pensyarah universiti
jabatan perubatan
elena.azizan@ukm.edu.my
Kluster Kepakaran/ Cluster of Expertise :
Kesihatan dan Perubatan Termaju,
Biografi/ Biography :
My research career officially started with my PhD at the University of Cambridge, UK, under the supervision of Prof Morris J Brown in 2008-2012. There I developed my interest in the disease primary aldosteronism, a common cause for curable secondary hypertension. Upon completion of my PhD, I continued as a research associate with Prof Morris J Brown’s group until the end of 2013, before starting my career here at the National University of Malaysia (UKM) Medical Center. During my period in Cambridge, we managed to characterize the genetics and histology of adenomas causing primary aldosteronism into two groups – those that were similar to the outer layer of the adrenal cortex (the zona glomerulosa) and those that were similar to the middle layer of the adrenal cortex (the zona fasciculata). The findings were presented at several international scientific meetings which led to the attainment of the Austin Doyle (Servier) Award at the 24th International Scientific Meeting of the International Hypertension (ISH) in Sydney, Australia, and the Young Investigator Award at the 39th International Aldosterone Conference in San Francisco, USA. As hypertension affects at least one third of adults in Malaysia, research on primary aldosteronism is essential to be continued in Malaysia. Hence, I am still continuing my research on primary aldosteronism locally here in Malaysia in addition to focusing on the cell-fate/cell function of the zona glomerulosa in the adrenal glands through international collaborations with my PhD supervisor Prof Morris J Brown and co-investigators during my time in Cambridge. This research has been recognized locally by the ASEAN Federation of Endocrine Societies (AFES) Investigator Award (2015), the Young Investigator Award (Basic Science) from the Malaysian Endocrine & Metabolic Society (2017), the L`Oreal for women in science award Malaysia (2023), and the National Young Scientist Award (Medicine, 2024), and internationally recognized by the ENS@T scientific APA award (2021).
aina nadheera abd rahman and elena aisha azizan . (2025). somatic mutations associated with aldosterone-producing adenomas (apas). - genes. 1 - 23.
amnani aminuddin, elena aisha azizan. (2025). editorial: adrenal related hypertension: from bench to bedside, volume ii. - frontiers in endocrinology. 1 - 3.
fatin athirah pauzi, muaatamarulain mustangin, geok chin tan, ales ryska, jiri ceral, miroslav solar, elena aisha azizan. (2025). histopathological spectrum of common aldosterone-driver gene mutations in aldosterone-producing adenomas. - frontiers in medicine. 1 - 10.
elisabeth ng, yun-ni lee, angela taylor, fozia shaheen, elena azizan, william m. drake, and morris j. brown. (2025). evaluation of aldosterone suppression by cinnarizine, a putative cav1.3 inhibitor. - the journal of clinical endocrinology & metabolism. 2752 - 2761.
ns mohd rizam, m mustangin, fa pauzi, sk syed mohammed nazri, gc tan, n sukor, ab nasruddin, ea azizan. (2025). prevalence of kcnj5 mutations in aldosterone-producing adenomas among malaysian primary aldosteronism patients: genotype-phenotype correlation. - malaysian journal of pathology. 63 - 76.
amnani aminuddin, elena aisha azizan. (2025). editorial: adrenal related hypertension: from bench to bedside, volume ii. - frontiers in endocrinology. 1 - 3.
aina nadheera abd rahman and elena aisha azizan . (2025). somatic mutations associated with aldosterone-producing adenomas (apas). - genes. 1 - 23.
fatin athirah pauzi, muaatamarulain mustangin, geok chin tan, ales ryska, jiri ceral, miroslav solar, elena aisha azizan. (2025). histopathological spectrum of common aldosterone-driver gene mutations in aldosterone-producing adenomas. - frontiers in medicine. 1 - 10.
