Biografi/ Biography :
My research career officially started with my PhD at the University of Cambridge, UK, under the supervision of Prof Morris J Brown in 2008-2012. There I developed my interest in the disease primary aldosteronism, a common cause for curable secondary hypertension. Upon completion of my PhD, I continued as a research associate with Prof Morris J Brown’s group until the end of 2013, before starting my career here at the National University of Malaysia (UKM) Medical Center. During my period in Cambridge, we managed to characterize the genetics and histology of adenomas causing primary aldosteronism into two groups – those that were similar to the outer layer of the adrenal cortex (the zona glomerulosa) and those that were similar to the middle layer of the adrenal cortex (the zona fasciculata). The findings were presented at several international scientific meetings which led to the attainment of the Austin Doyle (Servier) Award at the 24th International Scientific Meeting of the International Hypertension (ISH) in Sydney, Australia, and the Young Investigator Award at the 39th International Aldosterone Conference in San Francisco, USA. As hypertension affects at least one third of adults in Malaysia, research on primary aldosteronism is essential to be continued in Malaysia. Hence, I am still continuing my research on primary aldosteronism locally here in Malaysia in addition to focusing on the cell-fate/cell function of the zona glomerulosa in the adrenal glands through international collaborations with my PhD supervisor Prof Morris J Brown and co-investigators during my time in Cambridge. This has led to the recognition of the research locally in Malaysia as highlighted by the ASEAN Federation of Endocrine Societies (AFES) Investigator Award received in 2015 and the Young Investigator Award (Basic Science) received during the Malaysian Endocrine & Metabolic Society 8th Annual Congress (MAC8) in 2017.
mohd shahrir bin mohamed said;rahana binti abd rahman;shamsul azhar bin shah;elena aisha binti azizan. (2024). obstetric antiphospholipid syndrome (oaps): a multicenter pilot study of the association between antiphospholipid antibodies and genetic biomarker of the targeted genotypes to the adverse pregnancy outcomes in malaysian oaps patients”. - . .
elena aisha binti azizan. (2024). unesco loreal for women in science bridges gender gap. - the malaysian reserve. 1.
kha chin long, gee huey leong, muhammad hasrul rosli, noor syazmeera abdul rahman, nor falina ahmad tajuddin, wan norshatira wan hurairah, chin tat ng, norlinah mohamed ibrahim, elena aisha azizan. (2023). development of a genetic screening method for polyglutamine expansion spinocerebellar ataxias in universiti kebangsaan malaysia medical centre. - malaysian journal of human genetics. 28-36.
m naruse, m murakami, t katabami...norlela sukor, elena a.b. aisha azizan.... (2023). international multicenter survey on screening and confirmatory testing in primary aldosteronism. - european journal of endocrinology. 1-10.
elena aisha binti azizan. (2023). sin chew education point: 2023 l'oreal anugerah wanita cemerlang dalam sains. - sin chew. 25.
fatin athirah pauzi, elena aisha azizan, muaatamarulain mustangin, geok chin tan, norlela sukor, ales ryska, jiri ceral, miroslav solar, azraai bahari nasruddin. (2023). distribution of cacna1d somatic mutations among cyp11b2 immunohistochemistry-guided samples of aldosterone-producing adenoma (apa). - journal of hypertension. e280-e281.
siti khadijah syed mohammed nazri, rozman zakaria, nor azian abdul murad, rohaizak muhammad, geok chin tan, norlela sukor, elena aisha azizan. (2023). identification of aldosterone-driver somatic mutations in cell-free dna from adrenal vein samples of primary aldosteronism patients. - journal of hypertension. e487.
kha chin long, norlela sukor, geok chin tan, nor azian abdul murad, morris jonathan brown, elena aisha azizan. (2023). elucidating effect of inhibiting aldosterone synthesis on human adrenocortical cells. - journal of hypertension. e362.
elena aisha azizan. (2023). histopathology-genotype correlation of aldosterone- producing adenomas. - journal of hypertension. e121-e122.
nurfatin syazreen mohd rizam, muaatamarulain mustangin, geok chin tan, norlela sukor, fatin saparuddin, fatin athirah pauzi, siti khadijah syed muhammad nazri, azraai bahari nasruddin, elena aisha azizan. (2023). prevalence of kcnj5 mutant aldosterone-producing adenomas among malaysian patients with primary aldosteronism. - journal of hypertension. e280.
giulia argentesi, junhua zhou, elena azizan, claudia p cabrera, emily cottrell, xilin wu, emily goodchild, roger foo, chaz mein, eva wozniak, william drake, helen storr, morris brown. (2021). aldosterone-producing adenomas with dual mutations of gna11/q and ctnnb1 lead to hypertension in puberty, pregnancy or menopause, and complete cure by adrenalectomy. - journal of human hypertension. 5.
