prof. madya dr. elena aisha binti azizan

pensyarah universiti

jabatan perubatan

No. rasmi:
UKM : 03 8921 5555



   Biografi/ Biography :

  • My research career officially started with my PhD at the University of Cambridge, UK, under the supervision of Prof Morris J Brown in 2008-2012. There I developed my interest in the disease primary aldosteronism, a common cause for curable secondary hypertension. Upon completion of my PhD, I continued as a research associate with Prof Morris J Brown’s group until the end of 2013, before starting my career here at the National University of Malaysia (UKM) Medical Center. During my period in Cambridge, we managed to characterize the genetics and histology of adenomas causing primary aldosteronism into two groups – those that were similar to the outer layer of the adrenal cortex (the zona glomerulosa) and those that were similar to the middle layer of the adrenal cortex (the zona fasciculata). The findings were presented at several international scientific meetings which led to the attainment of the Austin Doyle (Servier) Award at the 24th International Scientific Meeting of the International Hypertension (ISH) in Sydney, Australia, and the Young Investigator Award at the 39th International Aldosterone Conference in San Francisco, USA. As hypertension affects at least one third of adults in Malaysia, research on primary aldosteronism is essential to be continued in Malaysia. Hence, I am still continuing my research on primary aldosteronism locally here in Malaysia in addition to focusing on the cell-fate/cell function of the zona glomerulosa in the adrenal glands through international collaborations with my PhD supervisor Prof Morris J Brown and co-investigators during my time in Cambridge. This has led to the recognition of the research locally in Malaysia as highlighted by the ASEAN Federation of Endocrine Societies (AFES) Investigator Award received in 2015 and the Young Investigator Award (Basic Science) received during the Malaysian Endocrine & Metabolic Society 8th Annual Congress (MAC8) in 2017.

  • syahrul sazliyana binti shaharir;a. rahman bin a. jamal;zarina binti abdul latiff;abdul halim bin abdul gafor;mohd shahrir bin mohamed said;nor azian binti abdul murad;tan geok chin;sakthiswary a/p rajalingham;noraidatulakma binti abdullah @ muda;ruslinda.  (2022).  associations of the common susceptibility risk loci of sytemic lupus erythematosus (sle) with disease manifestations and treatment response. .  -

     

    siti khadijah syed mohammed nazri, elena aisha azizan.  (2022).  hipertensi sekunder: gen-gen yang merangsang perembesan aldosteron yang berlebihan.  - jurnal sains kesihatan malaysia.  51-63. 

     

    abdul khalif adha abd talib, syahrul sazliyana shaharir, nor azian abdul murad, noraidatulakma abdullah, elena aisha azizan, abdul halim abdul gafor, ruslinda mustafar, mohd shahrir mohamed said, sakthiswary rajalingham, abdul rahmaa. jamal, zarina abdul.  (2022).  validation of the sle susceptible gene loci in the multi-ethnic malaysian systemic lupus erythematosus (sle) cohort and their associations with clinical manifestation.  - annals of the rheumatic diseases.  453. 

     

    sk syed mohammed nazri, r zakaria, n sukor, ea azizan.  (2021).  retrospective analysis of adrenal vein sampling (avs) success: a study of a malaysian cohort from a single tertiary center.  - journal of the asean federation of endocrine societies.  37. 

     

    siti khadijah syed mohammed nazri, elena aisha azizan.  (2021).  somatic mutations in primary aldosteronism - the most common cause for secondary hypertension.  - malaysian journal of human genetics.  13-24. 

     

    abdul khalif adha abd talib, syahrul sazliyana shaharir, nor azian abdul murad, noraidatulakma abdullah, elena aisha azizan, abdul halim abdul gafor, ruslinda mustafar, mohd shahrir mohamed said, sakthiswary rajalingham, abdul rahmaa. jamal, zarina abdul.  (2022).  validation of the sle susceptible gene loci in the multi-ethnic malaysian systemic lupus erythematosus (sle) cohort and their associations with clinical manifestation.  - annals of the rheumatic diseases.  453. 

     

    fatin athirah pauzi and elena aisha azizan.  (2021).  functional characteristic and significance of aldosterone-producing cell clusters in primary aldosteronism and age-related hypertension.  - frontiers in endocrinology.  1-7. 

     

    junhua zhou, elena a b azizan, claudia p cabrera, fabio l fernandes-rosa, sheerazed boulkroun, giulia argentesi, emily cottrell, laurence amar, xilin wu, sam o'toole, emily goodchild, alison marker, russel.  (2021).  somatic mutations of gna11 and gnaq in ctnnb1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause.  - nature genetics.  1360-1372. 

     

    noorasyikin ma, elena aa, teh pc, farah waheeda t, siti hajar md, long kc, norlinah mi.  (2020).  oral trehalose maybe helpful for patients with spinocerebellar ataxia 3 and should be better evaluated.  - parkinsonism and related disorders.  42-44. 

