BERSAMA MESIN UJIAN (SEWAAN BERSAMA REAGEN) SECARA BERPERINGKAT UNTUK TEMPOH DU , 28-06-2022 sehingga 28-06-2024 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Penyedia/Penilaian Spesifikasi Teknikal bagi Sebutharga - Proses Library Preparation & Whole Genome Sequencing : Covid-19 Genome bersama Mesin Ujian tempoh 1 tahun , 29-06-2022 sehingga 31-12-2022 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Penyedia/Penilaian Spesifikasi Teknikal bagi Sebutharga - Proses Library Preparation for Whole Genome Sequencing (Covid-19 Genome Surviellance) , 26-09-2021 sehingga 25-09-2022 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Penyedia/Penilaian Spesifikasi Teknikal bagi Sebutharga - Proses Library preparation & Whole Genome menggunakan Platform MiSeq secara berperingkat bagi tempoh 1 tahun , 18-04-2022 sehingga 31-12-2022 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Penyedia/Penilaian Spesifikasi Teknikal bagi Sebutharga - Reagen Novel Coronavirus Detection Test kits using RT-PCR dalam tempoh 1 tahun , 09-03-2022 sehingga 08-03-2023 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Penyedia/Penilaian Spesifikasi Teknikal bagi Sebutharga - Reagen Pengekstrakan Viral RNA secara automatik bersama mesin ujian dalam tempoh 1 tahun , 09-03-2022 sehingga 08-03-2023 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Penyedia/Penilaian Spesifikasi Teknikal bagi Sebutharga - SARS-COV-2 Genomic Survillence secara Ujian Penjujukan DNA (Projek MOSTI-UKM/IMR) , 06-10-2021 sehingga 05-10-2022 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Real Time PCR Gene Expression Analysis , 13-12-2022 sehingga 14-12-2022 , Fakulti / Institut / Pusat Perkhidmatan
Jawatankuasa Real Time PCR Gene Expression Analysis Workshop , 15-06-2022 sehingga 16-06-2022 , Fakulti / Institut / Pusat Perkhidmatan
Lantikan Pegawai Risiko PTj 2021 , 01-01-2021 sehingga 31-12-2021 , Fakulti / Institut / Pusat Perkhidmatan
MAJLIS APRESIASI DAN PENGANUGERAHAN UMBI , 30-01-2015 sehingga 30-01-2015 , Fakulti / Institut / Pusat Perkhidmatan
Pasukan Khas Petugas Covid-19 2021 , 01-01-2021 sehingga 31-12-2021 , Fakulti / Institut / Pusat Perkhidmatan
Pasukan Khas Ujian Saringan Covid-19 , 26-03-2020 sehingga 05-06-2020 , Universiti
Sambutan Hari DNA 2015 UMBI , 23-04-2015 sehingga 23-04-2015 , Fakulti / Institut / Pusat Perkhidmatan