prof. madya dr. nurul syakima binti ab mutalib

pensyarah universiti

institut biologi molekul perubatan ukm (umbi)

 syakima@ukm.edu.my



   Kluster Kepakaran/ Cluster of Expertise :
  • Kesihatan dan Perubatan Termaju,



  •    Biografi/ Biography :


  • I am a scientist and academician in medical molecular biology. I`ve been fortunate to contribute to cancer research, molecular diagnostics, and epigenetics over the years. My focus on molecular medicine and noncoding RNA has allowed me to play a part in Malaysia`s scientific community. My research on circulating tumor cells and single-cell transcriptomics of colorectal cancer has been recognized by my peers, which I consider a great honor. I`ve held leadership positions, including team leader in cancer genomics and biobanking, Chief Technical Officer, and Head of Quality Assurance. I`ve had the opportunity to collaborate with institutions worldwide, including a fellowship at the Institute of Genomic Medicine at Newcastle University, England. I was awarded several grants and awards from organizations such as Qiagen, Korean Cancer Association and the Hong Kong Institute of Digestive Disease. I`ve held various positions, including Application Scientist at Science Vision Sdn Bhd, Visiting Fellow at Newcastle University, Associate Fellow at the Faculty of Health Sciences, UKM, and Adjunct Senior Lecturer at Monash University.

  • nima rezaei.  (2025).  molecular markers in circulating tumour cells: advancing clinical precision.  - interdisciplinary cancer research.  513 - 540. 

     

    khairunnisa mohd kamal, ahmad rohi ghazali, gayathri thevi selvarajah, nurul syakima ab mutalib, nadiah abu, eng wee chua, siti fathiah masre.  (2025).  histopathological evaluation of a dna methyltransferase inhibitor in an ntcu-induced dual-stage lung carcinogenesis mouse model.  - american association for cancer research on campus. 

     

    nur fadhlina mohamad pakarulrazy, nadiah abu, shahrun niza abdullah suhaimi, nadzlee harith paisol, reena rahayu md zin, nani h. mdlatar, nurul syakima ab mutalib.  (2025).  gene expression analysis of papillary thyroid carcinoma with lymph node metastasis and radioiodine refractivity.  - cureus.  1 - 22. 

     

    khairunnisa mohd kamal, ahmad rohi ghazali, gayathri thevi selvarajah, nurul syakima ab mutalib, nadiah abu, eng wee chua, siti fathiah masre.  (2025).  freezing tissues pre-homogenisation reduces degradation and yields improved quality rna in the mouse lung.  - biochemistry and biophysics reports.  1 - 4. 

     

    lim c.l, ab mutalib n.s., masre s.f., azmi f.b., nik eezamuddeen m., abdul murad n.a. abu n..  (2025).  extracellular vesicle profiling reveals immunomodulatory changes in colorectal cancer: implications for early diagnosis and chemotherapy response.  - 18th annual meeting of the korean society of medical oncology & 2025 international conference (ksmo 2025). 

     

    francis yew fu tieng, learn-han lee & nurul-syakima ab mutalib .  (2025).  single-cell rna-sequencing of circulating tumour cells: a practical guide to workflow and translational applications.  - cancer and metastasis reviews.  1 - 46. 

     

    francis yew fu tieng, muhammad-redha abdullah-zawawi, nur alyaa afifah md shahri, zeti-azura mohamed-hussein, learn-han lee, nurul-syakima ab mutalib.  (2024).  a hitchhiker’s guide to rna–rna structure and interaction prediction tools.  - briefings in bioinformatics.  1 - 37. 

     

    nur farhana mohd nippah, nadiah abu, nurul syakima ab mutalib, hamidah alias.  (2024).  advances in next-generation sequencing for relapsed pediatric acute lymphoblastic leukemia: current insights and future directions.  - frontiers in genetics.  1 - 9. 

     

    khairunnisa mohd kamal, ahmad rohi ghazali, nurul syakima ab mutalib, nadiah abu, eng wee chua siti fathiah masre.  (2024).  the role of dna methylation and dna methyltransferases (dnmts) as potential biomarker and therapeutic target in non-small cell lung cancer (nsclc).  - heliyon.  1 - 17. 

