Biografi/ Biography :
Dr Hanafi is an Associate Professor at Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia. He graduated from Universiti Kebangsaan Malaysia with Bachelor of Biomedical Sciences (Hons.) in 2006 before pursuing his postgraduate study at Macquarie University, Sydney Australia and graduated with PhD in Molecular Neuroscience in 2012. Dr Hanafi was the recipient of IBRO/APRC Research Exchange Fellowship Award for 2015 where he went to Brain Mind Research Institute (BMRI), University of Sydney, Australia for his fellowship training. Dr Hanafi has a lot of interest in understanding how ageing affects the brain signalling and the molecular changes associated with brain ageing. He is currently investigating the molecular changes in the brain regions associated with cognitive functions by using state-of-the-art omics approaches. He is also working on a project that is looking at the effect of palm oil tocotrienol supplementation on the cognitive functions of transgenic Alzheimer’s disease (AD) mouse model. Apart from that, he is also interested to understand the effect of ageing in controlling feeding response. He has published many papers in peer-reviewed international journals including Journal of Alzheimer’s Disease, Oxidative Medicine and Cellular Longevity (OMCL), Experimental Gerontology and PLoS One. He is currently the Associate Editor of the Journal of Alzheimer’s Disease. He has several research grants and is currently involved in many research projects and supervision of undergraduate medical students and postgraduate students in UKM.
elvira yunita, muhammad luqman nasaruddin, nur zuliani ramli, mohamad fairuz yahaya, hanafi ahmad damanhuri. (2025). the biochemical signaling pathway affected by the tocotrienol-rich fraction in brain cells. - international conference on advances in medical science . .
elvira yunita, muhammad luqman nasaruddin, nur zuliani ramli, mohamad fairuz yahaya, hanafi ahmad damanhuri . (2025). scoping review: the role of tocotrienol-rich fraction as a potent neuroprotective agent. - international journal of molecular sciences . 1 - 16.
amirul hafiz ahmad abdullah, nurul farhana jufri, siti fathiah masre, nor fadilah rajab, hanafi ahmad damanhuri, nur aishah che roos & farah wahida ibrahim. (2025). harnessing animal studies to uncover pyroptosis mechanisms in alzheimer’s disease: a systematic review protocol. - advances in human biology. 310 - 314.
amirul hafiz ahmad abdullah, nurul farhana jufri, siti fathiah masre, nor fadilah rajab, hanafi ahmad damanhuri, nur aishah che roos and farah wahida ibrahim. (2024). bdnf-altering cell death mechanisms of brain disorders: pyroptosis and/or ferroptosis? a systematic review. - turkish journal of biochemistry. 471 - 483.
nur zuliani ramli, mohamad fairuz yahaya, nur azlina mohd fahami, hamizah shahirah hamezah, zulzikry hafiz abu bakar, aslina pahrudin arrozi, daijiro yanagisawa, ikuo tooyama, meharvan singh, hanafi ahmad damanhuri. (2024). spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake . - experimental gerontology. 1 - 15.
elvira yunita, muhammad luqman nasaruddin, nur zuliani ramli, mohamad fairuz yahaya, hanafi ahmad damanhuri . (2025). scoping review: the role of tocotrienol-rich fraction as a potent neuroprotective agent. - international journal of molecular sciences . 1 - 16.
kah hui yap, shahrul azmin, hanani abdul manan, noorazrul yahya, norfazilah ahmad, farah waheeda tajurudin, siti hajar mat desa, bart van de warrenburg, shahizon azura mohamed mukari, hamdi najman achok, hanafi ahmad damanhuri, rufaidah rani, norlinah mohamed ibrahim. (2024). randomized double-blind placebo-controlled trial of the effects of oral trehalose in spinocerebellar ataxia type 3: an interim analysis. - parkinsonism and related disorders. 1 - 5.
nur zuliani ramli, mohamad fairuz yahaya, nur azlina mohd fahami, hamizah shahirah hamezah, zulzikry hafiz abu bakar, aslina pahrudin arrozi, daijiro yanagisawa, ikuo tooyama, meharvan singh, hanafi ahmad damanhuri. (2024). spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake . - experimental gerontology. 1 - 15.