elisabeth ng, yun-ni lee, angela taylor, fozia shaheen, elena azizan, william m. drake, and morris j. brown. (2025). evaluation of aldosterone suppression by cinnarizine, a putative cav1.3 inhibitor. - the journal of clinical endocrinology & metabolism. 2752 - 2761.
elena aisha azizan, noorzaileen zaidi, amnani aminuddin, siti khadijah syed mohammed nazri, faeezah abdul latif, aina nadheera abd rahman, muaatamarulain mustangin, nani harlina md latar, rozman zakaria, nor adzimah johdi, adli ali, nor haslinda abd aziz, azraai bahari nasruddin, miroslav solar, norlela sukor. (2025). immune microenvironment profiling of primary aldosteronism. - journal of hypertension. 253 - 254.
ns mohd rizam, m mustangin, fa pauzi, sk syed mohammed nazri, gc tan, n sukor, ab nasruddin, ea azizan. (2025). prevalence of kcnj5 mutations in aldosterone-producing adenomas among malaysian primary aldosteronism patients: genotype-phenotype correlation. - malaysian journal of pathology. 63 - 76.
noor syazwani izyan a, abdul khalif adha, elena aisha azizan, nor azian abdul murad, noraidatulakma abdullah, mohd shahrir mohamed said, ruslinda mustafar, abdul halim abdul gafor, zarina abdul latiff, syahrul sazliyana. (2021). associations of the malaysian susceptibility gene loci of systemic lupus erythematosus (sle) with lupus nephritis and treatment response. - international journal of rheumatic diseases. 308-309.
giulia argentesi, junhua zhou, elena azizan, claudia p cabrera, emily cottrell, xilin wu, emily goodchild, roger foo, chaz mein, eva wozniak, william drake, helen storr, morris brown. (2021). aldosterone-producing adenomas with dual mutations of gna11/q and ctnnb1 lead to hypertension in puberty, pregnancy or menopause, and complete cure by adrenalectomy. - journal of human hypertension. 5.
s. jayakumar, elena azizan, shamsul azhar shah, arbaiyah bain & abdul halim abdul gafor. (2020). vitamin k status in diabetic patients with chronic kidney disease stage 3-5 and its effects on chronic kidney disease - mineral bone disorder. - sains malaysiana. 613-624.
elena azizan, morris brown. (2020). ace2 role in sars-cov-2 infectivity and covid-19 severity. - malaysian journal of pathology. 1-6.
amnani aminuddin, elena aisha azizan. (2025). editorial: adrenal related hypertension: from bench to bedside, volume ii. - frontiers in endocrinology. 1 - 3.
huai heng loh, elena aisha azizan, norlela sukor . (2025). connecting the dots: renin-angiotensin-aldosterone system, vitamin d, and hypertension.. - journal of hypertension. 1136 - 1145.
amalina haydar ali tajuddin, norlela sukor, elena aisha azizan, nor azmi kamaruddin, ahmad marzuki omar, geok chin tan, muaatamarulain mustangin, azmi alias, wan ruza iswati wan ismail, kartikasalwah abd latif, nurdillah idris, md nazim uddin, kamal rullah, nur firdaus isa, mohd hamzah mohd nasir. (2025). "tamoxifen for residual nf-pitnets: a proof-of-concept study integrating receptor profiling, pilot trial, and target pathway analysis. - endocrine. 863 - 876.
fatin athirah pauzi, muaatamarulain mustangin, geok chin tan, ales ryska, jiri ceral, miroslav solar, elena aisha azizan. (2025). histopathological spectrum of common aldosterone-driver gene mutations in aldosterone-producing adenomas. - frontiers in medicine. 1 - 10.
elisabeth ng, yun-ni lee, angela taylor, fozia shaheen, elena azizan, william m. drake, and morris j. brown. (2025). evaluation of aldosterone suppression by cinnarizine, a putative cav1.3 inhibitor. - the journal of clinical endocrinology & metabolism. 2752 - 2761.
