prof. dr. suzana binti makpol

pensyarah universiti

jabatan biokimia

No. rasmi:
UKM : 03 8921 5555



   Biografi/ Biography :
  • Suzana binti Makpol is a Professor of Biochemistry at Faculty of Medicine, Universiti Kebangsaan Malaysia. She graduated from Universiti Kebangsaan Malaysia with Bachelor of Science Hons (Clinical Biochemistry) in 1992 and obtained her PhD (Medical Biochemistry) from the same university in 1997. She then went to Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan in year 2000 for research training and did an attachment at Linus Pauling Institute, Oregon State University, USA in 2008. Professor Makpol has been investigating the molecular changes that occur with ageing and elucidating the molecular mechanisms of natural compounds such as palm tocotrienols, microalgae Chlorella vulgaris, gelam honey, Piper betle and Zingiber officinale Roscoe (ginger) in delaying ageing with emphasis on intracellular signaling pathways and its regulation by genes, transcription factors and micro RNAs. In her studies, she has been using stress-induced premature senescence (SIPS) model of human diploid fibroblasts, replicative senescence model of human diploid fibroblasts, and myoblasts which represent cellular ageing besides the animal model. She has also developed the in vitro model of Alzheimer’s disease carrying the double Swedish/Indiana mutations. She has published more than 100 papers in peer-reviewed international journals and presented more than 150 seminar papers in local and international conferences. She has held many research grants and is currently involved in several research projects.

  • khaizurin binti tajul arifin;suzana binti makpol.  (2020).  the mechanism of antiaging effect of saccharomyces cerevisiae (sc) extract on aged human dermal fibroblasts.  -

     

    nurhazirah zainul azlan, norzana abd ghafar, yasmin anum mohd yusof, suzana makpol.  (2020).  toxicity study of chlorella vulgaris water extract on female sprague dawley rats by using the organization for economic cooperation and development (oecd) guideline 420.  - journal of applied phycology.  3063-3075. 

     

    suzana makpol, nur fathiah abdul sani, nur haleeda hakimi, nazirah ab rani, siti nor asyikin zajkaria, ahmad fais abd rasid, geetha gunasekaran, nur fatin nabilah mohd sahardi, jen kit tan, norzana abd ghafar and mariam firdhaus mad nordin.  (2020).  zingiber officinale roscoe prevents dna damage and improves muscle performance and bone integrity in old sprague dawley rats.  - evidence-based complementary and alternative medicine.  1-18. 

     

    asmaa abdullah, nuraqila mohd murshid, suzana makpol.  (2020).  antioxidant modulation of mtor and sirtuin pathways in age-related neurodegenerative diseases.  - molecular neurobiology.  5193-5207. 

     

    sheng zhang lim, suzana makpol, raja affendi raja ali, eng wee chua.  (2020).  revisiting the therapeutic monitoring of azathioprine in the management of inflammatory bowel disease.  - international research conference on pharmaceutical and allied sciences (ircpas 2020).  72-73. 

     

    asmaa abdullah, nuraqila mohd murshid, suzana makpol.  (2020).  antioxidant modulation of mtor and sirtuin pathways in age-related neurodegenerative diseases.  - molecular neurobiology.  5193-5207. 

     

    nurhazirah zainul azlan, yasmin anum mohd yusof and suzana makpol.  (2020).  chlorella vulgaris ameliorates oxidative stress and improves the muscle regenerative capacity of young and old sprague-dawley rats.  - nutrients.  1-22. 

     

    suzana makpol, nur fathiah abdul sani, nur haleeda hakimi, nazirah ab rani, siti nor asyikin zajkaria, ahmad fais abd rasid, geetha gunasekaran, nur fatin nabilah mohd sahardi, jen kit tan, norzana abd ghafar and mariam firdhaus mad nordin.  (2020).  zingiber officinale roscoe prevents dna damage and improves muscle performance and bone integrity in old sprague dawley rats.  - evidence-based complementary and alternative medicine.  1-18. 

