pensyarah universiti
institut biologi molekul perubatan ukm (umbi)
m.aimanmohtar@ppukm.ukm.edu.my
Kluster Kepakaran/ Cluster of Expertise :
Kesihatan dan Perubatan Termaju,
Biografi/ Biography :
M. Aiman Mohtar is a Research Fellow at the UKM Medical Molecular Biology Institute (UMBI), The National University of Malaysia. He previously earned his BSc. (Biotechnology) with highest honours from Rochester Institute of Technology, New York and MSc. (Molecular Biology) from University of Pennsylvania, Philadelphia. He completed his PhD in Molecular and Clinical Medicine at Institute of Genetics and Molecular Medicine, University of Edinburgh. His PhD thesis focuses on identification of protein-protein interaction network of an oncogenic ER-resident protein. He has been trained as molecular biologist for more than a decade and has involved in research utilizing cutting- edge laboratory techniques such as CRISPR-Cas9 genome editing tools, fluorescence microscopy, phage display and quantitative proteomics. Aiman’s current research focus is studying protein-protein interaction and tumour cell secretory addiction in AGR2 signalling axis using multi-omics approach and developing therapeutic tools targeting pro-oncogenic molecules. To date, he has secured several UKM, national and international grants.
nur qurratu’ athirah a rahman, rahman jamal, ahmad suhail khazali, mohamad aimanuddin mohtar, saiful effendi syafruddin . (2026). dual targeting of hif-2a and klf6 suppresses angiogenic signaling in clear cell renal cell carcinoma (ccrcc). - 1st regional conference on precision health (rcph). .
muhammad-redha abdullah-zawawi, atiqah syahira muhamad azuan, nor afiqah-aleng, muhammad asyaari zakaria, loscheni varma, nur alyaa afifah md shahri, shing cheng tan, m. aiman mohtar, woon lee yong and hafiza alauddin. (2026). graph cluster approach in identifying novel proteins and significant pathways involved in acute myeloid leukemia. - 1st regional conference on precision health (rcph). .
nurul nadia mohamad zamberi, asmaa y. abuhamad, siti nur hasanah mohd yusuf, nur qurratu athirah a. rahman, mohamad aimanuddin mohtar and saiful effendi syafruddin. (2026). perturbation of brd4 and p300 activity suppresses super enhancer-driven klf6 expression in renal carcinoma. - oncology reports. 1 - 13.
mohamad aimanuddin mohtar, yuh cai chia , saiful effendi syafruddin, muhammad-redha abdullah-zawawi, ted hupp, delphine fessart . (2026). dissecting the cis- and trans-regulatory architecture governing agr2 expression in estrogen receptor-positive breast cancer. - esmo open. 7 - 8.
m. aiman mohtar, saiful effendi syafruddin, muhammad-redha abdullah-zawawi, muhammad irfan abdul jalal, teck yew low, shing cheng tan. (2026). integrated approach to precision oncology. - interdisciplinary cancer research. 407 - 427.
nurul nadia mohamad zamberi, asmaa y. abuhamad, siti nur hasanah mohd yusuf, nur qurratu athirah a. rahman, mohamad aimanuddin mohtar and saiful effendi syafruddin. (2026). perturbation of brd4 and p300 activity suppresses super enhancer-driven klf6 expression in renal carcinoma. - oncology reports. 1 - 13.
mohamad aimanuddin mohtar, yuh cai chia , saiful effendi syafruddin, muhammad-redha abdullah-zawawi, ted hupp, delphine fessart . (2026). dissecting the cis- and trans-regulatory architecture governing agr2 expression in estrogen receptor-positive breast cancer. - esmo open. 7 - 8.
m. aiman mohtar, siti nurmi nasir, zuraini abd razak, hanif zulkhairi mohamad said, syazalina zahari, saiful effendi syafruddin. (2026). rna-seq analysis reveals regulatory networks driven by epcam overexpression in esophageal adenocarcinoma cells. - peerj. 1 - 24.
safaa m. naes, sharaniza ab-rahim, musalmah mazlan, saiful effendi syafruddin,m. aiman mohtar, asmaa y. abuhamad, amirah abdul rahman. (2025). crispr/cas9 mediated ent2 gene knockout altered purine catabolic pathway and induced apoptosis in colorectal cell lines. - plos one. 1 - 16.
nurul nadia mohamad zamberi, asmaa y abuhamad, teck yew low, m aiman mohtar, saiful effendi syafruddin. (2024). dcas9 tells tales: probing gene function and transcription regulation in cancer. - the crispr journal. 73-87.
m. aiman mohtar, delphine fessart, chia yuh cai, syazalina zahari, saiful effendi syafruddin, muhammad-redha abdullah-zawawi, ted hupp. (2025). crispr-mediated agr2 repression reveals esr1-driven transcriptional control in breast cancer cells. - asia-pacific journal of clinical oncology. 6 - 6.
saiful effendi syafruddin, wan fahmi wan mohamad nazarie, nurshahirah ashikin moidu, bee hong soon, m. aiman mohtar. (2021). integration of rna-seq and proteomics data identifies glioblastoma multiforme surfaceome signature. - bmc cancer. 1-13.
nurul nadia mohamad zamberi, asmaa y. abuhamad, siti nur hasanah mohd yusuf, nur qurratu athirah a. rahman, mohamad aimanuddin mohtar and saiful effendi syafruddin. (2026). perturbation of brd4 and p300 activity suppresses super enhancer-driven klf6 expression in renal carcinoma. - oncology reports. 1 - 13.
