pensyarah universiti
institut biologi molekul perubatan ukm (umbi)
m.aimanmohtar@ppukm.ukm.edu.my
Kluster Kepakaran/ Cluster of Expertise :
Kesihatan dan Perubatan Termaju,
Biografi/ Biography :
M. Aiman Mohtar is a Research Fellow at the UKM Medical Molecular Biology Institute (UMBI), The National University of Malaysia. He previously earned his BSc. (Biotechnology) with highest honours from Rochester Institute of Technology, New York and MSc. (Molecular Biology) from University of Pennsylvania, Philadelphia. He completed his PhD in Molecular and Clinical Medicine at Institute of Genetics and Molecular Medicine, University of Edinburgh. His PhD thesis focuses on identification of protein-protein interaction network of an oncogenic ER-resident protein. He has been trained as molecular biologist for more than a decade and has involved in research utilizing cutting- edge laboratory techniques such as CRISPR-Cas9 genome editing tools, fluorescence microscopy, phage display and quantitative proteomics. Aiman’s current research focus is studying protein-protein interaction and tumour cell secretory addiction in AGR2 signalling axis using multi-omics approach and developing therapeutic tools targeting pro-oncogenic molecules. To date, he has secured several UKM, national and international grants.
m. aiman mohtar, saiful effendi syafruddin, muhammad-redha abdullah-zawawi, muhammad irfan abdul jalal, teck yew low, shing cheng tan. (2026). integrated approach to precision oncology. - interdisciplinary cancer research. 407 - 427.
mohd hafiz bin baharuddin ,saiful effendi bin syafruddin ,mohamad aimanuddin bin mohtar . (2026). comb structured wearable metamaterial with electrical conductivity for health monitoring garment of severe patients. - . .
m. aiman mohtar, siti nurmi nasir, zuraini abd razak, hanif zulkhairi mohamad said, syazalina zahari, saiful effendi syafruddin. (2026). rna-seq analysis reveals regulatory networks driven by epcam overexpression in esophageal adenocarcinoma cells. - peerj. 1 - 24.
chia yuh cai, saiful effendi syafruddin, m. aiman mohtar. (2026). strategi terapeutik berasaskan crispr: sempadan baru dalam rawatan kanser payudara. - jurnal sains kesihatan malaysia. 92 - 105.
norfarhana mazlan, saiful effendi syafruddin, mohd khairul nizam mohd khalid, mohamad aimanuddin mohtar, yuslina mat yusoff. (2025). integrated epigenomic and transcriptomic profiling reveals cell cycle dysregulation in cytogenetically normal acute myeloid leukaemia. - aacr on campus malaysia 2025. .
m. aiman mohtar, siti nurmi nasir, zuraini abd razak, hanif zulkhairi mohamad said, syazalina zahari, saiful effendi syafruddin. (2026). rna-seq analysis reveals regulatory networks driven by epcam overexpression in esophageal adenocarcinoma cells. - peerj. 1 - 24.
safaa m. naes, sharaniza ab-rahim, musalmah mazlan, saiful effendi syafruddin,m. aiman mohtar, asmaa y. abuhamad, amirah abdul rahman. (2025). crispr/cas9 mediated ent2 gene knockout altered purine catabolic pathway and induced apoptosis in colorectal cell lines. - plos one. 1 - 16.
nurul nadia mohamad zamberi, asmaa y abuhamad, teck yew low, m aiman mohtar, saiful effendi syafruddin. (2024). dcas9 tells tales: probing gene function and transcription regulation in cancer. - the crispr journal. 73-87.
m. aiman mohtar, siti nur hasanah mohd yusuf, and saiful effendi syafruddin. (2024). cholesterol accumulation in ccrcc: the role of ccrcc-initiating vhl-hifa pathway. - ebiomedicine. 1-2.
syazalina zahari, saiful effendi syafruddin and m. aiman mohtar. (2023). impact of the cancer cell secretome in driving breast cancer progression. - cancers. 1-17.
saiful effendi syafruddin, wan fahmi wan mohamad nazarie, nurshahirah ashikin moidu, bee hong soon, m. aiman mohtar. (2021). integration of rna-seq and proteomics data identifies glioblastoma multiforme surfaceome signature. - bmc cancer. 1-13.
m. aiman mohtar, siti nurmi nasir, zuraini abd razak, hanif zulkhairi mohamad said, syazalina zahari, saiful effendi syafruddin. (2026). rna-seq analysis reveals regulatory networks driven by epcam overexpression in esophageal adenocarcinoma cells. - peerj. 1 - 24.
ma1gorzata lisowska, erin g. worrall,filip zavadil-kokas, keith charlton, euan murray, m. aiman mohtar, radovan krejcir, vaclav hrabal, jack brydon, ainhoa gonzalez urionabarrenetxea,david g. saliba, mariana grima, umesh kalathiya, petr muller, adam krejci, borivoj vojtesek, kathryn l. ball,2robin fahraeus, david j. argyle, maciej parys, and ted r. hupp. (2025). the development of a canine single-chain phage antibody library to isolate recombinant antibodies for use in translational cancer research. - cell reports methods. 1 - 28.
nurul nadia mohamad zamberi, siti nur hasanah mohd yusufb m. aiman mohtar, saiful effendi syafruddin. (2025). uncovering the transcription factor network driving klf6 expression through super enhancers in renal cell carcinoma. - asian pacific journal of molecular biology and biotechnology. 17 - 17.