mohd khairulanwar bunaim, hanafi ahmad damanhuri, hui-yin yow, nor syafinaz yaakob, mohd makmor-bakry, norazrina azmi. (2024). understanding methiopropamine, a new psychoactive substance: an in-depth review on its chemistry, pharmacology and implications to human health. - international journal of legal medicine. 1-12.
kah hui yap, shahrul azmin, suzana makpol, hanafi ahmad damanhuri, muzaimi mustapha, jemaima che hamzah, norlinah mohamed ibrahim. (2023). profiling neuroprotective potential of trehalose in animal models of neurodegenerative diseases: a systematic review. - neural regeneration research. 1179-1185.
amirul hafiz ahmad abdullah, nurul farhana jufri, siti fathiah masre, nor fadilah rajab, hanafi ahmad damanhuri, nur aishah che roos and farah wahida ibrahim. (2024). bdnf-altering cell death mechanisms of brain disorders: pyroptosis and/or ferroptosis? a systematic review. - turkish journal of biochemistry. 471 - 483.
jen kit tan, sakinah husna abdul razak, nazirah ab rani, nur haleeda hakimi, hanafi ahmad damanhuri, suzana makpol & wan zurinah wan ngah. (2022). effects of age and tocotrienol-rich fraction on mitochondrial respiratory complexes in the hippocampus of rats. - sains malaysiana. 249-259.
hanafi ahmad damanhuri, peter robert dunkley & ann kathleen goodchild. (2021). the effects of acute glucoprivation on adrenomedullary function in shr and wky rats. - sains malaysiana. 481-492.
nurul ain mohamad kamal, jiann lin loo, jo aan goon, hanafi ahmad damanhuri, shalisah sharip, suriati mohd saini, jemaima che hamzah, lai fong chan. (2019). oxidative stress: biomarkers in bipolar disorder with suicidal behavior: a systematic review. - journal of pharmaceutical negative results. 6-15.
jaclyn tan ai chin, geetha gunasekaran, mohd hanafi ahmad damanhuri, chan lai fong, loo jiann lin, goon jo aan. (2019). oxidative status in bipolar disorder (bd) and its correlation with age, gender and body masss index (bmi). - sains malaysiana. 1083-1095.
elvira yunita, muhammad luqman nasaruddin, nur zuliani ramli, mohamad fairuz yahaya, hanafi ahmad damanhuri . (2025). scoping review: the role of tocotrienol-rich fraction as a potent neuroprotective agent. - international journal of molecular sciences . 1 - 16.
kah hui yap, shahrul azmin, hanani abdul manan, noorazrul yahya, norfazilah ahmad, farah waheeda tajurudin, siti hajar mat desa, bart van de warrenburg, shahizon azura mohamed mukari, hamdi najman achok, hanafi ahmad damanhuri, rufaidah rani, norlinah mohamed ibrahim. (2024). randomized double-blind placebo-controlled trial of the effects of oral trehalose in spinocerebellar ataxia type 3: an interim analysis. - parkinsonism and related disorders. 1 - 5.
nur zuliani ramli, mohamad fairuz yahaya, nur azlina mohd fahami, hamizah shahirah hamezah, zulzikry hafiz abu bakar, aslina pahrudin arrozi, daijiro yanagisawa, ikuo tooyama, meharvan singh, hanafi ahmad damanhuri. (2024). spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake . - experimental gerontology. 1 - 15.
amirul hafiz ahmad abdullah, nurul farhana jufri, siti fathiah masre, nor fadilah rajab, hanafi ahmad damanhuri, nur aishah che roos and farah wahida ibrahim. (2024). bdnf-altering cell death mechanisms of brain disorders: pyroptosis and/or ferroptosis? a systematic review. - turkish journal of biochemistry. 471 - 483.
mohd khairulanwar bunaim, hanafi ahmad damanhuri, hui-yin yow, nor syafinaz yaakob, mohd makmor-bakry, norazrina azmi. (2024). understanding methiopropamine, a new psychoactive substance: an in-depth review on its chemistry, pharmacology and implications to human health. - international journal of legal medicine. 1-12.
goon jo aan, zakiah jubri, mohd hanafi ahmad damanhuri, wan nurzulaikha wan nasri. (2022). prinsip dan kaedah pengukuran vitamin antioksidan menggunakan high performance liquid chromatography (hplc). - . 100-114.
