Biografi/ Biography :
Suzana binti Makpol is a Professor of Biochemistry at Faculty of Medicine, Universiti Kebangsaan Malaysia. She graduated from Universiti Kebangsaan Malaysia with Bachelor of Science Hons (Clinical Biochemistry) in 1992 and obtained her PhD (Medical Biochemistry) from the same university in 1997. She then went to Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan in year 2000 for research training and did an attachment at Linus Pauling Institute, Oregon State University, USA in 2008. Professor Makpol has been investigating the molecular changes that occur with ageing and elucidating the molecular mechanisms of natural compounds such as palm tocotrienols, microalgae Chlorella vulgaris, gelam honey, Piper betle and Zingiber officinale Roscoe (ginger) in delaying ageing with emphasis on intracellular signaling pathways and its regulation by genes, transcription factors and micro RNAs. In her studies, she has been using stress-induced premature senescence (SIPS) model of human diploid fibroblasts, replicative senescence model of human diploid fibroblasts, and myoblasts which represent cellular ageing besides the animal model. She has also developed the in vitro model of Alzheimer’s disease carrying the double Swedish/Indiana mutations. She has published more than 100 papers in peer-reviewed international journals and presented more than 150 seminar papers in local and international conferences. She has held many research grants and is currently involved in several research projects.
nuraqila mohd murshid, nur fatin nabilah mohd sahardi and suzana makpol. (2025). advancing alzheimer’s disease modelling by developing a refined biomimetic brain microenvironment for facilitating high-throughput screening of pharmacological treatment strategies. - international journal of molecular sciences. 1 - 21.
anika tabassum, siti liyana saud gany, jen kit tan, suzana makpol. (2025). untargeted liver metabolites profiling and oxidative stress and inflammatory markers expression in sprague dawley rats supplemented with palm tocotrienol-rich fraction and its effect on hepatic changes during ageing. - 5th international conference on advances in medical science 2025. .
rabiatul adawiyah razali, wan zurinah wan ngah, suzana makpol, daijiro yanagisawa, tomoko kato and ikuo tooyama. (2025). shifting perspectives on the role of tocotrienol vs. tocopherol in brain health: a scoping review. - international journal of molecular sciences. 1 - 58.
a. atikah, m. suzana, w.a.h. wan haslina, norshamsiah, m. mushawiahti, k.s.s. birinder, s.f. tang, m.l.c. bastion. (2025). randomised controlled trial on effects of topical insulin compared to artificial tears and normal saline on tear inflammatory mediator levels and clinical parameters in diabetics with dry eye disease. - contact lens & anterior eye. 1 - 8.
nurul tihani kamarulzaman, suzana makpol. (2025). the link between mitochondria and sarcopenia. - journal of physiology and biochemistry. 1 - 20.
nurul tihani kamarulzaman, suzana makpol. (2025). the link between mitochondria and sarcopenia. - journal of physiology and biochemistry. 1 - 20.
nuraqila mohd murshid, nur fatin nabilah mohd sahardi and suzana makpol. (2025). advancing alzheimer’s disease modelling by developing a refined biomimetic brain microenvironment for facilitating high-throughput screening of pharmacological treatment strategies. - international journal of molecular sciences. 1 - 21.
rabiatul adawiyah razali, wan zurinah wan ngah, suzana makpol, daijiro yanagisawa, tomoko kato and ikuo tooyama. (2025). shifting perspectives on the role of tocotrienol vs. tocopherol in brain health: a scoping review. - international journal of molecular sciences. 1 - 58.
a. atikah, m. suzana, w.a.h. wan haslina, norshamsiah, m. mushawiahti, k.s.s. birinder, s.f. tang, m.l.c. bastion. (2025). randomised controlled trial on effects of topical insulin compared to artificial tears and normal saline on tear inflammatory mediator levels and clinical parameters in diabetics with dry eye disease. - contact lens & anterior eye. 1 - 8.