safaa m. naes, sharaniza ab-rahim, musalmah mazlan, saiful effendi syafruddin,m. aiman mohtar, asmaa y. abuhamad, amirah abdul rahman. (2025). crispr/cas9 mediated ent2 gene knockout altered purine catabolic pathway and induced apoptosis in colorectal cell lines. - plos one. 1 - 16.
m. aiman mohtar, siti nur hasanah mohd yusuf, and saiful effendi syafruddin. (2024). cholesterol accumulation in ccrcc: the role of ccrcc-initiating vhl-hifa pathway. - ebiomedicine. 1-2.
m. aiman mohtar, saiful effendi syafruddin, muhammad-redha abdullah-zawawi, muhammad irfan abdul jalal, teck yew low, shing cheng tan. (2026). integrated approach to precision oncology. - interdisciplinary cancer research. 407 - 427.
muhammad-redha abdullah-zawawi, shing cheng tan, m. aiman mohtar, saiful effendi syafruddin, teck yew low, muhammad irfan abdul jalal. (2025). unveiling cancer complexity: machine learning insights into multi-omics data. - . 51 - 69.
saiful effendi syafruddin, mohamad aimanuddin mohtar, tan shing cheng, nadiah abu, nor aidatulakma abdullah@muda, nurul syakima ab mutalib, chin siok fong, neoh hui min, rahman jamal, nor azian abdul murad. (2019). umbi initiatives on colorectal cancer biomarkers discovery. - . 19-28.
chia yuh cai, saiful effendi syafruddin, m. aiman mohtar. (2026). strategi terapeutik berasaskan crispr: sempadan baru dalam rawatan kanser payudara. - jurnal sains kesihatan malaysia. 92 - 105.
nurul nadia mohamad zamberi, mohd raziff alias, m. aiman mohtar, saiful effendi syafruddin. (2025). aplikasi teknologi crispr/cas9 dan penyuntingan perdana dalam kajian biologi molekul dan kefungsian gen. - jurnal sains kesihatan malaysia. 67 - 79.
mohamad aimanuddin mohtar. (2023). penyuntingan baka secara tidak terkawal lahirkan manusia mutan. - berita harian. 1.
yuh cai chia, sundharavalli ramayah , nurul nadia mohamad zamberi, mohamad aimanuddin mohtar , saiful effendi syafruddin. (2023). crispr/cas9: teknik penyuntingan dan modifikasi gen. - . 1.
siti nur hasanah mohd yusuf, m. aiman mohtar, saiful effendi syafruddin. (2023). penyahkawalseliaan proses transkripsi dalam patogenesis kanser. - majalah dewan kosmik. 50-53.
mohd hafiz bin baharuddin ,saiful effendi bin syafruddin ,mohamad aimanuddin bin mohtar . (2026). comb structured wearable metamaterial with electrical conductivity for health monitoring garment of severe patients. - . .
norfarhana mazlan, saiful effendi syafruddin, mohd khairul nizam mohd khalid, mohamad aimanuddin mohtar, yuslina mat yusoff. (2025). integrated epigenomic and transcriptomic profiling reveals cell cycle dysregulation in cytogenetically normal acute myeloid leukaemia. - aacr on campus malaysia 2025. .
saiful effendi syafruddin, mohamad aimanuddin mohtar. (2025). crispr diy: step by step genome editing protocols in mammalian cells. - . .
nur qurratu’ athirah a rahman, norfarhana mazlan, rahman jamal, ahmad suhail khazali, mohamad aimanuddin mohtar, saiful effendi syafruddin. (2025). transcriptomic profiling of dual hif2a and klf6 repression reveals a co-regulatory network driving ccrcc progression. - aacr on campus malaysia 2025. .
mohamad aimanuddin mohtar. (2025). rewriting the code of life: exploring the power of crispr-cas9. - . .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| ELUCIDATING THE CROSSTALK BETWEEN HIF2α-VEGFA AND KLF6-PDGFβ AXES IN DRIVING RENAL CARCINOMA HYPERVASCULARIZATION | nanoarms sdn. bhd. | 97.8% (2023-10-01 sehingga 2026-03-31) |
| ELUCIDATING THE CROSSTALK BETWEEN HIF2α-VEGFA AND KLF6-PDGFβ AXES IN DRIVING RENAL CARCINOMA HYPERVASCULARIZATION | genomax technologies sdn bhd | 97.8% (2023-10-01 sehingga 2026-03-31) |
| FLUORESCENCE-BASED LAMP–CRISPR ASSAY FOR BLOOD-BASED SCREENING OF HIGH-RISK HPV GENOTYPES LINKED TO CERVICAL CANCER | next gene scientific sdn. bhd. | 13.7% (2025-12-01 sehingga 2027-11-30) |
| COPPER-FREE CLICK CHEMISTRY–MEDIATED CONJUGATION OF CEA/CD3 BISPECIFIC ANTIBODIES TO EXTRACELLULAR VESICLES FOR IMMUNOTHERAPEUTIC APPLICATIONS | cytonex sdn bhd | 13.7% (2025-12-01 sehingga 2027-11-30) |
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Molecular Biology
Pengalaman / Experience : 10 tahun/years(s)
BIOTECHNOLOGY :PURE AND APPLIED SCIENCES
Cancer Proteomics
Pengalaman / Experience : 5 tahun/years(s)