nurfatin syazreen mohd rizam , fatin athirah pauzi , mun-kit choy , simon williams , amnani aminuddin , faeezah abdul latif , siti khadijah syed mohammed nazri , muaatamarulain mustangin , geok chin tan , xilin wu , elisabeth ng , kate laycock , norlela sukor , azraai bahari nasruddin , morris jonathan brown , bernard keavney, elena aisha azizan.. (2024). notch4 and gbp7 genetic contribution to primary aldosteronism pathology. - journal of the endocrine society. 132 - 133.
balint vekony, gabor nyiro, zoltan herold, janos fekete, filiipo ceccato, sven gruber, lydia kurzinger, mirko parasiliti-caprino, nikolette szucs, balint szeredas, siti khadija syed mohammed nazri, vanessa fell, mohamed bassiony, elena ab aisha azizan, irina bancos, felix beuschlein, peter igaz. (2024). machine learning-based differentiation of uni-and bilateral primary aldosteronism using circulating microrna combinations. - 26th european congress of endocrinology. 1 - 1.
elena aisha binti azizan. (2023). tekanan darah tinggi berpunca daripada hormon aldosteron boleh dirawat sepenuhnya tetapi gagal didiagnos. - bernama tinta minda. 1.
siti khadijah syed mohammed nazri, elena aisha azizan. (2022). hipertensi sekunder: gen-gen yang merangsang perembesan aldosteron yang berlebihan. - jurnal sains kesihatan malaysia. 51-63.
norlaila mustafa, zarina abdul latiff, alfizah hanafiah, salwati shuib, teoh seong lin, yogeswaran lokanathan, elena aisha azizan, mohd helmy mokhtar, tan jen kit, raja muhammad azlan shah raja alang m, nurul safaniza che ani. (2021). buku panduan pelajar program sarjana sains perubatan dan doktor falsafah (mod penyelidikan) fakulti perubatan universiti kebangsaan malaysia (ukm). - . 1-43.
elena ab azizan. (2021). syor pembedahan kelenjar adrenal. - harian metro. 40.
elena ab azizan, norlela b sukor. (2021). berpotensi pulih sepenuhnya. - metro. 38.
mohd shahrir bin mohamed said;rahana binti abd rahman;shamsul azhar bin shah;elena aisha binti azizan. (2024). obstetric antiphospholipid syndrome (oaps): a multicenter pilot study of the association between antiphospholipid antibodies and genetic biomarker of the targeted genotypes to the adverse pregnancy outcomes in malaysian oaps patients”. - . .
elena aisha binti azizan. (2024). unesco loreal for women in science bridges gender gap. - the malaysian reserve. 1.
elena aisha binti azizan. (2023). the future is female. - astro awani. .
elena aisha binti azizan. (2023). sin chew education point: 2023 l'oreal anugerah wanita cemerlang dalam sains. - sin chew. 25.
elena aisha binti azizan. (2023). tekanan darah tinggi berpunca daripada hormon aldosteron boleh dirawat sepenuhnya tetapi gagal didiagnos. - bernama tinta minda. 1.
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| EVALUATING THE EFFECT OF ALDOSTERONE SYNTHASE (CYP11B2) INHIBITION ON ADRENAL CELL FATE | l’oréal malaysia sdn. bhd. | 97.3% (2024-01-26 sehingga 2025-12-31) |
| THE ROLE OF SERUM NEUROFILAMENT LIGHT CHAIN FOR DISEASE ACTIVITY AND QUALITY OF LIFE OF CENTRAL NERVOUS SYSTEM DEMYELINATING DISORDERS | merck sdn bhd | 63.4% (2024-01-18 sehingga 2027-01-17) |
MEDICAL MOLECULAR BIOLOGY :BASIC MEDICAL SCIENCES
Primary Aldosteronism
Pengalaman / Experience : 10 tahun/years(s)
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Primary Aldosteronism
Pengalaman / Experience : tahun/years(s)