pensyarah universiti
pusat kajian toksikologi & risiko kesihatan (core)
satirah@ukm.edu.my
Biografi/ Biography :
Saya telah menjalani pengkhususan di dalam bidang fisiologi dan farmakologi kardiovaskular, dengan penumpuan ke atas mekanisme kecederaan kardiovaskular dan potensi intervensi terapeutik. Penyelidikan kami menggunakan pelbagai jenis model haiwan, termasuk kecederaan jantung yang disebabkan oleh isoprenalin dan nikotin, untuk menyelidiki laluan yang terlibat dalam kerosakan jantung. Salah satu bidang minat utama saya ialah potensi terapeutik tumbuhan perubatan dan sebatian bioaktif. Kajian kami telah meneroka kesan ekstrak kaya antosianin daripada roselle (Hibiscus sabdariffa), glikosida kardio 17β-neriifolin daripada Cerbera odollum, dan S-allylcysteine daripada bawang putih, dengan tujuan untuk mengenal pasti sifat kardioprotektif dan mekanisme tindakannya. Penyelidikan ini telah menyumbang kepada pemahaman dan bukti bahawa penggunaan sebatian semula jadi mempunyai potensi di dalam terapi kardiovaskular. Di dalam makmal, kami mempelopori pelbagai teknik, terutamanya sistem perfusi jantung terasing menggunakan alat Langendorff—satu teknik yang satu-satunya aktif di dalam bidang penyelidikan kardiovaskular di Malaysia. Selain itu, kami juga mengkaji kereaktifan vaskular, tapak jalan protein, dan ekspresi gen untuk lebih memahami fungsi dan penyakit kardiovaskular.
I specialize in cardiovascular physiology and pharmacology, with a strong focus on unravelling the mechanisms of cardiovascular injury and exploring potential therapeutic interventions. Our research involves utilizing animal models, such as isoprenaline-induced and nicotine-induced cardiac injury, to gain insights into the intricate pathways of heart damage. An area of particular interest is the therapeutic potential of medicinal plants and bioactive compounds. Our work has explored the effects of anthocyanin-rich extracts from roselle (Hibiscus sabdariffa), the cardiac glycoside 17β-neriifolin from Cerbera odollum, and S-allylcysteine, a sulfur-containing compound derived from garlic. These studies aim to uncover their cardioprotective properties and mechanisms of action. I am proficient in advanced laboratory techniques, with a primary focus on the isolated perfused heart system using the Langendorff apparatus—a technique that stands out as the only active cardiovascular research approach in Malaysia. Additionally, I am involved in research on vascular reactivity and investigating protein and gene expression pathways to deepen our understanding of cardiovascular regulation and potential drug targets.
urip harahap, rony abdi syahputra, amer ahmed, azhari nasution, wenny wisely, maureen lazurit sirait, aminah dalimunthe, satirah zainalabidin, nurpudji astuti taslim, fahrul nurkolis, bonglee kim. (2024). current insights and future perspectives of flavonoids: a promising antihypertensive approach. - phytotherapy research. 3146-3168.
mohd kaisan bin mahadi;satirah binti zainalabidin;chua eng wee. (2024). vagus nerve stimulation: investigation on cholinergic anti-inflammatory activity and macrophage polarization in rats with induced myocardial infarction.. - . .
muhamad adib abdul ghani, munirah majed alkharji, wan nur izzah shazana wan nawi, ahmad syafi ahmad rushdan, jalifah latip, azizah ugusman, mohd kaisan mahadi, satirah zainalabidin. (2023). carvacrol ameliorates the cardiac fibrosis and hypertrophy in doxorubicin-induced cardiotoxicity rat model. - british journal of pharmacology. 19-20.
muhamad adib abdul ghani, munirah majed alkharji, wan nur izzah shazana wan nawi, ahmad syafi ahmad rushdan, jalifah latip, mohd kaisan mahadi, azizah ugusman, satirah zainalabidin. (2023). carvacrol ameliorates cardiac remodelling in doxorubicin induced-cardiotoxicity rat model. - the 10th federation of the asian and oceanian physiological societies congress (faops 2023). 1.
satirah zainalabidin, nurellya faqhiraah aziz, dharmani devi murugan, mohd kaisan mahadi. (2023). s-allylcysteine limits cardiac remodelling via antioxidative mechanism in estrogen-deficient rats subjected to myocardial injury. - the 10th federation of the asian and oceanian physiological societies congress. 1.
urip harahap, rony abdi syahputra, amer ahmed, azhari nasution, wenny wisely, maureen lazurit sirait, aminah dalimunthe, satirah zainalabidin, nurpudji astuti taslim, fahrul nurkolis, bonglee kim. (2024). current insights and future perspectives of flavonoids: a promising antihypertensive approach. - phytotherapy research. 3146-3168.