     

    nur fatin nabilah mohd sahardi, faizul jaafar, mariam firdhaus mad nordin, and suzana makpol.  (2020).  zingiber officinale roscoe prevents cellular senescence of myoblasts in culture and promotes muscle regeneration.  - evidence-based complementary and alternative medicine.  1-13. 

     

    nurhazirah zainul azlan, norzana abd ghafar, yasmin anum mohd yusof, suzana makpol.  (2020).  toxicity study of chlorella vulgaris water extract on female sprague dawley rats by using the organization for economic cooperation and development (oecd) guideline 420.  - journal of applied phycology.  3063-3075. 

     

    faizul jaafar, lina wati durani, suzana makpol.  (2020).  chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts.  - molecular biology reports.  369-379. 

     

    goon jo aan, noralisa abdul karim, mohd shahril aszrin zainudin, suzana makpol.  (2019).  tocotrienol rich fraction modulates genes expression in oxidative stress-induced caenorhabditis e legans.  - bangladesh journal of medical science.  711-721. 

     

    khairunnisa' md yusof, suzana makpol, lye siew fen, rahman jamal, wan zurinah wan ngah.  (2019).  suppression of colorectal cancer cell growth by combined treatment of 6-gingerol and y-tocotrienol via alteration of multiple signalling pathways.  - journal of natural medicines.  745-760. 

     

    abdullah sani, nur fathiah, jaafar, faizul, hakimi, nur haleeda, ab rani, nazirah, zainol, murizal, mad nordin, mariam firdaus, abd ghafar, norzana, mohd yusof, yasmin anum, makpol, suzana.  (2018).  effect of zingiber officinale supplementation on muscle strength and performance of young male sprague dawley rats.  - medicine and health. 

     

    jaafar, faizul, abdul sani, nur fathiah, mad nordin, mariam firdaus, abd ghafar, norzana, mohd yusof, yasmin anum, makpol, suzana.  (2018).  ginger extract improves cell viability and prevents cellular ageing of human myoblasts in culture.  - medicine and health. 

     

    yasmin anum mohd yusof, junaidah@maimunah hassan basri, nor ashiken mokti, suhana mohd saad, suhaniza sulaiman, nur sajaratul binti yahya, emey suhana mohd azamai, suzana makpol, wan zurinah wan ngah.  (2011).  chlorella vulgaris : a miracle plant?.  - 4th international conference on modeling, simulation and applied optimization, icmsao 2011. 

     

    yasmin anum mohd yusof, junaidah@maimunah hassan basri, nor ashiken mokti, suhana mohd saad, suhaniza sulaiman, nur sajaratul binti yahya, emey suhana mohd azamai, suzana makpol, wan zurinah wan ngah.  (2011).  chlorella vulgaris : a miracle plant?.  - 4th international conference on modeling, simulation and applied optimization, icmsao 2011. 

     

    sheng zhang lim, suzana makpol, raja affendi raja ali, eng wee chua.  (2020).  revisiting the therapeutic monitoring of azathioprine in the management of inflammatory bowel disease.  - international research conference on pharmaceutical and allied sciences (ircpas 2020).  72-73. 

     

    khaizurin binti tajul arifin;suzana binti makpol.  (2020).  the mechanism of antiaging effect of saccharomyces cerevisiae (sc) extract on aged human dermal fibroblasts.  -

     

    jen kit tan, sakinah husna abdul razak, nur haleeda hakimi, nazirah ab rani, mohd hanafi ahmad damanhuri, suzana makpol, wan zurinah wan ngah.  (2020).  validation of a microplate assay for citrate synthase.  - 22nd medical & health research week.  47. 

     

    jen-kit tan, siti nor asyikin zakaria, geetha gunasekaran, nur fathiah abdul sani, faizul jaafar, zulzikry hafiz, ahmad imran zaydi amir hamzah, khairun nain nor aripin, mohd dzulkhairi mohd rani, nor azila noh, musalmah mazlan, mohd hanafi ahm.  (2019).  age-associated plasma metabolomic profile of healthy malay adults: a cross-sectional study in klang valley.  - international conference on ageing.  47. 

