dr. elena aisha binti azizan

pensyarah universiti

jabatan perubatan

 elena.azizan@ukm.edu.my

No. rasmi:
UKM : 03 8921 5555



   Biografi/ Biography :

  • My research career officially started with my PhD at the University of Cambridge, UK, under the supervision of Prof Morris J Brown in 2008-2012. There I developed my interest in the disease primary aldosteronism, a common cause for curable secondary hypertension. Upon completion of my PhD, I continued as a research associate with Prof Morris J Brown’s group until the end of 2013, before starting my career here at the National University of Malaysia (UKM) Medical Center. During my period in Cambridge, we managed to characterize the genetics and histology of adenomas causing primary aldosteronism into two groups – those that were similar to the outer layer of the adrenal cortex (the zona glomerulosa) and those that were similar to the middle layer of the adrenal cortex (the zona fasciculata). The findings were presented at several international scientific meetings which led to the attainment of the Austin Doyle (Servier) Award at the 24th International Scientific Meeting of the International Hypertension (ISH) in Sydney, Australia, and the Young Investigator Award at the 39th International Aldosterone Conference in San Francisco, USA. As hypertension affects at least one third of adults in Malaysia, research on primary aldosteronism is essential to be continued in Malaysia. Hence, I am still continuing my research on primary aldosteronism locally here in Malaysia in addition to focusing on the cell-fate/cell function of the zona glomerulosa in the adrenal glands through international collaborations with my PhD supervisor Prof Morris J Brown and co-investigators during my time in Cambridge. This has led to the recognition of the research locally in Malaysia as highlighted by the ASEAN Federation of Endocrine Societies (AFES) Investigator Award received in 2015 and the Young Investigator Award (Basic Science) received during the Malaysian Endocrine & Metabolic Society 8th Annual Congress (MAC8) in 2017.

  • elena ab azizan, junhua zhou, claudia p cabrera, fabio luiz fernandes-rosa, sheerazed boulkroun, giulia argentesi, emily cottrell, laurence amar, xilin wu, alison marker, sumedha garg, tobias akerstrom, samuel backman, suzanne jordan, et al.  (2021).  somatic mutations of gna11 and gnaq in ctnnb1-mutant aldosterone-producing adenomas increases aldosterone and aldosterone synthase (cyp11b2).  - journal of the endocrine society.  A72. 

     

    elena ab azizan, norlela b sukor.  (2021).  berpotensi pulih sepenuhnya.  - metro.  38. 

     

    fatin athirah pauzi and elena aisha azizan.  (2021).  functional characteristic and significance of aldosterone-producing cell clusters in primary aldosteronism and age-related hypertension.  - frontiers in endocrinology.  1-7. 

     

    abdul khalif adha abd talib, shing cheng tan, rahman jamal, elena aisha azizan, syahrul sazliyana shaharir, nor azian abdul murad.  (2021).  associated genetic polymorphisms and clinical manifestations in systemic lupus erythematosus in asian populations - a systematic literature review.  - medical journal of malaysia.  541-550. 

     

    elena ab azizan, mohammad arif shahar, siti liyana saud ghany, a rahman a jamal, nor azmi kamaruddin, norasyikin a wahab, ahmad marzuki omar, chin voon tong, azraai nasruddin, norlela sukor, morris jonathan brown, syahirah kaja mohideen.  (2020).  a pilot genome wide association study (gwas) on primary aldosteronism patients in a multi-ethnic malaysian cohort.  - journal of the endocrine society.  A1021. 

     

    fatin athirah pauzi and elena aisha azizan.  (2021).  functional characteristic and significance of aldosterone-producing cell clusters in primary aldosteronism and age-related hypertension.  - frontiers in endocrinology.  1-7. 

     

    noorasyikin ma, elena aa, teh pc, farah waheeda t, siti hajar md, long kc, norlinah mi.  (2020).  oral trehalose maybe helpful for patients with spinocerebellar ataxia 3 and should be better evaluated.  - parkinsonism and related disorders.  42-44. 

     

    syahirah k. mohideen, muaatamarulain mustangin, nor azmi kamaruddin, rohaizak muhammad, rahman jamal, norlela sukor, geok c. tan and elena a. azizan.  (2019).  prevalence and histopathological characteristics of kcnj5 mutant aldosterone-producing adenomas in a multi-ethnic malaysian cohort.  - frontiers in endocrinology.  1-10. 

     

    geok chin tan, giulia negro, alexandra pinggera, nur maya sabrina tizen laim, isa mohamed rose, jiri ceral, ales ryska, long kha chin, nor azmi kamaruddin, norfilza mohd mokhtar, a. rahman a. jamal, norlela sukor, miroslav solar, joerg striessnig, morris.  (2017).  aldosterone-producing adenomas: histopathology-genotype correlation and identification of a novel cacna1d mutation.  - hypertension.  129-136. 

     

    azizan e, sukor n, kamaruddin na, jamal ar, ceral j, solar m, rose im, tan gc.  (2016).  histopathological-specific mutation spectrum of aldosterone-producing adenomas.  - journal of hypertension.  e550. 

     

    elena azizan, morris brown.  (2020).  ace2 role in sars-cov-2 infectivity and covid-19 severity.  - malaysian journal of pathology.  1-6. 

     

    s. jayakumar, elena azizan, shamsul azhar shah, arbaiyah bain & abdul halim abdul gafor.  (2020).  vitamin k status in diabetic patients with chronic kidney disease stage 3-5 and its effects on chronic kidney disease - mineral bone disorder.  - sains malaysiana.  613-624. 

     

    afifah binti azam, elena aisha binti azizan.  (2018).  brief overview of a decade of genome-wide association studies on primary hypertension.  - international journal of endocrinology.  1-14. 

     

    a.e.d. teo, s. garg, l. haris shaikh, j. zhou, f.e. karet frankl, m. gurnell, l. happerfield, a. marker, m. bienz, e.a.b. azizan, m.j. brown.  (2016).  effect of somatic ctnnb1 mutations on adrenocortical cell de-differentiation in adenoma presenting in early pregnancy or menopause.  - annales d`endocrinologie.  161-162. 

     

    elena ab azizan, morris j brown.  (2015).  the genetics of primary aldosteronism.  - journal of endocrinology and metabolism.  19-30. 

     

    elena ab azizan, norlela b sukor.  (2021).  berpotensi pulih sepenuhnya.  - metro.  38. 

     

    elena aisha binti azizan.  (2020).  ace2: kawan atau lawan sars2, covid-19.  - metro ahad.  37-38. 

     

    elena azizan, norlela sukor, morris brown.  (2020).  ace2: rakan atau musuh covid-19?.  - the malaysian medical gazette.  1-12. 

     

    elena aisha binti azizan;nor azmi bin kamaruddin;a. rahman bin a. jamal;norlela binti sukor;tan geok chin.  (2019).  pilot genome wide association study (gwas) of primary aldosteronism.  - 1-7. 

     

    elena aisha binti azizan;nor azmi bin kamaruddin;a. rahman bin a. jamal;rohaizak bin muhammad;norfilza binti mohd mokhtar;norlela binti sukor;tan geok chin;isa b mohamed rose.  (2019).  genetic study on aldosterone-producing adenomas (apas) in the multiethnic population of malaysia.  - 1-9.