noor syazwani izyan a, abdul khalif adha, elena aisha azizan, nor azian abdul murad, noraidatulakma abdullah, mohd shahrir mohamed said, ruslinda mustafar, abdul halim abdul gafor, zarina abdul latiff, syahrul sazliyana. (2021). associations of the malaysian susceptibility gene loci of systemic lupus erythematosus (sle) with lupus nephritis and treatment response. - international journal of rheumatic diseases. 308-309.
elena azizan, morris brown. (2020). ace2 role in sars-cov-2 infectivity and covid-19 severity. - malaysian journal of pathology. 1-6.
s. jayakumar, elena azizan, shamsul azhar shah, arbaiyah bain & abdul halim abdul gafor. (2020). vitamin k status in diabetic patients with chronic kidney disease stage 3-5 and its effects on chronic kidney disease - mineral bone disorder. - sains malaysiana. 613-624.
afifah binti azam, elena aisha binti azizan. (2018). brief overview of a decade of genome-wide association studies on primary hypertension. - international journal of endocrinology. 1-14.
xilin wu, elena a.b. azizan, emily goodchild, sumedha garg, man hagiyama, claudia p. cabrera, fabio l. fernandes-rosa, sheerazed boulkroun, jyn ling kuan, zenia tiang, alessia david, masanori murakami, charles a. mein, eva wozniak, wanfeng zhao, et al.. (2023). somatic mutations of cadm1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production. - nature genetics. 1009-1021.
li-chin chen, wei-chieh huang, kang-yung peng, ying-ying chen, szu-chang li, siti khadijah syed mohammed nazri, yen-hung lin, liang-yu lin, tse-min lu, jung hee kim, elena aisha azizan, jinbo hu, qifu li, jeff s. chueh, vin-cent wu, taipai study group. (2023). identifying kcnj5 mutation in aldosterone-producing adenoma patients with baseline characteristics using machine learning technology. - jacc: asia. 664-675.
kate laycock, claudia cabrera, eva wozniak, charles mein, elena azizan, xilin wu, giulia argentesi, emily goodchild, william drake, morris jonathan brown. (2023). using single cell technology to predict the cell of origin of aldosterone-producing adrenal adenomas. - journal of the endocrine society. A355-A356.
nurfatin syazreen mohd rizam, muaatamarulain mustangin, geok chin tan, norlela sukor, fatin saparuddin, fatin athirah pauzi, siti khadijah syed muhammad nazri, azraai bahari nasruddin, elena aisha azizan. (2023). prevalence of kcnj5 mutant aldosterone-producing adenomas among malaysian patients with primary aldosteronism. - journal of hypertension. e280.
fatin athirah pauzi, elena aisha azizan, muaatamarulain mustangin, geok chin tan, norlela sukor, ales ryska, jiri ceral, miroslav solar, azraai bahari nasruddin. (2023). distribution of cacna1d somatic mutations among cyp11b2 immunohistochemistry-guided samples of aldosterone-producing adenoma (apa). - journal of hypertension. e280-e281.
mohd shahrir bin mohamed said;rahana binti abd rahman;shamsul azhar bin shah;elena aisha binti azizan. (2024). obstetric antiphospholipid syndrome (oaps): a multicenter pilot study of the association between antiphospholipid antibodies and genetic biomarker of the targeted genotypes to the adverse pregnancy outcomes in malaysian oaps patients”. - . .
elena aisha binti azizan. (2024). unesco loreal for women in science bridges gender gap. - the malaysian reserve. 1.
elena aisha binti azizan. (2023). sin chew education point: 2023 l'oreal anugerah wanita cemerlang dalam sains. - sin chew. 25.
elena aisha binti azizan. (2023). tekanan darah tinggi berpunca daripada hormon aldosteron boleh dirawat sepenuhnya tetapi gagal didiagnos. - bernama tinta minda. 1.
elena aisha binti azizan. (2023). the future is female. - astro awani. .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| EVALUATING THE EFFECT OF ALDOSTERONE SYNTHASE (CYP11B2) INHIBITION ON ADRENAL CELL FATE | l’oréal malaysia sdn. bhd. | 65.9% (2024-01-26 sehingga 2025-04-25) |
| THE ROLE OF SERUM NEUROFILAMENT LIGHT CHAIN FOR DISEASE ACTIVITY AND QUALITY OF LIFE OF CENTRAL NERVOUS SYSTEM DEMYELINATING DISORDERS | merck sdn bhd | 28.1% (2024-01-18 sehingga 2027-01-17) |