**Sumber data : e-REP.
   Tarikh kemaskini : 29-07-2020
dr. elena aisha binti azizan

pensyarah universiti

jabatan perubatan

No. rasmi:
UKM : 03 8921 5555



   Biografi/ Biography :
  • My research career officially started with my PhD at the University of Cambridge, UK, under the supervision of Prof Morris J Brown in 2008-2012. There I developed my interest in the disease primary aldosteronism, a common cause for curable secondary hypertension. Upon completion of my PhD, I continued as a research associate with Prof Morris J Brown’s group until the end of 2013, before starting my career here at the National University of Malaysia (UKM) Medical Center. During my period in Cambridge, we managed to characterize the genetics and histology of adenomas causing primary aldosteronism into two groups – those that were similar to the outer layer of the adrenal cortex (the zona glomerulosa) and those that were similar to the middle layer of the adrenal cortex (the zona fasciculata). The findings were presented at several international scientific meetings which led to the attainment of the Austin Doyle (Servier) Award at the 24th International Scientific Meeting of the International Hypertension (ISH) in Sydney, Australia, and the Young Investigator Award at the 39th International Aldosterone Conference in San Francisco, USA. As hypertension affects at least one third of adults in Malaysia, research on primary aldosteronism is essential to be continued in Malaysia. Hence, I am still continuing my research on primary aldosteronism locally here in Malaysia in addition to focusing on the cell-fate/cell function of the zona glomerulosa in the adrenal glands through international collaborations with my PhD supervisor Prof Morris J Brown and co-investigators during my time in Cambridge.

  • s. jayakumar, elena azizan, shamsul azhar shah, arbaiyah bain & abdul halim abdul gafor.  (2020).  vitamin k status in diabetic patients with chronic kidney disease stage 3-5 and its effects on chronic kidney disease - mineral bone disorder.  - sains malaysiana.  613-624. 

     

    noorasyikin ma, elena aa, teh pc, farah waheeda t, siti hajar md, long kc, norlinah mi.  (2020).  oral trehalose maybe helpful for patients with spinocerebellar ataxia 3 and should be better evaluated.  - parkinsonism and related disorders.  42-44. 

     

    elena aisha binti azizan;nor azmi bin kamaruddin;a. rahman bin a. jamal;rohaizak bin muhammad;norfilza binti mohd mokhtar;norlela binti sukor;tan geok chin;isa b mohamed rose.  (2019).  genetic study on aldosterone-producing adenomas (apas) in the multiethnic population of malaysia.  - 1-9. 

     

    junhua zhou, helen storr, emily cottrell, claudia cabrera, giulia argentesi, xilin wu, emily goodchild, elena azizan & morris j brown.  (2019).  double somatic mutations of ctnnb1 and gna11 in aldosterone producing adenomas (apas) presenting in puberty, pregnancy or menopause.  - endocrine abstracts.  75. 

     

    syahirah k. mohideen, muaatamarulain mustangin, nor azmi kamaruddin, rohaizak muhammad, rahman jamal, norlela sukor, geok c. tan and elena a. azizan.  (2019).  prevalence and histopathological characteristics of kcnj5 mutant aldosterone-producing adenomas in a multi-ethnic malaysian cohort.  - frontiers in endocrinology.  1-10. 

     

    noorasyikin ma, elena aa, teh pc, farah waheeda t, siti hajar md, long kc, norlinah mi.  (2020).  oral trehalose maybe helpful for patients with spinocerebellar ataxia 3 and should be better evaluated.  - parkinsonism and related disorders.  42-44. 

     

    syahirah k. mohideen, muaatamarulain mustangin, nor azmi kamaruddin, rohaizak muhammad, rahman jamal, norlela sukor, geok c. tan and elena a. azizan.  (2019).  prevalence and histopathological characteristics of kcnj5 mutant aldosterone-producing adenomas in a multi-ethnic malaysian cohort.  - frontiers in endocrinology.  1-10. 

     

    geok chin tan, giulia negro, alexandra pinggera, nur maya sabrina tizen laim, isa mohamed rose, jiri ceral, ales ryska, long kha chin, nor azmi kamaruddin, norfilza mohd mokhtar, a. rahman a. jamal, norlela sukor, miroslav solar, joerg striessnig, morris.  (2017).  aldosterone-producing adenomas: histopathology-genotype correlation and identification of a novel cacna1d mutation.  - hypertension.  129-136. 

     

    elena ab azizan, morris j brown.  (2016).  novel genetic determinants of adrenal aldosterone regulation.  - current opinion endocrinology, diabetes and obesity.  209-217. 

     

    catherine b xie, lalarukh haris shaikh, sumedha garg, gizem tanriver, ada ed teo, junhua zhou, carmela maniero, wanfeng zhao, soosung kang, richard b silverman, elena ab azizan, morris j brown.  (2016).  regulation of aldosterone secretion by cav1.3.  - scientific reports.  1-10. 

     

    s. jayakumar, elena azizan, shamsul azhar shah, arbaiyah bain & abdul halim abdul gafor.  (2020).  vitamin k status in diabetic patients with chronic kidney disease stage 3-5 and its effects on chronic kidney disease - mineral bone disorder.  - sains malaysiana.  613-624. 

     

    afifah binti azam, elena aisha binti azizan.  (2018).  brief overview of a decade of genome-wide association studies on primary hypertension.  - international journal of endocrinology.  1-14. 

