prof. madya dr. mohd firdaus bin mohd raih

pensyarah universiti

jabatan fizik gunaan

No. sambungan :  0389215961

No. rasmi:
UKM : 03 8921 5555



   Biografi/ Biography :
  • My research is primarily directed at understanding molecular function regulation by exploring the mechanistic atomic level interactions that affect function and/or effect molecular level switching as well as the associated regulatory pathways. To accomplish this, my research group studies the structure, function and evolution of biological macromolecules to compare how the atomic level differences can result in different functions by effecting regulatory or mechanistic changes. We source our data from public repositories such as GenBank and the Protein Data Bank as well as by generating internal data such as genome sequences, transcriptome sequences and methylome sequences from specific experiments. The approaches employed in exploring and investigating these datasets primarily involve bioinformatics, computational biology and genomics but also extend to structural biology (mainly X-ray crystallography), synthetic biology and systems biology. The insights revealed from these investigations can provide clues as to how molecular level regulation and responses in living systems are carried out that eventually lead to an organism’s capacity to adapt to extreme (ie. extremophiles) or diverse environments (ie. such as a bacterial pathogen or parasite adapting to a host) as well as the discovery of novel factors associated with pathogenesis (toxins and pathogenesis/virulence regulation systems). Our understanding of the atomic level interactions that define specific biological mechanisms have led to the development of applications for drug repositioning and tools for the synthetic design of nucleic acid self-assembling structures.

  • xin-wei lee, su datt lam, mohd firdaus-raih, kiew-lian wan.  (2020).  molecular characterisation of eimeria tenella porin, a potential anticoccidial drug target.  - sains malaysiana.  755-764. 

     

    ng chyan leong;sheila nathan;mohd firdaus bin mohd raih.  (2020).  functional characterization of burkholderia pseudomallei hypothetical proteins that have endonuclease structure fold.  -

     

    sheila nathan;mohd firdaus bin mohd raih.  (2020).  elucidating the mechanisms of diabetes-melioidosis co-morbidity.  -

     

    shuhaimi, n., shaibullah, s., firdaus-raih, m., nathan, s., ng, c. l..  (2020).  conformation of hypothetical protein bpsl1038 is affected by the concentration of sodium chloride.  - asian regional conference on systems biology 2020 (arcsb2020).  82. 

     

    nur syatila ab ghani, reeki emrizal, haslina makmur, mohd firdaus raih.  (2020).  side chain similarity comparisons for integrated drug repositioning and potential toxicity assessments in epidemic response scenarios: the case for covid-19.  - computational and structural biotechnology journal.  2931-2944. 

     

    nur syatila ab ghani, reeki emrizal, haslina makmur, mohd firdaus raih.  (2020).  side chain similarity comparisons for integrated drug repositioning and potential toxicity assessments in epidemic response scenarios: the case for covid-19.  - computational and structural biotechnology journal.  2931-2944. 

     

    shuhaila mat-sharani, and mohd firdaus-raih.  (2019).  computational discovery and annotation of conserved small open reading frames in fungal genomes.  - bmc bioinformatics. 

     

    nur syatila ab ghani effirul ikhwan ramlan mohd firdaus-raih.  (2019).  drug reposer: a web server for predicting similar amino acid arrangements to known drug binding interfaces for potential drug repositioning.  - nucleic acids research.  350-356. 

     

    hazrina yusof hamdani, mohd firdaus-raih.  (2019).  identification of structural motifs using networks of hydrogen-bonded base interactions in rna crystallographic structures.  - crystals.  1-14. 

     

    mohd firdaus-raih, noor haza fazlin hashim, izwan bharudin, mohd faizal abu bakar, kie kyon huang, halimah alias, bernard k. b. lee, mohd noor mat isa, shuhaila mat-sharani, suhaila sulaiman, lih jinq tay, radziah zolkefli,yusuf muhammad noor, douglas sie.  (2018).  the glaciozyma antarctica genome reveals an array of systems that provide sustained responses towards temperature variations in a persistently cold habitat.  - plos one.  1-18. 