     

    faizul jaafar, nur fathiah abdul sani, mariam firdaus mad nordin, norzana abd ghafar, yasmin anum mohd yusof, suzana makpol.  (2019).  modulation of human myoblast cells viability and cellular senescence by ginger extract.  - international conference on ageing - ageing with dignity.  54. 

     
    Projek / Project Tempoh / Period Peranan / Role
    isolation, identification and characterization of lactic acid bacteria in tempoyak with anti-aging effect on c. elegans 12-11-202011-11-2022 Penyelidik Bersama
    elucidating the role of the kynurenine pathway in an acute delirium rat model 01-11-202031-10-2022 Penyelidik Bersama
    mechanism of intermittent fasting on high-fat-diet induced aggravation of β-amyloid deposition and inflammation in alzheimer’s disease 01-11-202031-10-2022 Penyelidik Bersama
    a randomized, double-blinded, placebo-controlled study to evaluate the efficacy of oral supplementation of tocotrienol-rich fraction (davoslife e3 complete) 01-10-202026-07-2023 Penyelidik Bersama
    (Tiada Rekod / No Record) 01-10-202030-09-2022 Penyelia
    examining the anti-inflammatory effects of b-hydroxybutyrate through the regulation of cx3cr1 expression levels in lipopolysaccharide-activated microglial cells 01-08-202031-01-2023 Penyelidik Bersama
    (Tiada Rekod / No Record) 02-07-202001-07-2022 Ketua Projek
    assessment of lidocaine toxicity in wide awake local anesthesia no tourniquet (walant) during radius plating 25-02-202024-07-2022 Penyelidik Bersama
    (Tiada Rekod / No Record) 18-02-202017-02-2022 Ketua Projek
    a randomized, double-blind, placebo-controlled study to evaluate the efficacy of oral supplementation of tocotrienol-rich fraction (davoslife e3 complete) 27-01-202026-01-2023 Penyelidik Bersama
    effects of topical insulin on levels of tear inflammatory mediators compared to standard artificial tears and normal saline in diabetics with dry eye disease 27-01-202026-01-2022 Penyelidik Bersama
    elucidating the molecular mechanisms of palm tocotrienol in promoting muscle regeneration in aged rats 01-10-201931-03-2022 Ketua Projek
    elucidation of lipid-lowering effect of gynura procumbens and its active compounds on low density lipoprotein receptor activity and molecular signaling in vitro and in vivo. 01-09-201930-11-2022 Penyelidik Bersama
    elucidating the metabolic networks of muscle mitochondria in rats with muscle ageing and its modulation by gingerol extract 01-09-201930-11-2022 Ketua Projek
    kesan suplementasi ekstrak halia (zingiber officinale)terhadap prestasi otot pada pesakit sarkopenia 01-08-201901-08-2021 Ketua Projek
    understanding the mitochondrial metabolome in hippocampus of rats with cognitive aging 01-01-201931-03-2022 Penyelidik Bersama
    determining the effect of tocotrienol-rich fraction on mitochondrial function hippocampus of middle-age rats 23-10-201822-04-2020 Penyelidik Bersama
    tajuk program: identifying degenerative diseases burden among elderly population in klang valley and innovative intervention modalities tajuk projek: effects of zingiber officinale active compounds on muscle ageing 01-09-201831-08-2020 Ketua Projek
    understanding the brain metabolome of scopolamine-induced memory impairment in zebrafish by lcms 15-08-201814-05-2021 Penyelidik Bersama
    ginger extract (zingiber officinale) for the promotion of muscle regeneration in elderly population 15-08-201814-02-2021 Ketua Projek
    kesan kemopencegah piper betle terhadap obesiti teraruh kolon kanser dalam tikus sprague dawley 06-07-201805-01-2019 Ketua Projek
    a case control study on association of cord blood and urinary phytoestrogens with abnormal external genitalia in male neonates 29-03-201828-11-2019 Penyelidik Bersama
    investigating the role of mitochondria function on age-associated adult hippocampal neurogenesis deficit and its modulation by gamma-tocotrienol 22-02-201821-02-2020 Penyelidik Bersama