     

    a.e.d. teo, s. garg, l. haris shaikh, j. zhou, f.e. karet frankl, m. gurnell, l. happerfield, a. marker, m. bienz, e.a.b. azizan, m.j. brown.  (2016).  effect of somatic ctnnb1 mutations on adrenocortical cell de-differentiation in adenoma presenting in early pregnancy or menopause.  - annales d`endocrinologie.  161-162. 

     

    elena ab azizan, morris j brown.  (2015).  the genetics of primary aldosteronism.  - journal of endocrinology and metabolism.  19-30. 

     

    elena aisha binti azizan;nor azmi bin kamaruddin;a. rahman bin a. jamal;norlela binti sukor;tan geok chin.  (2019).  pilot genome wide association study (gwas) of primary aldosteronism.  - 1-7. 

     

    elena aisha binti azizan;nor azmi bin kamaruddin;a. rahman bin a. jamal;rohaizak bin muhammad;norfilza binti mohd mokhtar;norlela binti sukor;tan geok chin;isa b mohamed rose.  (2019).  genetic study on aldosterone-producing adenomas (apas) in the multiethnic population of malaysia.  - 1-9. 

     

    syahirah kaja mohideen, a rahman a jamal, nor azmi kamaruddin, norlela sukor, elena aisha azizan.  (2017).  a pilot genome wide association study (gwas) in multi ethnic population of malaysia.  - 13th asian-pacific congress of hypertension. 

     

    syahirah kaja mohideen, a rahman a jamal, nor azmi kamaruddin, norlela sukor, elena aisha azizan.  (2017).  a pilot genome wide association study (gwas) on primary aldosteronism (pa) in multiethnic population of malaysia.  - the 8th malaysian endocrine and metabolic society annual congress. 

     

    junhua zhou, brian yh lam, sudeshna g neogi, giles sh yeo, ada ed teo, carmela maniero, wanfeng zhao, elena ab azizan, morris j brown.  (2016).  lessons from the comparison of the transcriptome profile of the autonomous aldosterone-producing tissue the aldosterone-producing adenoma and the physiological aldosterone-producing tissue the zona gl.  - endocrine society`s 98th annual meeting and expo. 

     
    Projek Tempoh Peranan
    associations of the susceptibility gene loci of systemic lupus erythematosus (sle) with renal manifestations and their functional proteins 01-08-202031-07-2022 Penyelidik Bersama
    associations of the malaysian susceptibility gene loci of systemic lupus erythematosus (sle) with lupus nephritis and treatment response 11-06-202010-12-2021 Penyelidik Bersama
    a pilot study assessing angiotensin‐converting enzyme ii (ace2) expression in the in fectivity and severity of covid-19 15-05-202014-05-2022 Ketua Projek
    (Tiada Rekod Tajuk) 07-04-202006-04-2022 Ketua Projek
    (Tiada Rekod Tajuk) 10-03-2020 Penyelia
    discerning the genetic contributors to autonomous aldosterone production through whole genome sequencing 01-01-202031-03-2023 Ketua Projek
    elucidating the role of aldosterone production on cell proliferation and apoptosis 28-11-201927-11-2022 Ketua Projek
    discerning a biomarker for complete cure of hypertension post-adrenalectomy among primary aldosteronism patients 01-09-201930-11-2022 Ketua Projek
    identification of putative protein profiles associated with tamoxifen therapy effectiveness in residual non-functioning pituitary neuroendocrine tumors 30-03-201929-03-2021 Penyelidik Bersama
    associations of the common susceptibility risk loci of sytemic lupus erythematosus (sle) with disease manifestations and treatment response. 01-01-201931-03-2021 Penyelidik Bersama
    vitamin k status in diabetic chronic kidney disease stage 3-5 and the effects of vitamin k replacement on bone markers in malaysian population 27-09-201826-03-2020 Penyelidik Bersama
    association of single nucleotide polymorphisms of cyp11b2, cyp11b1 and cyp17a1 with primary aldosteronism in a multiethic malaysian cohort 10-05-201809-11-2019 Ketua Projek
    advancing care of adrenal disease and adrenal registry in asia (adrenal asia) 29-03-201828-06-2020 Penyelidik Bersama
    clinical effects of oral trehalose in patients with spinocerebellar ataxia 3 : a pilot study 07-03-201805-05-2020 Penyelidik Bersama
    the role of selectively expressed zona glomerulosa (zg) genes on aldosterone and cell function in physiological and pathological adaptation to salt excess 11-01-201830-09-2021 Ketua Projek
    pilot genome wide association study (gwas) of primary aldosteronism 01-01-201731-12-2018 Ketua Projek
    pilot genome wide association study (gwas) on primary aldosteronism in the multiethnic population of malaysia 11-08-201610-08-2018 Ketua Projek
    development of a genetic screening method for polyglutamine expansion spinocerebellar ataxias in the national university of malaysia medical centre 19-06-201618-12-2016 Ketua Projek
    ganjaran penerbitan: elena aisha binti azizan 01-05-201630-04-2018 Ketua Projek
    histopathological-specific mutation spectrum of primary aldosteronism in ukmmc 28-04-201627-04-2019 Ketua Projek
    genetic study on aldosterone-producing adenomas (apas) in the multiethnic population of malaysia 02-11-201501-10-2018 Ketua Projek
    exome sequencing for somatic mutations in aldosterone-producing adenomas 01-06-201531-05-2016 Ketua Projek
    the genetics of adrenal gland diseases causing hyoertension 01-05-201530-04-2018 Ketua Projek
    thyroid disorders in malaysia : a nationwide multicentre study 26-06-201425-06-2016 Penyelidik Bersama
    primary aldosteronism in malaysia : a nation-wide multicentre study 24-04-201423-04-2019 Penyelidik Bersama