     

    xin-wei lee, su datt lam, mohd firdaus-raih, kiew-lian wan.  (2020).  molecular characterisation of eimeria tenella porin, a potential anticoccidial drug target.  - sains malaysiana.  755-764. 

     

    hazrina yusof hamdani, mohd firdaus-raih.  (2018).  analisis dan penyaringan data lewah interaksi kelompok bes berikatan hidrogen dalam struktur rna 3-dimensi.  - sains malaysiana. 

     

    ping-ping yao, mohd firdaus raih, hasidah mohd sidek, noor embi & kiew-lian wan.  (2016).  pencirian molekul glikogen sintase kinase-3 dari eimeria tenella.  - sains malaysiana.  1947-1957. 

     

    jumaat haji adam, mohd afiq aizat juhari, rahmah mohamed, nor azilah abdul wahab, syamsurina arshad, mohd paiz kamaruzaman, mohd firdaus mohd raih & kiew-lian wan.  (2016).  rafflesia tuanku-halimii n. (rafflesiaceae), a new species from peninsular malaysia.  - sains malaysiana.  1589-1595. 

     

    noor, y.m., samsulrizal, n., jema`on, n.a., low, k.o., ramli, a.n., alias, n.i., damis, s.i., fuzi, s.f., isa, m.n., murad, a.m.a., raih, m.f.m., bakar, f.d.a, najimudin, n., mahadi, n.m., illias, r.m.  (2014).  a comparative genomic analysis of the alkalitolerant soil bacterium bacillus lehensisg1.  - gene.  545: 253-261. 

     

    siuk-mun ng, xin-wei lee, kiew-lian wan & mohd firdaus-raih.  (2015).  comparative differential gene expression analysis of nucleus-encoded proteins for rafflesia cantleyi against arabidopsis thaliana.  - the 2015 ukm fst postgraduate colloquium.  030020(1-6). 

     

    intan azlinda ramlee, mohd firdaus-raih & kiew-lian wan.  (2015).  identification and characterization of secreted proteins in eimeria tenella.  - aip conference proceedings.  030023. 

     

    noor munyati othman, ahmad luqman abdul fatah, mohd al akmarul fizree bin md piji, effirul ikhwan ramlan and mohd firdaus raih.  (2015).  identification and cloning of four riboswitches from burkholderia pseudomallei strain k96243.  - the 2015 ukm fst postgraduate colloquium.  1-5. 

     

    nur syamimi yusoff, nadzirah damiri, mohd firdaus-raih.  (2014).  identification of the conserved hypothetical protein bpsl0317 in burkholderia pseudomallei k96243.  - aip conference proceeding - the 2014 ukm fst postgraduate colloquium.  544-548. 

     

    siuk-mun ng, xin-wei lee, kiew-lian wan & mohd firdaus-raih.  (2015).  comparative differential gene expression analysis of nucleus-encoded proteins for rafflesia cantleyi against arabidopsis thaliana.  - the 2015 ukm fst postgraduate colloquium.  030020(1-6). 

     

    intan azlinda ramlee, mohd firdaus-raih & kiew-lian wan.  (2015).  identification and characterization of secreted proteins in eimeria tenella.  - aip conference proceedings.  030023. 

     

    noor munyati othman, ahmad luqman abdul fatah, mohd al akmarul fizree bin md piji, effirul ikhwan ramlan and mohd firdaus raih.  (2015).  identification and cloning of four riboswitches from burkholderia pseudomallei strain k96243.  - the 2015 ukm fst postgraduate colloquium.  1-5. 

     

    nur syamimi yusoff, nadzirah damiri, mohd firdaus-raih.  (2014).  identification of the conserved hypothetical protein bpsl0317 in burkholderia pseudomallei k96243.  - aip conference proceeding - the 2014 ukm fst postgraduate colloquium.  544-548. 

     

    shuhaila mat-sharani, doris hx quay, chyan l ng & mohd firdaus-raih.  (2019).  encyclopedia of bioinformatics and computational biology.  - 7. 

     

    suhaila sulaiman, nur s yusoff, ng s mun, haslina makmur, mohd firdaus-raih.  (2018).  encyclopedia of bioinformatics and computational biology.  - 11. 