nor hidayah mustafa, juriyati jalil, mohammed s. m. saleh, satirah zainalabidin, ahmad yusof asmadi, yusof kamisah. (2023). parkia speciosa hassk. empty pod extract prevents cardiomyocyte hypertrophy by inhibiting mapk and calcineurin-nfatc3 signaling pathways. - life. 1-19.
yusof kamisah, juriyati jalil, nurhanan murni yunos, satirah zainalabidin. (2023). cardioprotective properties of kaempferol: a review. - plants. 1-20.
muhamad adib abdul ghani, munirah majed alkharji, wan nur izzah shazana wan nawi, ahmad syafi ahmad rushdan, jalifah latip, azizah ugusman, mohd kaisan mahadi, satirah zainalabidin. (2023). carvacrol ameliorates the cardiac fibrosis and hypertrophy in doxorubicin-induced cardiotoxicity rat model. - british journal of pharmacology. 19-20.
muhamad adib abdul ghani, azizah ugusman, jalifah latip, satirah zainalabidin. (2023). role of terpenophenolics in modulating inflammation and apoptosis in cardiovascular diseases: a review. - international journal of molecular sciences. 1-22.
syaifuzah sapian, siti balkis budin, izatus shima taib, vanitha mariappan, satirah zainalabidin, kok yong chin. (2022). role of polyphenol in regulating oxidative stress, inflammation, fibrosis, and apoptosis in diabetic nephropathy. - endocrine, metabolic & immune disorders - drug targets. 453-470.
fatin farhana jubaidi, satirah zainalabidin, izatus shima taib, zariyantey abdul hamid, siti balkis budin. (2022). pemodelan semula jantung dalam kardiomiopati diabetes: peranan inflamasi, tekanan oksidatif dan apoptosis yang mendasari pembentukan dan perkembangannya. - sains malaysiana. 4043-4057.
rajasegar anamalley, logeswary rajassageran, yasaaswini apparoo, muhammad haffiz jauri, yusof kamisah, nurhanan murni yunos, satirah zainalabidin. (2022). repeated administration of low dose isoprenaline on the rat's cardiovascular system. - sains malaysiana. 2147-2157.
syed abd halim, s. a., abd ghafar, n., das, s., zainalabidin, s. and jubri, z.. (2021). cardioprotective effects of gynura procumbens extract on oxidative status and myocardial injury in rats with isoproterenol-induced myocardial infarction. - international food research journal. 1223-1232.
shafreena shaukat ali, liza noordin, ruzilawati abu bakar, satirah zainalabidin, zakiah jubri, wan amir nizam wan ahmad. (2021). current updates on potential role of flavonoids in hypoxia/ reoxygenation cardiac injury model. - cardiovascular toxicology. 605-618.
urip harahap, rony abdi syahputra, amer ahmed, azhari nasution, wenny wisely, maureen lazurit sirait, aminah dalimunthe, satirah zainalabidin, nurpudji astuti taslim, fahrul nurkolis, bonglee kim. (2024). current insights and future perspectives of flavonoids: a promising antihypertensive approach. - phytotherapy research. 3146-3168.
satirah zainalabidin, nurellya faqhiraah aziz, dharmani devi murugan, mohd kaisan mahadi. (2023). s-allylcysteine prevents cardiac morphological changes via antioxidative mechanism in estrogen-deficient rats subjected to myocardial injury. - british journal of pharmacology. 66-67.
muhamad adib abdul ghani, munirah majed alkharji, wan nur izzah shazana wan nawi, ahmad syafi ahmad rushdan, jalifah latip, azizah ugusman, mohd kaisan mahadi, satirah zainalabidin. (2023). carvacrol ameliorates the cardiac fibrosis and hypertrophy in doxorubicin-induced cardiotoxicity rat model. - british journal of pharmacology. 19-20.
yusof kamisah, juriyati jalil, nurhanan murni yunos, satirah zainalabidin. (2023). cardioprotective properties of kaempferol: a review. - plants. 1-20.
satirah zainalabidin, nurellya faqhiraah aziz, dharmani devi a/p murugan, mohd kaisan mahadi. (2023). s-allylcysteine limits cardiac structural changes via antioxidant status in ovariectomized rats with induced myocardial injury. - european heart journal. 175.
anand ramalingam, norsyahida mohd. fauzi, siti balkis budin, rebecca ritchie, satirah zainalabidin. (2020). angiotensin ii type i receptor antagonism prevents nicotine-induced cardiac dysfunction in rats. - 23rd world congress of the international-society-for-heart-research (ishr). 8.
muhamad adib abdul ghani, lim yi cheng, siti balkis budin, satirah zainalabidin. (2023). merungkai khasiat rosel dalam bidang kesihatan. - . 17.