     

    francis yew fu tieng, muhammad-redha abdullah-zawawi, nur alyaa afifah md shahri, zeti-azura mohamed-hussein, learn-han lee, nurul-syakima ab mutalib.  (2024).  a hitchhiker's guide to rna-rna structure and interaction prediction tools.  - briefings in bioinformatics.  1-37. 

     

    habsah aziz, nurul syakima ab mutalib, hamidah alias, rahman jamal.  (2024).  whole genome sequencing reveals the mutational landscape from disease diagnosis to relapse in patients with childhood acute myeloid leukaemia.  - malaysian journal of pathology.  259 - 278. 

     

    nadiah abu, nurul ainaa adilah rus bakarurraini, siti nurmi nasir, muhiddin ishak, rashidah baharuddin, rahman jamal, nurul syakima ab mutalib.  (2023).  methylation profile of cancer testis antigens in colorectal cancer.  - iranian journal of immunology.  83-91. 

     

    nor azila ma, nor azian am, azmawati mn, sharifah azura s, petrick p, najma k, mohd rohaizat h, norfazilah a, anita s, hanita o, tuti ningseh md, nurul syakima am, ezanee azlina, siti aishah, nurul syeefa', abdul rashid, abdul halim, hanafiah hr, rahman j.  (2021).  covid-19 in malaysia: exposure assessment and prevention practices among healthcare workers at a teaching hospital.  - journal of infection in developing countries.  1816-1824. 

     

    nur fadhlina mohamad pakarulrazy, saiful effendi syafruddin, nurul syakima ab mutalib, azlina ahmad annuar, shen yang lim, rahman jamal, nor azian abdul murad, norlinah mohamed ibrahim.  (2020).  glucocerebrosidase genetic variants in malays with early and late-onset parkinson's disease.  - neurology asia.  39-46. 

     

    siti a sulaiman, nadiah abu, nurul-syakima ab mutalib, teck yew low, rahman jamal.  (2019).  signatures of gene expression, dna methylation and micrornas of hepatocellular carcinoma with vascular invasion.  - future oncology.  2603-2617. 

     

    khairunnisa mohd kamal, ahmad rohi ghazali, gayathri thevi selvarajah, nurul syakima ab mutalib, nadiah abu, eng wee chua, siti fathiah masre.  (2025).  freezing tissues pre-homogenisation reduces degradation and yields improved quality rna in the mouse lung.  - biochemistry and biophysics reports.  1 - 4. 

     

    nur fadhlina mohamad pakarulrazy, nadiah abu, shahrun niza abdullah suhaimi, nadzlee harith paisol, reena rahayu md zin, nani h. mdlatar, nurul syakima ab mutalib.  (2025).  gene expression analysis of papillary thyroid carcinoma with lymph node metastasis and radioiodine refractivity.  - cureus.  1 - 22. 

     

    francis yew fu tieng, learn-han lee & nurul-syakima ab mutalib .  (2025).  single-cell rna-sequencing of circulating tumour cells: a practical guide to workflow and translational applications.  - cancer and metastasis reviews.  1 - 46. 

     

    muhammad-redha abdullah-zawawi, muhammad irfan abdul jalal, shing cheng tan, loscheni varma, nur alyaa afifah md shahri, mira farzana mohamad mokhtar, ryia illani mohd yunos, nurul syakima ab mutalib, rahman jamal.  (2025).  bioinformatics-driven identification of key non-invasive prognostic biomarkers in hepatocellular carcinoma.  - egyptian journal of medical human genetics.  1 - 16. 

     

    francis yew fu tieng, muhammad-redha abdullah-zawawi, nur alyaa afifah md shahri, zeti-azura mohamed-hussein, learn-han lee, nurul-syakima ab mutalib.  (2024).  a hitchhiker’s guide to rna–rna structure and interaction prediction tools.  - briefings in bioinformatics.  1 - 37. 

     

    lina rozano, muhammad irfan abdul jalal, nur alyaa afifah md shahri, zeti-azura mohamed-hussein, nurul syakima ab mutalib, muhammad-redha abdullah-zawawi.  (2025).  molecular fingerprints and pharmacophores for computational drug repurposing.  - 746 - 756. 

     

    nima rezaei.  (2025).  molecular markers in circulating tumour cells: advancing clinical precision.  - interdisciplinary cancer research.  513 - 540. 

