pensyarah universiti
pusat kajian toksikologi & risiko kesihatan (core)
satirah@ukm.edu.my
Kluster Kepakaran/ Cluster of Expertise :
Kesihatan dan Perubatan Termaju,
Biografi/ Biography :
Saya telah menjalani pengkhususan di dalam bidang fisiologi dan farmakologi kardiovaskular, dengan penumpuan ke atas mekanisme kecederaan kardiovaskular dan potensi intervensi terapeutik. Penyelidikan kami menggunakan pelbagai jenis model haiwan, termasuk kecederaan jantung yang disebabkan oleh isoprenalin dan nikotin, untuk menyelidiki laluan yang terlibat dalam kerosakan jantung. Salah satu bidang minat utama saya ialah potensi terapeutik tumbuhan perubatan dan sebatian bioaktif. Kajian kami telah meneroka kesan ekstrak kaya antosianin daripada roselle (Hibiscus sabdariffa), glikosida kardio 17β-neriifolin daripada Cerbera odollum, dan S-allylcysteine daripada bawang putih, dengan tujuan untuk mengenal pasti sifat kardioprotektif dan mekanisme tindakannya. Penyelidikan ini telah menyumbang kepada pemahaman dan bukti bahawa penggunaan sebatian semula jadi mempunyai potensi di dalam terapi kardiovaskular. Di dalam makmal, kami mempelopori pelbagai teknik, terutamanya sistem perfusi jantung terasing menggunakan alat Langendorff—satu teknik yang satu-satunya aktif di dalam bidang penyelidikan kardiovaskular di Malaysia. Selain itu, kami juga mengkaji kereaktifan vaskular, tapak jalan protein, dan ekspresi gen untuk lebih memahami fungsi dan penyakit kardiovaskular.
I specialize in cardiovascular physiology and pharmacology, with a strong focus on unravelling the mechanisms of cardiovascular injury and exploring potential therapeutic interventions. Our research involves utilizing animal models, such as isoprenaline-induced and nicotine-induced cardiac injury, to gain insights into the intricate pathways of heart damage. An area of particular interest is the therapeutic potential of medicinal plants and bioactive compounds. Our work has explored the effects of anthocyanin-rich extracts from roselle (Hibiscus sabdariffa), the cardiac glycoside 17β-neriifolin from Cerbera odollum, and S-allylcysteine, a sulfur-containing compound derived from garlic. These studies aim to uncover their cardioprotective properties and mechanisms of action. I am proficient in advanced laboratory techniques, with a primary focus on the isolated perfused heart system using the Langendorff apparatus—a technique that stands out as the only active cardiovascular research approach in Malaysia. Additionally, I am involved in research on vascular reactivity and investigating protein and gene expression pathways to deepen our understanding of cardiovascular regulation and potential drug targets.
rini retnosari, muhamad adib abdul ghani, munirah majed alkharji, wan nur izzah shazana wan nawi, ahmad syafi ahmad rushdan, mohd kaisan mahadi, azizah ugusman, natsuhisa oka, satirah zainalabidin, jalifah latip. (2025). the protective effects of carvacrol against doxorubicin-induced cardiotoxicity in vitro and in vivo. - cardiovascular toxicology. 167 - 181.
jun kiat, mahadir ahmad, caryn mei hsien chan, satirah zainalabidin, michael ungar, ponnusamy subramaniam. (2025). effectiveness of adaptation of a resilience-building intervention among individuals with adverse childhood experience: protocol for a randomized controlled trial. - jmir research protocols. 150 - 164.
nurellya faqhiraah aziz, satirah zainalabidin, mohd kaisan mahadi, dharmani devi murugan. (2025). sebatian bawang putih: khas untuk kesihatan jantung wanita. - . .
poh ya hui, haziq zul azfar hisham, mohamad luqman nur iman mohamad zain, satirah zainalabidin. (2025). the effect of roselle extract-loaded chitosan nanoparticle to the liver and kidneys in streptozotocin-induced diabetes rat. - international postgraduate colloquium in health and pharmacy (inchap) 2025. .
syaifuzah sapian, siti balkis budin, izatus shima taib, satirah zainalabidin, jalifah latip, haliza katas. (2025). roselle extract–loaded chitosan nanoparticles attenuate cardiac dysfunction and oxidative stress in diabetic rats. - international postgraduate colloquium in health and pharmacy (inchap) 2025. .
rini retnosari, muhamad adib abdul ghani, munirah majed alkharji, wan nur izzah shazana wan nawi, ahmad syafi ahmad rushdan, mohd kaisan mahadi, azizah ugusman, natsuhisa oka, satirah zainalabidin, jalifah latip. (2025). the protective effects of carvacrol against doxorubicin-induced cardiotoxicity in vitro and in vivo. - cardiovascular toxicology. 167 - 181.