    investigating the role of mitochondria function on age-associated adult hippocampal neurogenesis deficit and its modulation by gamma-tocotrienol 16-10-201715-04-2021 Penyelidik Bersama
    the mechanism of antiaging effect of saccharomyces cerevisiae (sc) extract on aged human dermal fibroblasts 16-10-201715-07-2020 Penyelidik Bersama
    determination of mitochondrial function underlying idiopathic autism spectrum disorders and its modulation by kelulut honey 28-09-201727-09-2020 Penyelidik Bersama
    evaluating of the safety and bioavailability of tocotrienol-rich fraction formulated into palm kernel olein carrier in rats 21-09-201720-03-2019 Ketua Projek
    identifying targetable molecules that regulate healthspan in caenorhabditis elegans 15-08-201714-02-2020 Penyelidik Bersama
    association of phytoestrogens and development of external genitalia in male newborns. 15-08-201714-02-2020 Penyelidik Bersama
    mechanism of wound healing properties of gelam honey in a human corneal cell reepithelialisation model 15-08-201731-01-2020 Penyelidik Bersama
    effect of palm tocotrienol on cutaneous wound healing in type ii diabetic mice 09-05-201708-05-2020 Ketua Projek
    effects of tocotrienol rich fraction (trf) and α - tocopherol (atf) in oxidative stress-induced human pbmc-derived osteoclast in vitro 26-01-201725-01-2019 Penyelidik Bersama
    penyasaran myomirs oleh chlorella vulgaris dalam peningkatan pertumbuhan semula otot rangka 18-08-201617-08-2019 Ketua Projek
    pengekspresan mirna dan gen sasaran di dalam model in vitro penyakit alzheimer serta modulasinya oleh isomer tokoferol 11-08-201610-08-2019 Ketua Projek
    the role of mglu5-pkc epsilon-erk1/2 molecular pathway in rat basolateral and central amygdalar glutamatergic hyperexcitability during ethanol withdrawal induced anxiety 01-08-201631-01-2020 Penyelidik Bersama
    elucidation of mitochondrial biomarkers underlying idiopathic autism spectrum disorders and its modulation by gelam honey 01-08-201631-07-2018 Penyelidik Bersama
    modulation of basolateral and central amygdalar mglu5 hyperexcitability by erk1/2 during ethanol withdrawal induced anxiety. 01-05-201631-10-2018 Penyelidik Bersama
    modulation of tocotrienol rich fraction on the differential genes expressions on autistic lymphoblastoid cell lines under oxidative stress condition 01-01-201630-06-2017 Penyelidik Bersama
    status oksidatif pada penyakit pramatang arteri koronari 15-06-201530-09-2016 Penyelidik Bersama
    kajian kesan suplimentasi fraksi kaya tokotrienol (trf) terhadap perubahan ekspresi protein jantung tikus teraruh iskemia-reperfusi sewaktu pelaziman iskemia 12-06-201511-06-2017 Penyelidik Bersama
    association of age associated decline in cognitive function with the plasma proteome 01-06-201531-05-2018 Ketua Projek
    the effect of tocotrienol rich fraction (trf) supplementation on cognitive functions and transcriptome profile in the hippocampus brain region of alzheimer’s disease mouse model 01-06-201530-11-2017 Penyelidik Bersama
    role of tocotrienol-rich fraction (trf) in promoting muscle regeneration of human myoblast for prevention of sarcopenia 30-04-201529-04-2016 Ketua Projek
    kajian modulasi tapak jalan sirtuin dan mtor oleh vitamin e dalam model sel penyakit alzheimer 12-03-201511-03-2018 Ketua Projek
    kajian modulasi fungsi mitokondria oleh vitamin e dalam penyakit alzheimer 26-01-201525-01-2018 Ketua Projek
    targeting myomirs by chlorella vulgaris for the promotion of muscle regeneration 01-12-201431-05-2018 Ketua Projek
    therapeutic implications of piper betle extract in obesity associated colon cancer. 10-11-201409-11-2017 Penyelidik Bersama