     

    munyati othman, siuk m ng, mohd firdaus-raih.  (2018).  encyclopedia of bioinformatics and computational biology.  - 5. 

     

    mohd firdaus-raih, nur syatila abdul ghani.  (2018).  encyclopedia of bioinformatics and computational biology.  - 10. 

     

    nur sa ghani, shandar ahmad, mohd firdaus-raih.  (2018).  encyclopedia of bioinformatics and computational biology.  - 9. 

     

    chyan leong ng & mohd firdaus-raih.  (2019).  encyclopedia of bioinformatics and computational biology.  - 14. 

     

    shuhaila mat-sharani, doris hx quay, chyan l ng & mohd firdaus-raih.  (2019).  encyclopedia of bioinformatics and computational biology.  - 7. 

     

    munyati othman, siuk m ng, mohd firdaus-raih.  (2018).  encyclopedia of bioinformatics and computational biology.  - 5. 

     

    mohd firdaus-raih, nur syatila abdul ghani.  (2018).  encyclopedia of bioinformatics and computational biology.  - 10. 

     

    nur sa ghani, shandar ahmad, mohd firdaus-raih.  (2018).  encyclopedia of bioinformatics and computational biology.  - 9. 

     

    idayu maarof & mohd firdaus raih.  (2016).  the doctor is sick.  - 128. 

     

    fadhar, n. f., shuhaimi, n., raih, m. f., nathan, s., ng, c. l..  (2020).  overexpression and purification of bpsl0738, a hypothetical protein potentially involves in host-pathogen interaction in burkholderia pseudomallei.  - asian regional conference on systems biology 2020 (arcsb2020).  111. 

     

    sheila nathan;mohd firdaus bin mohd raih.  (2020).  elucidating the mechanisms of diabetes-melioidosis co-morbidity.  -

     

    shuhaimi, n., shaibullah, s., firdaus-raih, m., nathan, s., ng, c. l..  (2020).  conformation of hypothetical protein bpsl1038 is affected by the concentration of sodium chloride.  - asian regional conference on systems biology 2020 (arcsb2020).  82. 

     

    ng chyan leong;sheila nathan;mohd firdaus bin mohd raih.  (2020).  functional characterization of burkholderia pseudomallei hypothetical proteins that have endonuclease structure fold.  -

     

    mohd firdaus bin mohd raih;wan kiew lian;zeti azura binti mohamed hussein;shairah binti abdul razak;nor azlan bin nor muhammad.  (2020).  a multi-transcriptome rna-sequencing approach for insights into understanding host-pathogen/parasite interactions and specific inter-species bacterial interactions.  -