mohamad aimanuddin mohtar, yuh cai chia , saiful effendi syafruddin, muhammad-redha abdullah-zawawi, ted hupp, delphine fessart . (2026). dissecting the cis- and trans-regulatory architecture governing agr2 expression in estrogen receptor-positive breast cancer. - esmo open. 7 - 8.
m. aiman mohtar, siti nurmi nasir, zuraini abd razak, hanif zulkhairi mohamad said, syazalina zahari, saiful effendi syafruddin. (2026). rna-seq analysis reveals regulatory networks driven by epcam overexpression in esophageal adenocarcinoma cells. - peerj. 1 - 24.
safaa m. naes, sharaniza ab-rahim, musalmah mazlan, saiful effendi syafruddin,m. aiman mohtar, asmaa y. abuhamad, amirah abdul rahman. (2025). crispr/cas9 mediated ent2 gene knockout altered purine catabolic pathway and induced apoptosis in colorectal cell lines. - plos one. 1 - 16.
nurul nadia mohamad zamberi, siti nur hasanah mohd yusufb m. aiman mohtar, saiful effendi syafruddin. (2025). uncovering the transcription factor network driving klf6 expression through super enhancers in renal cell carcinoma. - asian pacific journal of molecular biology and biotechnology. 17 - 17.
m. aiman mohtar, saiful effendi syafruddin, muhammad-redha abdullah-zawawi, muhammad irfan abdul jalal, teck yew low, shing cheng tan. (2026). integrated approach to precision oncology. - interdisciplinary cancer research. 407 - 427.
muhammad-redha abdullah-zawawi, shing cheng tan, m. aiman mohtar, saiful effendi syafruddin, teck yew low, muhammad irfan abdul jalal. (2025). unveiling cancer complexity: machine learning insights into multi-omics data. - . 51 - 69.
saiful effendi syafruddin, mohamad aimanuddin mohtar, tan shing cheng, nadiah abu, nor aidatulakma abdullah@muda, nurul syakima ab mutalib, chin siok fong, neoh hui min, rahman jamal, nor azian abdul murad. (2019). umbi initiatives on colorectal cancer biomarkers discovery. - . 19-28.
chia yuh cai, saiful effendi syafruddin, m. aiman mohtar. (2026). strategi terapeutik berasaskan crispr: sempadan baru dalam rawatan kanser payudara. - jurnal sains kesihatan malaysia. 92 - 105.
nurul nadia mohamad zamberi, mohd raziff alias, m. aiman mohtar, saiful effendi syafruddin. (2025). aplikasi teknologi crispr/cas9 dan penyuntingan perdana dalam kajian biologi molekul dan kefungsian gen. - jurnal sains kesihatan malaysia. 67 - 79.
siti nur hasanah mohd yusuf, m. aiman mohtar, saiful effendi syafruddin. (2023). penyahkawalseliaan proses transkripsi dalam patogenesis kanser. - majalah dewan kosmik. 50-53.
yuh cai chia, sundharavalli ramayah , nurul nadia mohamad zamberi, mohamad aimanuddin mohtar , saiful effendi syafruddin. (2023). crispr/cas9: teknik penyuntingan dan modifikasi gen. - . 1.
mohamad aimanuddin mohtar. (2023). penyuntingan baka secara tidak terkawal lahirkan manusia mutan. - berita harian. 1.
nur qurratu’ athirah a rahman, rahman jamal, ahmad suhail khazali, mohamad aimanuddin mohtar, saiful effendi syafruddin . (2026). dual targeting of hif-2a and klf6 suppresses angiogenic signaling in clear cell renal cell carcinoma (ccrcc). - 1st regional conference on precision health (rcph). .
muhammad-redha abdullah-zawawi, atiqah syahira muhamad azuan, nor afiqah-aleng, muhammad asyaari zakaria, loscheni varma, nur alyaa afifah md shahri, shing cheng tan, m. aiman mohtar, woon lee yong and hafiza alauddin. (2026). graph cluster approach in identifying novel proteins and significant pathways involved in acute myeloid leukemia. - 1st regional conference on precision health (rcph). .
mohd hafiz bin baharuddin ,saiful effendi bin syafruddin ,mohamad aimanuddin bin mohtar . (2026). comb structured wearable metamaterial with electrical conductivity for health monitoring garment of severe patients. - . .
saiful effendi syafruddin, mohamad aimanuddin mohtar. (2025). crispr diy: step by step genome editing protocols in mammalian cells. - . .
mohamad aimanuddin mohtar. (2025). rewriting the code of life: exploring the power of crispr-cas9. - . .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| FLUORESCENCE-BASED LAMP–CRISPR ASSAY FOR BLOOD-BASED SCREENING OF HIGH-RISK HPV GENOTYPES LINKED TO CERVICAL CANCER | next gene scientific sdn. bhd. | 22.9% (2025-12-01 sehingga 2027-11-30) |
| COPPER-FREE CLICK CHEMISTRY–MEDIATED CONJUGATION OF CEA/CD3 BISPECIFIC ANTIBODIES TO EXTRACELLULAR VESICLES FOR IMMUNOTHERAPEUTIC APPLICATIONS | cytonex sdn bhd | 22.9% (2025-12-01 sehingga 2027-11-30) |
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Molecular Biology
Pengalaman / Experience : 10 tahun/years(s)
BIOTECHNOLOGY :PURE AND APPLIED SCIENCES
Cancer Proteomics
Pengalaman / Experience : 5 tahun/years(s)