     

    syahirah k. mohideen, muaatamarulain mustangin, nor azmi kamaruddin, rohaizak muhammad, rahman jamal, norlela sukor, geok c. tan and elena a. azizan.  (2019).  prevalence and histopathological characteristics of kcnj5 mutant aldosterone-producing adenomas in a multi-ethnic malaysian cohort.  - frontiers in endocrinology.  1-10. 

     

    giulia argentesi, junhua zhou, elena azizan, claudia p cabrera, emily cottrell, xilin wu, emily goodchild, roger foo, chaz mein, eva wozniak, william drake, helen storr, morris brown.  (2021).  aldosterone-producing adenomas with dual mutations of gna11/q and ctnnb1 lead to hypertension in puberty, pregnancy or menopause, and complete cure by adrenalectomy.  - journal of human hypertension.  5. 

     

    noor syazwani izyan a, abdul khalif adha, elena aisha azizan, nor azian abdul murad, noraidatulakma abdullah, mohd shahrir mohamed said, ruslinda mustafar, abdul halim abdul gafor, zarina abdul latiff, syahrul sazliyana.  (2021).  associations of the malaysian susceptibility gene loci of systemic lupus erythematosus (sle) with lupus nephritis and treatment response.  - international journal of rheumatic diseases.  308-309. 

     

    elena azizan, morris brown.  (2020).  ace2 role in sars-cov-2 infectivity and covid-19 severity.  - malaysian journal of pathology.  1-6. 

     

    s. jayakumar, elena azizan, shamsul azhar shah, arbaiyah bain & abdul halim abdul gafor.  (2020).  vitamin k status in diabetic patients with chronic kidney disease stage 3-5 and its effects on chronic kidney disease - mineral bone disorder.  - sains malaysiana.  613-624. 

     

    afifah binti azam, elena aisha binti azizan.  (2018).  brief overview of a decade of genome-wide association studies on primary hypertension.  - international journal of endocrinology.  1-14. 

     

    abdul khalif adha abd talib, syahrul sazliyana shaharir, nor azian abdul murad, noraidatulakma abdullah, elena aisha azizan, abdul halim abdul gafor, ruslinda mustafar, mohd shahrir mohamed said, sakthiswary rajalingham, abdul rahmaa. jamal, zarina abdul.  (2022).  validation of the sle susceptible gene loci in the multi-ethnic malaysian systemic lupus erythematosus (sle) cohort and their associations with clinical manifestation.  - annals of the rheumatic diseases.  453. 

     

    sk syed mohammed nazri, r zakaria, n sukor, ea azizan.  (2021).  retrospective analysis of adrenal vein sampling (avs) success: a study of a malaysian cohort from a single tertiary center.  - journal of the asean federation of endocrine societies.  37. 

     

    giulia argentesi, junhua zhou, elena azizan, claudia p cabrera, emily cottrell, xilin wu, emily goodchild, roger foo, chaz mein, eva wozniak, william drake, helen storr, morris brown.  (2021).  aldosterone-producing adenomas with dual mutations of gna11/q and ctnnb1 lead to hypertension in puberty, pregnancy or menopause, and complete cure by adrenalectomy.  - journal of human hypertension.  5. 

     

    abdul khalif adha abd talib, shing cheng tan, rahman jamal, elena aisha azizan, syahrul sazliyana shaharir, nor azian abdul murad.  (2021).  associated genetic polymorphisms and clinical manifestations in systemic lupus erythematosus in asian populations - a systematic literature review.  - medical journal of malaysia.  541-550. 

     

    fatin athirah pauzi and elena aisha azizan.  (2021).  functional characteristic and significance of aldosterone-producing cell clusters in primary aldosteronism and age-related hypertension.  - frontiers in endocrinology.  1-7. 

     

    syahrul sazliyana binti shaharir;a. rahman bin a. jamal;zarina binti abdul latiff;abdul halim bin abdul gafor;mohd shahrir bin mohamed said;nor azian binti abdul murad;tan geok chin;sakthiswary a/p rajalingham;noraidatulakma binti abdullah @ muda;ruslinda.  (2022).  associations of the common susceptibility risk loci of sytemic lupus erythematosus (sle) with disease manifestations and treatment response. .  -

     

    norlaila mustafa, zarina abdul latiff, alfizah hanafiah, salwati shuib, teoh seong lin, yogeswaran lokanathan, elena aisha azizan, mohd helmy mokhtar, tan jen kit.  (2021).  student guidebook for master in medical science and doctor of philosophy programmes (research mode) faculty of medicine ukm.  - 1-42. 

     

    norlaila mustafa, zarina abdul latiff, alfizah hanafiah, salwati shuib, teoh seong lin, yogeswaran lokanathan, elena aisha azizan, mohd helmy mokhtar, tan jen kit, raja muhammad azlan shah raja alang m, nurul safaniza che ani.  (2021).  buku panduan pelajar program sarjana sains perubatan dan doktor falsafah (mod penyelidikan) fakulti perubatan universiti kebangsaan malaysia (ukm).  - 1-43. 

     

    elena ab azizan.  (2021).  syor pembedahan kelenjar adrenal.  - harian metro.  40. 

     

    elena ab azizan, norlela b sukor.  (2021).  berpotensi pulih sepenuhnya.  - metro.  38.