     
    Projek / Project Tempoh / Period Peranan / Role
    investigating the effects of post annealing treatment towards the performance of chem-fet titanium oxide sensor for sodium and potassium ion sensing in aqueous solution 01-10-202030-09-2022 Penyelidik Bersama
    suisribo sebagai pengesan molekul and pengawalatur pelbagai gen 17-08-202016-02-2021 Ketua Projek
    merungkai enigma melioidosis melalui pencirian protein hipotetikal 17-08-202016-02-2021 Ketua Projek
    computational characterization of sars-cov-2 genomes and protein structures associated with covid-19 for prediction of evolutionary trajectory and identification of candidates for drug repurposing 01-08-202031-07-2021 Ketua Projek
    (Tiada Rekod / No Record) 10-03-2020 Penyelia
    (Tiada Rekod / No Record) 10-10-201908-10-2021 Ketua Projek
    computational structural and functional annotation of the glaciozyma antarctica proteome 01-10-201930-09-2021 Penyelidik Bersama
    genomic sequence diversity in the eimeria surface antigen superfamily 01-10-201930-09-2021 Penyelidik Bersama
    computational comparisons of rna 3d base arrangements to identify ligand binding sites in rna structures 01-10-201930-09-2021 Ketua Projek
    elucidating the molecular mechanism of il-37d in attenuating neuroinflammation in a retinoic acid-induced spina bifida mouse model 01-09-201930-11-2022 Penyelidik Bersama
    functional annotation of small open reading frames (sorfs) associated with adaptation strategies of burkholderia pseudomallei the causative pathogen of melioidosis. 01-09-201930-11-2022 Penyelidik Bersama
    insights into life as a single flower via comparative transcriptome analysis 01-09-201930-11-2021 Penyelidik Bersama
    structural and functional characterization of genes encoding hypothetical proteins but are essential for host infection in burkholderia pseudomallei 01-01-201931-03-2022 Penyelidik Bersama
    elucidating the mechanism of secretion for human pro-metastatic agr2 protein 14-12-201813-03-2021 Penyelidik Bersama
    in silico mapping of qtls associated with resistance against biotic and abiotic stresses 01-02-201831-01-2021 Penyelidik Bersama
    structure-function analysis of burkholderia essential proteins 01-01-201831-12-2021 Penyelidik Bersama
    elucidating the mechanisms of diabetes-melioidosis co-morbidity 16-10-201715-07-2020 Penyelidik Bersama
    functional characterization of burkholderia pseudomallei hypothetical proteins that have endonuclease structure fold 16-10-201715-07-2020 Penyelidik Bersama
    a multi-transcriptome rna-sequencing approach for insights into understanding host-pathogen/parasite interactions and specific inter-species bacterial interactions 16-10-201715-10-2019 Ketua Projek
    mapping the burkholderia pseudomallei transcriptional profile in different niches to understand pathogenicity 01-08-201631-01-2020 Penyelidik Bersama
    comparative genomics of rafflesia species 01-05-201631-10-2018 Penyelidik Bersama
    ganjaran penerbitan: mohd firdaus bin mohd raih 01-05-201630-04-2018 Ketua Projek
    burkholderia pseudomallei virulence: towards understanding pathogenesis and host-pathogen response 01-01-201630-06-2018 Penyelidik Bersama
    computational analysis and characterization of novel 3-dimensional motifs in proteins and complex rna structures 01-09-201528-02-2018 Ketua Projek
    penghasilan penerbitan berimpak tinggi di inbiosis 15-06-201530-09-2016 Penyelidik Bersama
    gene expression and protein-nucleic acid contacting patterns of dna-methylases 15-06-201530-09-2016 Ketua Projek
    tajuk program: gut microbiome: the exciting new frontier in understanding colorecteral cancer. tajuk projek: elucidating the colorecteral cancer gut microbiome 01-02-201531-07-2018 Penyelidik Bersama
    development and deployment of an implicit structure model based protein-dna binding site prediction application 16-12-201415-12-2016 Ketua Projek
    microbial methylomics: understanding methylation-mediated regulation in endemic model systems 01-08-201431-01-2017 Ketua Sub Projek
    engineering of a computational analysis and characterization platform for small 3-dimensional motifs in proteins and complex rna structures 01-08-201431-07-2016 Ketua Projek
    comparative morphologies and genomics of the rafflesiaceae (rafflesia and rhizanthes): uncovering molecular insights into the evolution of holoparasitism in peninsular malaysia and sarawak 01-07-201430-06-2017 Penyelidik Bersama
    comparative phylogenomic of selected burkholderia spp. smrt sequencing 01-04-201431-03-2015 Ketua Projek
    pengukuhan penerbitan dan program penyelidikan inbiosis 01-04-201431-03-2015 Penyelidik Bersama