rajasegar anamalley, yusof kamisah, nurhanan murni yunos, satirah zainalabidin. (2025). 17ßh-neriifolin improves cardiac remodeling through modulation of calcium handling proteins in the heart failure rat model. - biomedicines. 1 - 16.
urip harahap, rony abdi syahputra, amer ahmed, azhari nasution, wenny wisely, maureen lazurit sirait, aminah dalimunthe, satirah zainalabidin, nurpudji astuti taslim, fahrul nurkolis, bonglee kim. (2024). current insights and future perspectives of flavonoids: a promising antihypertensive approach. - phytotherapy research. 3146-3168.
rini retnosari, kentaro oh-hashi, azizah ugusman, satirah zainalabidin, jalifah latip, natsuhisa oka. (2024). carvacrol-conjugated 3-hydroxybenzoic acids: design, synthesis, cardioprotective potential against doxorubicin-induced cardiotoxicity, and admet study. - bioorganic & medicinal chemistry letters. 1 - 9.
abdi syahputra, rony; dalimunthe, aminah; utari, zahirah dyiah; halim, princella; sukarno, muhammad andriansyah; zainalabidin, satirah; salim, emil; gunawan, maxius; nurkolis, fahrul; park, moon nyeo; luckanagul, jittima amie; bangun, hakim; kim, bonglee; harahap, urip. (2024). nanotechnology and flavonoids: current research and future perspectives on cardiovascular health. - journal of functional foods. 1 - 19.
jie lee, muhamad adib abdul ghani, satirah zainalabidin. (2025). effects of s-allyl cysteine on vascular reactivity in ovariectomized rats. - revista brasileira de farmacognosia. 486 - 490.
chee hooi chung, mohammad yusuf hasan, satirah zainalabidin, chua eng wee, azizah ugusman, zakiah jubri, mohd kaisan mahadi. (2025). modulation of a7nachr for cardioprotection against isoprenaline-induced myocardial injury. - sains malaysiana. 3727 - 3740.
fatin farhana jubaidi, nur liyana mohammed yusof, satirah zainalabidin, izatus shima taib, zariyantey abd hamid & siti balkis budin. (2024). determining the time points for the development of early and advanced stages of diabetic cardiomyopathy in streptozotocin-induced type 1 diabetes mellitus rat model . - sains malaysiana. 1321 - 1332.
fatin farhana jubaidi, satirah zainalabidin, izatus shima taib, zariyantey abdul hamid, siti balkis budin. (2022). pemodelan semula jantung dalam kardiomiopati diabetes: peranan inflamasi, tekanan oksidatif dan apoptosis yang mendasari pembentukan dan perkembangannya. - sains malaysiana. 4043-4057.
syaifuzah sapian, siti balkis budin, izatus shima taib, vanitha mariappan, satirah zainalabidin, kok yong chin. (2022). role of polyphenol in regulating oxidative stress, inflammation, fibrosis, and apoptosis in diabetic nephropathy. - endocrine, metabolic & immune disorders - drug targets. 453-470.
jie lee, muhamad adib abdul ghani, satirah zainalabidin. (2025). effects of s-allyl cysteine on vascular reactivity in ovariectomized rats. - revista brasileira de farmacognosia. 486 - 490.
rony abdi syahputra, helen helen, mega carensia gunawan, zahirah dhiya utari, aminah dalimunthe, emil salim, marianne bastian, nurpudji astuti taslim, pipit pitriani, sony eka nugraha, putri cahaya situmorang, fahrul nurkolis, satirah zainalabidin. (2025). eriobotrya japonica a review: phytochemical constituents, traditional uses, and therapeutic potentials. - journal of agriculture and food research. 1 - 21.
rini retnosari, muhamad adib abdul ghani, munirah majed alkharji, wan nur izzah shazana wan nawi, ahmad syafi ahmad rushdan, mohd kaisan mahadi, azizah ugusman, natsuhisa oka, satirah zainalabidin, jalifah latip. (2025). the protective effects of carvacrol against doxorubicin-induced cardiotoxicity in vitro and in vivo. - cardiovascular toxicology. 167 - 181.
chee hooi chung, mohammad yusuf hasan, satirah zainalabidin, chua eng wee, azizah ugusman, zakiah jubri, mohd kaisan mahadi. (2025). modulation of a7nachr for cardioprotection against isoprenaline-induced myocardial injury. - sains malaysiana. 3727 - 3740.
jun kiat, mahadir ahmad, caryn mei hsien chan, satirah zainalabidin, michael ungar, ponnusamy subramaniam. (2025). effectiveness of adaptation of a resilience-building intervention among individuals with adverse childhood experience: protocol for a randomized controlled trial. - jmir research protocols. 150 - 164.