    signalling molecule in ischemic-reperfusion pre and post-conditioning in culture and animal study. 01-11-201431-10-2017 Penyelidik Bersama
    keberkesanan dan kelestarian intervensi gaya hidup sihat untuk penghuni felda dewasa yang mengalami pra-diabetes : menggunakan pendekatan model sosial ekologi dan holistik 30-10-201429-10-2017 Penyelidik Bersama
    penyasaran myomirs oleh fraksi kaya tokotrienol untuk penggalakkan pembezaan otot 14-08-201413-08-2017 Ketua Projek
    insentif penyelidikan: suzana binti makpol 01-06-201431-05-2016 Ketua Projek
    aras hs_crp pada pesakit arteri koronari pramatang 01-04-201431-03-2015 Penyelidik Bersama
    integrative epigenetic regulation of cognitive function and neurodegeneration during aging 01-01-201431-12-2015 Ketua Projek
    bantuan kewangan bahan penyelidikan (bkbp): suzana binti makpol 01-01-201431-03-2015 Penyelia
    elucidation of mechanisms of action of palm tocotrienol to improve acceptance and enhance its marketability 01-08-201301-01-2016 Penyelidik Bersama
    mekanisme perlindungan fraksi kaya tokotrienol (trf), α-tokoferol dan n-asetilsistein (nac) dalam mencegah penuaan sel mioblas manusia. (protective mechanism of tocotrienol-rich fraction (trf), α-tocopherol and n-acetylcystein (nac) in preventing cellu 01-06-201331-05-2016 Ketua Projek
    modulation of senescence-associated micrornas by tocotrienol-rich fraction to prevent replicative senescence of human diploid fibroblasts 01-05-201331-10-2015 Ketua Projek
    effects of platinum nanoparticles in hydrogen peroxide treated human airway cells through epithelial sodium channel and pkc pathway 01-04-201331-03-2016 Penyelidik Bersama
    elusidasi mekanisme anti-angiogenik fraksi kaya tokotrienol (trf) dlama mengurangkan keterukan psoriasis 01-03-201331-03-2016 Ketua Projek
    bantuan kewangan bahan penyelidikan: suzana binti makpol 01-03-201328-02-2014 Penyelia
    profil keradangan dalam pesakit arteri koronari pramatang dan pesakit arteri koronari 01-01-201331-03-2014 Penyelidik Bersama
    critical factors in muscle degeneration: from molecules to community 01-08-201231-01-2015 Ketua Projek
    unravelling the transitional events of normal to pathological aging leading to cognitive decline 01-07-201231-12-2016 Ketua Projek
    modulasi pengekspresan sirti oleh fraksi-kaya tokotrienol (trf) untuk mencegah penuaan replikatif sel diploid fibroblas manusia (hdfs) 01-05-201230-06-2014 Ketua Projek
    comparing tocophenol and tocotrienol tri e supplementation in order adults: a clinical trial 01-04-201230-09-2014 Penyelidik Bersama
    effect of gelam honey in uv a-induced photoaging in human skin fibroblast cells 01-04-201231-03-2013 Ketua Projek
    modulation of cell cycle profiles and telomere length by chlorella vulgaris (cv) to prevent replicative senescence of human diploid fibroblasts (hdfs) 01-01-201230-04-2013 Ketua Projek
    comparing supplementation of palm tocotrienol-rich fraction with alpha-tocopherol by transcriptomics and proteomics analysis and improvements in redox status 01-11-201131-12-2014 Penyelidik Bersama
    anti aging mechanism of gamma tocotrienol via apoptotic pathway in stress-induced premature sen (sips) model 01-09-201131-08-2013 Ketua Projek
    transcriptomics approach in the study of chemobrain 08-08-201108-02-2013 Penyelidik Bersama
    a system biology approach to the study of aging: modulation by palm vitamin e 01-08-201131-07-2013 Penyelidik Bersama
    pencegahan penuaan selular melaui tapak jalan proliferasi & inflamasi sel diploid fibroblas manusia 01-07-201130-06-2013 Ketua Projek
    the reparative roles of human adipose-derived stem cells in chemical-induced hepatocytes injury 20-08-201019-02-2013 Penyelidik Bersama
    development of in vitro reconstructed asian skin equivalent model as testing system for industrial usage 20-08-201019-02-2013 Ketua Projek