    elucidating the functions of hypothetical proteins for application in therapeutics and prophylaxis 01-01-201430-06-2017 Ketua Projek
    dissecting the physiological and molecular mechanisms of phase synchronized bioluminescence in the fireflies 01-01-201431-12-2016 Penyelidik Bersama
    generation and characterization of the raflesia genome sequence 01-01-201431-12-2016 Penyelidik Bersama
    gaussian noise model for reconstruction of gene regulatory networks in solving network structures prediction problems 16-12-201315-12-2016 Penyelidik Bersama
    structural and functional genomics of glycoside and peptide hydrolases from the extremophiles glaciozyma antarctica and bacillus lehensis g1 for the biobased economy. 01-08-201331-07-2017 Penyelidik Bersama
    structural genomics of ribonucleoproteins and small hypothetical proteins 01-08-201331-07-2017 Ketua Projek
    characterization of novel small non-coding rna`s from burkholderia pseudomellei: possible implication towards understanding the control and regulation of environmental adaption bacteria 01-04-201331-03-2016 Ketua Projek
    research, technology transfer and commercialization of livestock vaccines and plant tissue culture products 01-03-201331-12-2015 Penyelidik Bersama
    bantuan kewangan bahan penyelidikan: mohd firdaus bin mohd raih 01-03-201328-02-2014 Penyelia
    exploring the molecular mechanisms of potential unconventional drug targets 01-01-201331-03-2014 Penyelidik Bersama
    comparative genomics of clinical and environmental burkholderia pseudomallei to understand emergence of virulence 01-10-201230-03-2016 Penyelidik Bersama
    understanding bacterial intracellular survival and emergence of virulence 01-06-201230-11-2015 Penyelidik Bersama
    exploring the diversity of function and regulation mechanisms for small rnas (srnas) of bacterial pathogens 01-06-201231-05-2015 Ketua Projek
    virulence genes via host pathogen 01-05-201230-04-2014 Penyelidik Bersama
    high throughput screen of systhetic and small molecules as anti-infectives 01-12-201131-05-2015 Penyelidik Bersama
    omp-based melioidosis vaccine development 01-12-201130-11-2013 Penyelidik Bersama
    exploring the diversity of function and regulation mechanisms for srnas of acterial pathogens 08-08-201107-08-2012 Ketua Projek
    understanding bacterial pathogenesis and in vivo survival by bukholderia spp 08-08-201107-08-2012 Penyelidik Bersama
    exploring the frontier of pathogenesis emergence: charting the evolution of bacterial 01-08-201131-07-2013 Penyelidik Bersama
    perlombongan gen bakteria dan dinoflagelat marin untuk penjanaan ilmu dan aplikasi bioteknologi 01-08-201131-07-2013 Penyelidik Bersama
    unveiling the functions of taxonomically conserved and unique hypothetical proteins in bacterial pathogens 21-06-201120-06-2014 Ketua Projek
    structural genomics of the extremophilic microbes leucosporidium antarcticum and bacillus lehensis g1 01-01-201131-12-2015 Penyelidik Bersama
    next generation genomics of malaysian bioresources: exploring the enigmatic biology of rafflesia sp., garcinia mangostana and liches via transcriptome and metagenome 01-10-201031-12-2013 Penyelidik Bersama
    pencarian fungsi bagi struktur protein yang tidak dikenalpasti fungsinya melalui pembandingan skala besar struktur 3-dimensi 01-06-201030-06-2012 Ketua Projek
    computational analyses of nucleotide base interaction in rna three-dimensional structures 25-05-201024-11-2011 Ketua Projek
    screening for gsk3 inhibitors and evaluation of potential therapeutic agents from natural products against malaria and meliodosis 01-11-200930-11-2012 Penyelidik Bersama
    structural bioinformatics: computational analysis of hydrogen bonded nucleotide base interactions in 01-08-200931-01-2012 Ketua Projek
    exploring selected indigenous marine and terrestial organisma of strategic and commercial relevance using genomic and glycomic approaches 01-07-200930-06-2012 Penyelidik Bersama
    systems biology of psychrophilic yeasts for novel biotecnology : exploring rna biology 01-04-200931-12-2013 Ketua Projek
    kajian rna jujukan pendek tidak dikodkan dalam organisma-organisma model: burkholderia pseudomallei, eimeria tenella, plasmodium falciparum dan lates calcarifer 01-06-200830-06-2012 Ketua Projek
    pembangunan proses penghasilan produk untuk melalui pendekatan biologi sintetik 01-06-200831-05-2011 Penyelidik Bersama
    bioethanol derivatives and biofuel applications 01-01-200830-06-2012 Penyelidik Bersama
    structural genomics of burkholderia pseudomallei essential genes and transcription factors 02-01-200731-12-2010 Penyelidik Bersama