ikuo tooyama, nor faeizah ibrahim, lina wati durani, hamizah shahirah hamezah, mohd hanafi ahmad damanhuri, wan zurinah wan ngah, hiroyasu taguchi and daijiro yanagisawa. (2016). curcumin against amyloid pathology in mental health and brain composition. - . 487-508.
ekram bin alias;norazlina binti mohamed;nor hamdan bin mohamad yahaya;mohd hanafi bin ahmad damanhuri;ng min hwei;tan jen kit;wan zurinah wan ngah (prof. dr.). (2023). study on cellular energy metabolism and mitochondrial respiration of osteoclasts induced by polyethylene for the development of pet-ct diagnostic application for peri-prosthetic osteolysis. - . .
goon jo aan, zakiah jubri, mohd hanafi ahmad damanhuri, wan nurzulaikha wan nasri. (2022). prinsip dan kaedah pengukuran vitamin antioksidan menggunakan high performance liquid chromatography (hplc). - . 100-114.
tan jen kit;suzana binti makpol;mohd hanafi bin ahmad damanhuri;wan zurinah wan ngah (prof. dr.). (2021). investigating the role of mitochondria function on age-associated adult hippocampal neurogenesis deficit and its modulation by gamma-tocotrienol. - . .
ahmad rohi ghazali, anisah nordin, asmah hamid, kamisah yusof, khairul osman, low kiat cheong, mohd hanafi ahmad damanhuri, norazrina azmi, nur azlina mohd fahami, siti balkis budin, siti fatimah ibrahim, tay sun tee, zamirah zainal abidin. (2020). prinsip dan garis panduan etika penggunaan haiwan makmal universiti kebangsaan malaysia. - . 94.
wan zurinah wan ngah, suzana makpol, yasmin anum mohd yusof, zakiah jubri, nor wahidah abdul karim, goon jo aan, mohd hanafi ahmad damanhuri, . noor akmal shareela ismail, khaizurin tajul arifin, ekram alias. (2015). laporan penambahbaikan kursus biokimia untuk program sarjana sains perubatan secara kerja kursus (biokimia). - . 1-4.
elvira yunita, muhammad luqman nasaruddin, nur zuliani ramli, mohamad fairuz yahaya, hanafi ahmad damanhuri. (2025). the biochemical signaling pathway affected by the tocotrienol-rich fraction in brain cells. - international conference on advances in medical science . .
norlinah binti mohamed ibrahim;shahrul azmin bin md. rani;norfazilah binti ahmad;mohd hanafi bin ahmad damanhuri;noorazrul azmie bin yahya;hanani binti abdul manan. (2024). clinical efficacy of oral trehalose in spinocerebellar ataxia 3: correlation with fmri findings . - . .
amirul hafiz ahmad abdullah, nurul farhana jufri, siti fathiah masre, nor fadilah rajab, hanafi ahmad damanhuri , noor aishah che roos, farah wahida ibrahim. (2024). the role of pyroptosis in alzheimer’s disease progression: a systematic review of animal studies. - 14th international symposium of health sciences . .
hamizah shahirah hamezah, yu jing, ping liu, hu zhang, wan zurinah wan ngah, mohd hanafi ahmad damanhuri, musalmah mazlan. (2024). modulation of arginine metabolism in aging brain by palm oil tocotrienol-rich fraction. - international symposium on synthetic biology and crispr technology (isynbioct 2024). .
hamizah shahirah hamezah, lina wati durani, nor faeizah ibrahim, daijiro yanagisawa, hanafi ahmad damanhuri, wan zurinah wan ngah, ikuo tooyama. (2024). proteome profiles in transgenic alzheimer’s disease mice brain and modulation by vitamin e tocotrienol-rich fraction. - biomedical chemistry: science and practice conference. .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| TOCOTRIENOL AS A SENOLYTIC AGENT: A PHASE 2 CLINICAL TRIAL | malaysian palm oil board | 66.1% (2022-11-29 sehingga 2027-01-30) |
| TOCOTRIENOL AS A SENOLYTIC AGENT: A PHASE 2 CLINICAL TRIAL | davos life science sdn bhd | 66.1% (2022-11-29 sehingga 2027-01-30) |
| KESAN KETAGIHAN DAN KETOKSIKAN BAHAN PSIKOAKTIF BAHARU (NPS) TERPILIH | jabatan siasatan jenayah narkotik, polis diraja malaysia | 57.9% (2023-11-01 sehingga 2026-12-31) |