maryam fatimah abu bakar, siok fong chin, suzana makpol, jen kit tan, azmawati mohammed nawi. (2024). diagnostic performance of serum metabolites biomarker associated with colorectal adenoma: a systematic review. - peerj. 1 - 14.
amnani aminuddin, pei yuen ng, chee onn leong, suzana makpol, eng wee chua. (2024). potential role of heteroplasmic mitochondrial dna mutations in modulating the subtype-specific adaptation of oral squamous cell carcinoma to cisplatin therapy. - discover oncology. 1 - 17.
khaizurin tajul arifin, noor ikhwan shansuddin, norwahidah abdul karim & suzana makpol. (2022). hot water extract from saccharomyces cerevisiae scavenges dpph and reduces senescence associated b-galactosidase (sa-b-gal) in human dermal fibroblasts. - sains malaysiana. 2415-2424.
sheng zhang lim, raja affendi raja adli, suzana makpol & eng wee chua. (2022). therapeutic monitoring of thiopurine metabolites: validation of an hplc method and preliminary findings from a small cohort of malaysian patients with inflammatory bowel disease. - sains malaysiana. 1847-1859.
zaizuhana shahrim; suzana makpol; geok chin tan; nurul aishah muhammad and zafarizal aldrin azizul hasan. (2022). topical application of the palm tocotrienol-rich fraction (trf) enhances cutaneous wound healing in type 2 diabetic mice. - journal of oil palm research. 546-561.
jen kit tan, sakinah husna abdul razak, nazirah ab rani, nur haleeda hakimi, hanafi ahmad damanhuri, suzana makpol & wan zurinah wan ngah. (2022). effects of age and tocotrienol-rich fraction on mitochondrial respiratory complexes in the hippocampus of rats. - sains malaysiana. 249-259.
nuraqila mohd murshid, nur fatin nabilah mohd sahardi and suzana makpol. (2025). advancing alzheimer’s disease modelling by developing a refined biomimetic brain microenvironment for facilitating high-throughput screening of pharmacological treatment strategies. - international journal of molecular sciences. 1 - 21.
rabiatul adawiyah razali, wan zurinah wan ngah, suzana makpol, daijiro yanagisawa, tomoko kato and ikuo tooyama. (2025). shifting perspectives on the role of tocotrienol vs. tocopherol in brain health: a scoping review. - international journal of molecular sciences. 1 - 58.
a. atikah, m. suzana, w.a.h. wan haslina, norshamsiah, m. mushawiahti, k.s.s. birinder, s.f. tang, m.l.c. bastion. (2025). randomised controlled trial on effects of topical insulin compared to artificial tears and normal saline on tear inflammatory mediator levels and clinical parameters in diabetics with dry eye disease. - contact lens & anterior eye. 1 - 8.
nurul tihani kamarulzaman, suzana makpol. (2025). the link between mitochondria and sarcopenia. - journal of physiology and biochemistry. 1 - 20.
noradliyanti rusli, chen fei ng, suzana makpol, yin ping wong, isma liza mohd isa, rabani remli . (2024). antioxidant effect in diabetic peripheral neuropathy in rat model: a systematic review. - antioxidants . 1 - 21.
amnani aminuddin, eng wee chua, chee-onn leong, suzana makpol, pei yuen ng. (2021). potential use of a heat shock protein 90 inhibitor, geldanamycin, in combination therapy with cisplatin in oral squamous cell carcinoma. - mspp 34th scientific meeting 2021. 61-62.
yasmin anum mohd yusof, junaidah@maimunah hassan basri, nor ashiken mokti, suhana mohd saad, suhaniza sulaiman, nur sajaratul binti yahya, emey suhana mohd azamai, suzana makpol, wan zurinah wan ngah. (2011). chlorella vulgaris : a miracle plant?. - 4th international conference on modeling, simulation and applied optimization, icmsao 2011. .
suzana makpol, nur fathiah abdul sani. (2022). penentuan kerosakan dna menggunakan kaedah asai komet. - . 115-127.
tan jen kit, suzana makpol. (2022). pengukuran aktiviti kompleks mitokondria dalam otak tikus. - . 74-84.