shafreena shaukat ali, satirah zainalabidin, kamisah yusof. (2021). kaliks rosel: kaliks di dalam pengawalaturan semula jantung. - . 126.
satirah zainalabidin, farah wahida ibrahim & siti fathiah masre. (2021). nilai terapeutik hasilan semula jadi. - . 4.
satirah zainalabidin, farah wahida ibrahim, siti fathiah masre. (2021). nilai terapeutik hasilan semula jadi. - . 147.
satirah zainalabidin, rumaisak farizal, shafreena shaukat ali & siti balkis budin. (2021). nilai terapeutik hasilan semula jadi. - . 15.
muhamad adib abdul ghani, lim yi cheng, siti balkis budin, satirah zainalabidin. (2023). merungkai khasiat rosel dalam bidang kesihatan. - . 17.
satirah zainalabidin, rumaisak farizal, shafreena shaukat ali & siti balkis budin. (2021). nilai terapeutik hasilan semula jadi. - . 15.
satirah zainalabidin, farah wahida ibrahim & siti fathiah masre. (2021). nilai terapeutik hasilan semula jadi. - . 4.
satirah zainalabidin, siti fathiah masre & farah wahida ibrahim. (2021). nilai terapeutik hasilan semula jadi. - . 6.
shafreena shaukat ali, satirah zainalabidin, kamisah yusof. (2021). kaliks rosel: kaliks di dalam pengawalaturan semula jantung. - . 126.
satirah zainalabidin, farah wahida ibrahim, siti fathiah masre. (2021). nilai terapeutik hasilan semula jadi. - . 147.
mohd kaisan bin mahadi;satirah binti zainalabidin;chua eng wee. (2024). vagus nerve stimulation: investigation on cholinergic anti-inflammatory activity and macrophage polarization in rats with induced myocardial infarction.. - . .
putera muhammad hazim amiruddin, liyana shafiqah sahul hamid, nor syafinaz yaakob, satirah zainalabidin. (2023). the effect of zingiber officinale extract on chronic nicotine toxicity in mice kidney. - 13th malaysian symposium of biomedical science (mysymbios). 1-33.
satirah zainalabidin, nurellya faqhiraah aziz, dharmani devi murugan, mohd kaisan mahadi. (2023). s-allylcysteine limits cardiac remodelling via antioxidative mechanism in estrogen-deficient rats subjected to myocardial injury. - the 10th federation of the asian and oceanian physiological societies congress. 1.
noor yazmin natasha binti hitam, jalifah latip, satirah zainalabidin. (2023). the effect of carvacryl-2-oxoethlygallate on oxidative stress in doxorubicin-induced cardiotoxicity. - 13th malaysian symposium of biomedical science (mysymbios). 1-24.
muhamad adib abdul ghani, munirah majed alkharji, wan nur izzah shazana wan nawi, ahmad syafi ahmad rushdan, jalifah latip, mohd kaisan mahadi, azizah ugusman, satirah zainalabidin. (2023). carvacrol ameliorates cardiac remodelling in doxorubicin induced-cardiotoxicity rat model. - the 10th federation of the asian and oceanian physiological societies congress (faops 2023). 1.
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| THE CARDIOPROTECTIVE POTENTIAL OF S-ALLYL-L-CYSTEINE (SAC) IN MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN OVARIECTOMIZED RATS | labquip (adinstrument malaysia) | 57.1% (2023-10-01 sehingga 2025-09-30) |
| ELUCIDATION OF ANTIHYPERTROPHIC EFFECTS OF PARKIA SPECIOSA HASSK. EXTRACT VIA CALCIUM REGULATION IN CARDIOMYOCYTES EXPOSED TO ANGIOTENSIN II | institut penyelidikan perhutanan malaysia (frim) | 85.7% (2022-10-01 sehingga 2025-03-31) |
| ADAPTATION OF A RESILIENCE-BUILDING INTERVENTION FOR MALAYSIAN YOUNG ADULTS WITH ADVERSE CHILDHOOD EXPERIENCE | resilience research centre | 85.7% (2022-10-01 sehingga 2025-03-31) |
| ADAPTATION OF A RESILIENCE-BUILDING INTERVENTION FOR MALAYSIAN YOUNG ADULTS WITH ADVERSE CHILDHOOD EXPERIENCE | thrive well | 85.7% (2022-10-01 sehingga 2025-03-31) |
| ADAPTATION OF A RESILIENCE-BUILDING INTERVENTION FOR MALAYSIAN YOUNG ADULTS WITH ADVERSE CHILDHOOD EXPERIENCE | dr. michael ungar | 85.7% (2022-10-01 sehingga 2025-03-31) |