    antioxidant property and elucidation of anti inflammatory mechanism of nenas honey in rats 01-05-201030-04-2013 Penyelidik Bersama
    kesan fraksi kaya tokotrienol (trf) terhadap penuaan kulit aruhan sinar ultraungu pada sel fibroblas 01-05-201030-04-2011 Ketua Projek
    anti inflammatory mechanism of honey may involve inactivation of inflammatory marker, nuclear factor kappa-b (nf-kb) 15-03-201014-12-2012 Penyelidik Bersama
    anti-aging mechanism of y-tocotrienol via apoptotic pathway in stress-induced premature senescence (sips) model 15-03-201014-09-2012 Ketua Projek
    modulation of functional protein expression in mitochondria of senescent fibroblasts by tocotrienol rich fraction (trf) 15-03-201014-03-2012 Penyelidik Bersama
    biomarker-based identification of chemopreventive compounds against cancers of the brain and colon 01-01-201031-12-2016 Penyelidik Bersama
    gamma-tocotrienol modulates gene expression resulting in increased cell dealth of hepg2 cells 01-11-200930-04-2012 Penyelidik Bersama
    mekanisme anti penuaan oleh alpha tokotrienol melalui silencing rna (sirna) dan regulasi kitar sel 01-11-200931-10-2011 Ketua Projek
    penentuan mekanisme anti-penuaan alpha-tokutrienol melalui tapak jalan apoptosis pada model 'stress-induced premature senescence (sips)' 01-11-200931-10-2011 Ketua Projek
    molecular mechanism of y-tocotrienol in the prevention of cellular ageing 01-11-200931-10-2011 Ketua Projek
    madu melindungi kerosakan dna aruhan radiasi gama pada sel fibroblas kulit 01-10-200930-09-2012 Penyelidik Bersama
    replicative senescence mechanism in human adipose-derived stem cell 01-08-200931-07-2011 Penyelidik Bersama
    partial endocrine deficiency syndromes and development of an oxidative status device for the aging men 01-07-200930-06-2012 Penyelidik Bersama
    evaluation of skin product: animal and human studies 01-12-200823-12-2010 Penyelidik Bersama
    modulation of signalling cascade proteins and rna expressions by tocotrienal rich fraction(trf) in oxidate stress induced aging in c. elegans 01-08-200831-07-2011 Penyelidik Bersama
    pengenalpastian perubahan protein dalam "stress-induced premature senescence (sips)" pada fibroblast 01-08-200830-06-2010 Penyelidik Bersama
    chorella vulgaris memodulasi pengekspresan gen pada sel limfosit individu berbeza peringkat umur 01-06-200801-05-2011 Penyelidik Bersama
    age-related changes in mitochondrial function and its modulation by antioxidants 01-10-200731-03-2011 Penyelidik Bersama
    effect of age on genes related to antioxidant in c elegens and primary culture of human skin fibrolast 01-10-200730-09-2010 Ketua Projek
    identification of proteome changes in stress-induced premature senescence(sips) fibroblast 01-09-200731-08-2010 Penyelidik Bersama
    supression of nuclear factor-kb (nf-kb) and histone deacetylase (hdac) activity is the mechanism of action of chemoprevention by chlorella vulgaris 01-09-200730-06-2010 Penyelidik Bersama
    penentuan penanda penuaan sel pada model stress-induced premature senescene(sips) 01-06-200701-05-2009 Ketua Projek
    expression of replicative senescence-associated genes in human dermal fibroblasts treated with gamma-tocotrienol 01-12-200631-05-2009 Ketua Projek
    biotechnology of mass culture of microalgae chlorella vulgaris and the determination of nutrient and antioxidant components 01-12-200631-05-2009 Penyelidik Bersama
    gamma-tocotrienol modulates oxidative stress response and gene expression of human lymphocytes from different age groups 01-12-200628-02-2009 Penyelidik Bersama
    nuclear factor kb(nf-kb) and activator protein-1(ap-1) modulation of dna repair in aliver cancer cell line 01-11-200631-10-2009 Penyelidik Bersama
    identification of cellular senescence markers in stress-induced premature senescence (sips) model 01-11-200631-10-2009 Ketua Projek