     

    muhammad-redha abdullah-zawawi, seow neng chan, francis yew fu tieng, zeti-azura mohamed-hussein, and nurul-syakima ab mutalib.  (2025).  drug repositioning using single-cell rna sequencing in cancer research.  - 635 - 666. 

     

    siti aishah sulaiman, muhammad nafiz haidi adrus, vicneswarry dorairaj, nadiah abu, nurul syakima ab mutalib, khairul najmi muhammad nawawi, nor azian abdul murad.  (2024).  4.11 - stem cells and extracellular vesicles for prevention and treatment of liver fibrosis.  - reference work.  146 - 158. 

     

    saiful effendi syafruddin, mohamad aimanuddin mohtar, tan shing cheng, nadiah abu, nor aidatulakma abdullah@muda, nurul syakima ab mutalib, chin siok fong, neoh hui min, rahman jamal, nor azian abdul murad.  (2019).  umbi initiatives on colorectal cancer biomarkers discovery.  - 19-28. 

     

    habsah aziz, rahman jamal, nurul syakima ab mutalib.  (2024).  kanser darah putih: kod rahsia jujukan dna kanak kanak .  -

     

    francis yew fu tieng, nurul syakima ab mutalib.  (2022).  transkriptom sel tunggal dalam kanser kolorektal - aplikasi dalam metastasis, rintangan terhadap rawatan kemoterapi dan peranan sel tumor beredar.  - 1-2. 

     

    nurul syakima ab mutalib, tan shing cheng, siti aishah sulaiman, rahman jamal.  (2020).  adakah anda mewarisi gen untuk risiko serangan jantung?.  - 1. 

     

    muhiddin ishak, nadiah abu, nurul syakima ab mutalib.  (2020).  metilasi dna : pengaruh dalam kanser.  - 117. 

     

    azliana mohamad yusof, nurul syakima ab mutalib.  (2020).  teknologi mikrorna: aplikasi dalam rawatan kanser.  - 137. 

     

    nurul syakima ab mutalib.  (2025).  polymorphic microbiomes in cancer (for invited lecture um x curie masterclass of cancer molecular biology).  -

     

    khairunnisa mohd kamal, ahmad rohi ghazali, gayathri thevi selvarajah, nurul syakima ab mutalib, nadiah abu, eng wee chua, siti fathiah masre.  (2025).  histopathological evaluation of a dna methyltransferase inhibitor in an ntcu-induced dual-stage lung carcinogenesis mouse model.  - american association for cancer research on campus. 

     

    nur fadhlina mohamad pakarulrazy, nadiah abu, nani md latar and nurul-syakima ab mutalib.  (2025).  abcb4 silencing impairs thyroid differentiation and iodide uptake in papillary thyroid carcinoma.  - asian regional conference on systems biology (arcsb2025) x international conference on natural products (icnp2025). 

     

    nurul-syakima ab mutalib.  (2025).  leveraging ai in bioinformatics: developing crc-mirnamethylomic for rapid microrna methylation analysis, visualization, and integrated gene annotation in colorectal cancer.  - asian regional conference on systems biology (arcsb2025) x international conference on natural products (icnp2025). 

     

    lim c.l, ab mutalib n.s., masre s.f., azmi f.b., nik eezamuddeen m., abdul murad n.a. abu n..  (2025).  extracellular vesicle profiling reveals immunomodulatory changes in colorectal cancer: implications for early diagnosis and chemotherapy response.  - 18th annual meeting of the korean society of medical oncology & 2025 international conference (ksmo 2025). 

     

    BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
    Molecular Biology, Noncoding RNA, Epigenetics, DNA methylation, MicroRNAs
    Pengalaman / Experience : 12 tahun/years(s)

    BIOLOGY :PURE AND APPLIED SCIENCES
    Next Generation Sequencing, Transcriptomics, Single cell RNA sequencing, Whole Genome Sequencing, Whole exome sequencing, Targeted sequencing, Microarray, qPCR, Bioinformatics ,,,,,,,,,,
    Pengalaman / Experience : 12 tahun/years(s)

    ONCOLOGY :CLINICAL AND HEALTH SCIENCES
    Cancer biomarkers, Non-coding RNAs, Transcriptomics, Cell Culture, Liquid Biopsy, Circulating tumour cells
    Pengalaman / Experience : 16 tahun/years(s)

    BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
    NONCODING RNA
    Pengalaman / Experience : 11 tahun/years(s)