Biografi/ Biography :
Advances in sequencing techniques gave rise to the rapid increase of new sequences. Yet, resolving the protein structure is complicated and time-consuming, creating an ever-widening “Protein structure gap”. With a mission to narrow the gap using computational tools, Su Datt pursued his PhD in Bioinformatics at University College London. Obtaining a good template is key to the success of protein structure modelling. During his PhD, he developed a template searching protocol that produced higher percentages of good quality modes compared to the state-of-the-art template searching protocol. His modelling platform has been applied to model >70% of the structurally uncharacterised proteins for >14 model organisms.
After graduated from his PhD, he embarked on a study to understand the biological impacts of mutually exclusive exon splicing (MXE) in 5 different genomes. MXE-specific residues tend to be surface exposed and cluster near protein functional sites. MXEs tend to maintain the protein fold, but alter the specificity and selectivity of protein functions. These results suggest MXEs may have some important roles in cells and also in cancer. He recently acquired a research grant to study the structure of proteins found in a fungus living in Antarctica. Studying proteins found in harsh environment may lead to the finding of new enzymes that may be in industrial applications or possible bioproducts.
vaishali p. waman, paul ashford, su datt lam, neeladri sen, mahnaz abbasian, laurel woodridge, yonathan goldtzvik, nicola bordin, jiaxin wu, ian sillitoe, christine a. orengo. (2024). predicting human and viral protein variants affecting covid-19 susceptibility and repurposing therapeutics. - scientific reports. 1-19.
nazlina bt. ibrahim;mohamad azwani shah bin mat lazim;norefrina shafinaz binti md nor;lam su datt. (2024). structure-activity relationship and elucidation of the antiviral mechanism of selected plants using metabolomics approach. - . .
khairul azreena bakar, lam su datt, low chen fei, shevin rizal feroz. (2023). binding mechanism of mitragynine to alpha-1-acid glycoprotein: multi-spectroscopic and molecular modelling approaches. - 1st natural science and technology conference (nastec) 2023. 1-2.
tung zheng kun, lam su datt, nazlina ibrahim, norefrina shafinaz md nor. (2023). in silico screening and in vitro analysis of neem (azadirachta indica) for antiviral activity towards rna viruses. - simposium biologi kebangsaan 2023 & the 4th joint seminar on plant sciences and products. 39.
aidil bin abdul hamid;farah diba bt. abu bakar;izyanti binti ibrahim;lam su datt;shazilah binti kamaruddin. (2023). elucidation of the dynamics of lipogenic metabolon formation in cunninghamella bainieri 2a1 and prediction of its structural organisation. - . .
vaishali p. waman, paul ashford, su datt lam, neeladri sen, mahnaz abbasian, laurel woodridge, yonathan goldtzvik, nicola bordin, jiaxin wu, ian sillitoe, christine a. orengo. (2024). predicting human and viral protein variants affecting covid-19 susceptibility and repurposing therapeutics. - scientific reports. 1-19.
siti nur hidayah jamil, amatul hamizah ali, shevin rizal feroz, su datt lam, hani kartini agustar, mohd ridzuan mohd abd razak, jalifah latip. (2023). curcumin and its derivatives as potential antimalarial and anti inflammatory agents a review on structure activity relationship and mechanism of action. - pharmaceuticals. 1-25.
yonathan goldtzvik, neeladri sen, su datt lam, christine orengo. (2023). protein diversification through post-translational modifications, alternative splicing, and gene duplication. - current opinion in structural biology. 1-10.
nicola bordin, ian sillitoe, vamsi nallapareddy, clemens rauer, su datt lam, vaishali p. waman, neeladri sen, michael heinzinger, maria littmann, stephanie kim, sameer velankar, martin steinegger, burkhard rost, christine orengo. (2023). alphafold2 reveals commonalities and novelties in protein structure space for 21 model organisms. - communications biology. 1-12.
danish sanuri, ahmad al-khdhairawi, rahmad akbar, su datt lam, shobana sugumar, nazlina ibrahim, sylvia chieng, fareed sairi. (2023). machine learning and molecular simulation ascertain antimicrobial peptide against klebsiella pneumoniae from public database. - computational biology and chemistry. 1-13.
xin-wei lee, su datt lam, mohd firdaus-raih, kiew-lian wan. (2020). molecular characterisation of eimeria tenella porin, a potential anticoccidial drug target. - sains malaysiana. 755-764.
vaishali p. waman, paul ashford, su datt lam, neeladri sen, mahnaz abbasian, laurel woodridge, yonathan goldtzvik, nicola bordin, jiaxin wu, ian sillitoe, christine a. orengo. (2024). predicting human and viral protein variants affecting covid-19 susceptibility and repurposing therapeutics. - scientific reports. 1-19.
yonathan goldtzvik, neeladri sen, su datt lam, christine orengo. (2023). protein diversification through post-translational modifications, alternative splicing, and gene duplication. - current opinion in structural biology. 1-10.
siti nur hidayah jamil, amatul hamizah ali, shevin rizal feroz, su datt lam, hani kartini agustar, mohd ridzuan mohd abd razak, jalifah latip. (2023). curcumin and its derivatives as potential antimalarial and anti inflammatory agents a review on structure activity relationship and mechanism of action. - pharmaceuticals. 1-25.
nicola bordin, ian sillitoe, vamsi nallapareddy, clemens rauer, su datt lam, vaishali p. waman, neeladri sen, michael heinzinger, maria littmann, stephanie kim, sameer velankar, martin steinegger, burkhard rost, christine orengo. (2023). alphafold2 reveals commonalities and novelties in protein structure space for 21 model organisms. - communications biology. 1-12.
danish sanuri, ahmad al-khdhairawi, rahmad akbar, su datt lam, shobana sugumar, nazlina ibrahim, sylvia chieng, fareed sairi. (2023). machine learning and molecular simulation ascertain antimicrobial peptide against klebsiella pneumoniae from public database. - computational biology and chemistry. 1-13.
natalie l. dawson, ian sillitoe, jonathan g. lees, su datt lam & christine a. orengo. (2017). protein bioinformatics from protein modifications and networks to proteomics. - . 32.
nazlina bt. ibrahim;mohamad azwani shah bin mat lazim;norefrina shafinaz binti md nor;lam su datt. (2024). structure-activity relationship and elucidation of the antiviral mechanism of selected plants using metabolomics approach. - . .
abuthakir, mh.syed , datt, lam.su , firdaus, mr.mohd , nathan, sheila and leong, ng.chyan. (2023). in silico structural and functional annotation of hypothetical proteins of burkholderia pseudomallei k96243. - asian regional conference on systems biology 2023. 54.
aidil bin abdul hamid;farah diba bt. abu bakar;izyanti binti ibrahim;lam su datt;shazilah binti kamaruddin. (2023). elucidation of the dynamics of lipogenic metabolon formation in cunninghamella bainieri 2a1 and prediction of its structural organisation. - . .
khairun nisha japlus, lam su datt, sobri hussein, nurulhikma md isa. (2023). oryza sativa stress associated protein 4 (ossap4) cloning and germination analysis in arabidopsis transgenic. - 33rd malaysian society of plant physiology conference (mspp) 2023. 14.
khairul azreena bakar, lam su datt, low chen fei, shevin rizal feroz. (2023). binding mechanism of mitragynine to alpha-1-acid glycoprotein: multi-spectroscopic and molecular modelling approaches. - 1st natural science and technology conference (nastec) 2023. 1-2.
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