anand ramalingam, norsyahida mohd. fauzi, siti balkis budin, rebecca ritchie, satirah zainalabidin. (2020). angiotensin ii type i receptor antagonism prevents nicotine-induced cardiac dysfunction in rats. - 23rd world congress of the international-society-for-heart-research (ishr). 8.
yanti rosli, asmah hamid, mazlyzam abdul latif, nur najmi mohamad anuar, satirah zainal abidin, siti fathiah masre. (2025). covid-19: faktor risiko status kesihatan. - . 53 - 84.
muhamad adib abdul ghani, lim yi cheng, siti balkis budin, satirah zainalabidin. (2023). potensi rosel ke atas sistem kardiovaskular. - . 77-93.
satirah zainalabidin, rumaisak farizal, shafreena shaukat ali & siti balkis budin. (2021). kesan ekstrak akueus rosel terhadap sistem kardiovaskular. - . 22-37.
satirah zainalabidin, farah wahida ibrahim & siti fathiah masre. (2021). nilai terapeutik hasilan semula jadi tahap praklinikal. - . 17-21.
satirah zainalabidin, siti fathiah masre & farah wahida ibrahim. (2021). prospek hasilan semula jadi di dalam perubatan klinikal. - . 107-112.
satirah zainalabidin, fatin farhana jubaidi. (2025). dari ukm ke louisville: perkongsian alumni sains bioperubatan sebagai felo pasca doktoral di luar negara. - buletin alumni fakulti sains kesihatan, ukm. .
yanti rosli, asmah hamid, mazlyzam abdul latif, nur najmi mohamad anuar, satirah zainal abidin, siti fathiah masre. (2025). covid-19: faktor risiko status kesihatan. - . 53 - 84.
nurellya faqhiraah aziz, satirah zainalabidin, mohd kaisan mahadi, dharmani devi murugan. (2025). sebatian bawang putih: khas untuk kesihatan jantung wanita. - . .
muhamad adib abdul ghani, lim yi cheng, siti balkis budin, satirah zainalabidin. (2023). potensi rosel ke atas sistem kardiovaskular. - . 77-93.
yap wei boon;satirah binti zainalabidin. (2022). development and mechanism of action of np-ha2-m2e influenza universal vaccine in promoting humoral and cell-mediated immunity.. - . .
aiman zakwan azman, muhamad adib abdul ghani, satirah zainalabidin. (2025). effect of s-allyl-l-cysteine on oxidative stress and antioxidant status in myocardial ischemia–reperfusion injury of the heart in ovariectomized rats. - 15th malaysian national symposium biomedical sciences. .
poh ya hui, haziq zul azfar hisham, mohamad luqman nur iman mohamad zain, satirah zainalabidin. (2025). the effect of roselle extract-loaded chitosan nanoparticle to the liver and kidneys in streptozotocin-induced diabetes rat. - international postgraduate colloquium in health and pharmacy (inchap) 2025. .
syaifuzah sapian, siti balkis budin, izatus shima taib, satirah zainalabidin, jalifah latip, haliza katas. (2025). roselle extract–loaded chitosan nanoparticles attenuate cardiac dysfunction and oxidative stress in diabetic rats. - international postgraduate colloquium in health and pharmacy (inchap) 2025. .
muhamad adib abdul ghani, izatus shima taib, mohd kaisan mahadi, norliza muhammad, satirah zainalabidin. (2025). effects of s-allyl-l-cysteine on myocardial infarction via the nrf2 pathway in an ovariectomized rat model. - international postgraduate colloquium in health and pharmacy (inchap) 2025. .
chai yi ping, muhamad adib abdul ghani, izatus shima taib, mohd kaisan mahadi, norliza muhamad, satirah zainalabidin. (2025). the effects of s-allyl cysteine to kidney injury induced by myocardial ischemia reperfusion in ovarietomized rats. - 15th malaysian national symposium biomedical sciences. .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| THE CARDIOPROTECTIVE POTENTIAL OF S-ALLYL-L-CYSTEINE (SAC) IN MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN OVARIECTOMIZED RATS | labquip (adinstrument malaysia) | 79.5% (2023-10-01 sehingga 2026-06-30) |
| EFFECTS OF GUNDELIA TOURNEFORTII L. ON CALCINEURIN–NFAT–GATA4 PATHWAY IN ANGIOTENSIN II-INDUCED HYPERTROPHIED CARDIOMYOCYTES IN VITRO | university of jordan | 34.2% (2025-04-01 sehingga 2027-03-31) |
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Physiology, Pharmacology
Pengalaman / Experience : 10 tahun/years(s)
BIOLOGY :PURE AND APPLIED SCIENCES
Animal study
Pengalaman / Experience : tahun/years(s)
PHARMACOLOGY :CLINICAL AND HEALTH SCIENCES
Physiology Cardiovascular
Pengalaman / Experience : tahun/years(s)