suzana makpol, nur fathiah abdul sani. (2022). pengukuran peroksidasi lipid menggunakan sitometri aliran dengan kaedah pewarnaan pendarfluor c11-bodipy 581/591. - . 50-58.
norwahidah abdul karim, hazirah hassan, suzana makpol, fazaine zakaria. (2024). mitokondria dan gangguan spektrum autisme: madu kelulut sebagai rawatan alternatif. - . .
suzana makpol, nur fathiah abdul sani. (2022). penentuan kerosakan dna menggunakan kaedah asai komet. - . 115-127.
tan jen kit, suzana makpol. (2022). pengukuran aktiviti kompleks mitokondria dalam otak tikus. - . 74-84.
suzana makpol, nur fathiah abdul sani. (2022). pengukuran peroksidasi lipid menggunakan sitometri aliran dengan kaedah pewarnaan pendarfluor c11-bodipy 581/591. - . 50-58.
goon jo aan, suzana makpol, zakiah jubri. (2022). panduan pengukuran status oksidatif. - . 1.
goon jo aan, amira nabila amir razak, suzana makpol, nor faeizah ibrahim, nur fathiah sani, amilia aminuddin, mohd heikal mohd yunus, chin kok yong, munirah mansor, wan zurinah wan ngah. (2025). second interim report for clinical trial: a randomized, double-blinded, placebo-controlled study to evaluate the efficacy of oral supplementation of tocotrienol rich fraction (davoslife e3 complete). - . .
anika tabassum, siti liyana saud gany, jen kit tan, suzana makpol. (2025). untargeted liver metabolites profiling and oxidative stress and inflammatory markers expression in sprague dawley rats supplemented with palm tocotrienol-rich fraction and its effect on hepatic changes during ageing. - 5th international conference on advances in medical science 2025. .
tan jen kit;suzana binti makpol;norfilza mohd mokhtar;goon jo aan;khairul najmi bin muhammad nawawi. (2024). exploring the roles of mirnas on lipidome of metabolic-associated fatty liver disease (mafld) cell models. - . .
jen kit tan, kartthigeen tamel selvan, ayaka nakashima, kengo suzuki, yu inaba, jo aan goon, hiroshi tsugawa, suzana makpol. (2024). lipid-lowering effects of microalgae extracts on a cell model of nonalcoholic fatty liver disease (nafld). - global algae summit 2024. .
jen kit tan, kartthigeen tamel selvan, ayaka nakashima, kengo suzuki, yu inaba, jo aan goon, hiroshi tsugawa, suzana makpol. (2024). lipidomics profiling of nafld cells treated with aurantiochytrium sp. extract. - third international lipidomics society conference & smart symposium on structurallipidomics. .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| TOCOTRIENOL AS A SENOLYTIC AGENT: A PHASE 2 CLINICAL TRIAL | malaysian palm oil board | 65.3% (2022-11-29 sehingga 2027-01-30) |
| TOCOTRIENOL AS A SENOLYTIC AGENT: A PHASE 2 CLINICAL TRIAL | davos life science sdn bhd | 65.3% (2022-11-29 sehingga 2027-01-30) |
| RELATIONSHIP BETWEEN GUT AND NASAL MICROBIOME PROFILES WITH T-HELPER PATHWAYS IN PERSISTENT MODERATE-SEVERE ALLERGIC RHINITIS CHILDREN WITH VITAMIN D SUPPLEMENTATION | pharma nord sdn bhd | 82.8% (2023-07-24 sehingga 2026-01-23) |
| EXPLORING NEURONAL EXPANSION BY PHOENIXIN IN PARKINSON`S DISEASE IN VITRO MODEL | monash university | 75.4% (2023-10-01 sehingga 2026-03-31) |
| CHARACTERISATION OF GUT MICROBIOME IN AGEING AND ITS MODULATION BY GINGER EXTRACTS IN RATS ANIMAL MODEL | am zaideen ventures sdn bhd | 96.2% (2022-10-01 sehingga 2025-09-30) |