pensyarah universiti
institut biologi molekul perubatan ukm (umbi)
effendisy@ppukm.ukm.edu.my
No. Telefon Rasmi : 0391459072
No. rasmi:
UKM : 03 8921 5555
Biografi/ Biography :
Saiful Effendi Syafruddin is a Research Fellow/Senior Lecturer at the UKM Medical Molecular Biology Institute (UMBI). He holds PhD in Medical Sciences from the University of Cambridge, UK. He previously earned his Master’s in Biotechnology (Molecular Genetic) from the University of Pennsylvania, USA, and BSc. in Biotechnology from Rochester Institute of Technology, USA. His PhD project focused on elucidating the genetic and epigenetic determinants that support kidney cancer pathogenesis. Saiful Effendi research interest revolves around understanding cancer molecular dependencies, specifically in kidney cancer, with the aim to identify novel and efficient clinical strategies to fight against cancer. Having been trained in the field of cell and molecular biology, cancer biology and genetic engineering for more than a decade, he has been extensively utilizing various state-of-the-art laboratory techniques throughout his cancer research works. Several of his research works have been published in high impact journals such as Nature, Cancer Discovery, Nature Communication, and Cell.
asmaa y. abuhamad, nurul nadia mohamad zamberi, sakari vanharanta, siti nur hasanah mohd yusuf, m. aiman mohtar, saiful effendi syafruddin. (2023). cancer cell-derived pdgfb stimulates mtorc1 activation in renal carcinoma. - international journal of molecular sciences. 1-14.
kim jun cheng, elsa hanifah mejia mohamed, saiful effendi syafruddin, zaridatul aini ibrahim. (2023). interleukin-1 alpha and high mobility group box-1 secretion in olyinosinic: polycytidylic-induced colorectal cancer cells occur via ripk1-dependent mechanism and participate in tumourigenesis. - journal of cell communication and signaling. 189-208.
poh kuan wong, nurul nadia mohamad zamberi, saiful effendi syafruddin, fook choe cheah, norazrina azmi, jia xian law, eng wee chua. (2023). the promises and pitfalls of crispr-mediated base editing in stem cells. - crispr journal. 196-215.
marjanu hikmah elias, nurunnajah lazim, zulazmi sutaji, mohammad azrai abu, abdul kadir abdul karim, azizah ugusman, saiful effendi syafruddin, mohd helmy mokhtar, mohd faizal ahmad. (2023). hoxa10 dna methylation level in the endometrium women with endometriosis: a systematic review. - biology. 1-11.
nur syakirah othman, amilia aminuddin, shahidee zainal abidin, saiful effendi syafruddin, mohd faizal ahmad, norfilza mohd mokhtar, jaya kumar, adila a. hamid, azizah ugusman. (2023). profiling of differentially expressed micrornas in human umbilical vein endothelial cells exposed to hyperglycemia via rna sequencing. - life. 1-16.
kim jun cheng, elsa hanifah mejia mohamed, saiful effendi syafruddin, zaridatul aini ibrahim. (2023). interleukin-1 alpha and high mobility group box-1 secretion in olyinosinic: polycytidylic-induced colorectal cancer cells occur via ripk1-dependent mechanism and participate in tumourigenesis. - journal of cell communication and signaling. 189-208.
marjanu hikmah elias, nurunnajah lazim, zulazmi sutaji, mohammad azrai abu, abdul kadir abdul karim, azizah ugusman, saiful effendi syafruddin, mohd helmy mokhtar, mohd faizal ahmad. (2023). hoxa10 dna methylation level in the endometrium women with endometriosis: a systematic review. - biology. 1-11.
nur syakirah othman, amilia aminuddin, shahidee zainal abidin, saiful effendi syafruddin, mohd faizal ahmad, norfilza mohd mokhtar, jaya kumar, adila a. hamid, azizah ugusman. (2023). profiling of differentially expressed micrornas in human umbilical vein endothelial cells exposed to hyperglycemia via rna sequencing. - life. 1-16.
syazalina zahari, saiful effendi syafruddin and m. aiman mohtar. (2023). impact of the cancer cell secretome in driving breast cancer progression. - cancers. 1-17.
ryia illani my, nurul-syakima am, jia-shiun k, sazuita s, muhiddin i, saiful effendi s, francis yew ft, najwa farhah my, mohd ridhwan ar, norshahidah mn, nadiah a, isa md rose, ismail sagap, luqman mazlan, rahman jamal. (2023). whole genome sequencing of malaysian colorectal cancer patients reveals specific druggable somatic mutations. - frontiers in molecular biosciences. 1-20.
saiful effendi syafruddin, wan fahmi wan mohamad nazarie, nurshahirah ashikin moidu, bee hong soon, m. aiman mohtar. (2021). integration of rna-seq and proteomics data identifies glioblastoma multiforme surfaceome signature. - bmc cancer. 1-13.
nur fadhlina mohamad pakarulrazy, saiful effendi syafruddin, nurul syakima ab mutalib, azlina ahmad annuar, shen yang lim, rahman jamal, nor azian abdul murad, norlinah mohamed ibrahim. (2020). glucocerebrosidase genetic variants in malays with early and late-onset parkinson's disease. - neurology asia. 39-46.
asmaa y. abuhamad, nurul nadia mohamad zamberi, sakari vanharanta, siti nur hasanah mohd yusuf, m. aiman mohtar, saiful effendi syafruddin. (2023). cancer cell-derived pdgfb stimulates mtorc1 activation in renal carcinoma. - international journal of molecular sciences. 1-14.
marjanu hikmah elias, nurunnajah lazim, zulazmi sutaji, mohammad azrai abu, abdul kadir abdul karim, azizah ugusman, saiful effendi syafruddin, mohd helmy mokhtar, mohd faizal ahmad. (2023). hoxa10 dna methylation level in the endometrium women with endometriosis: a systematic review. - biology. 1-11.
nur syakirah othman, amilia aminuddin, shahidee zainal abidin, saiful effendi syafruddin, mohd faizal ahmad, norfilza mohd mokhtar, jaya kumar, adila a. hamid, azizah ugusman. (2023). profiling of differentially expressed micrornas in human umbilical vein endothelial cells exposed to hyperglycemia via rna sequencing. - life. 1-16.
syazalina zahari, saiful effendi syafruddin and m. aiman mohtar. (2023). impact of the cancer cell secretome in driving breast cancer progression. - cancers. 1-17.
ryia illani my, nurul-syakima am, jia-shiun k, sazuita s, muhiddin i, saiful effendi s, francis yew ft, najwa farhah my, mohd ridhwan ar, norshahidah mn, nadiah a, isa md rose, ismail sagap, luqman mazlan, rahman jamal. (2023). whole genome sequencing of malaysian colorectal cancer patients reveals specific druggable somatic mutations. - frontiers in molecular biosciences. 1-20.
saiful effendi syafruddin, mohamad aimanuddin mohtar, tan shing cheng, nadiah abu, nor aidatulakma abdullah@muda, nurul syakima ab mutalib, chin siok fong, neoh hui min, rahman jamal, nor azian abdul murad. (2019). malaysian higher institution centres of excellence (hicoe) official compendium. - . 244.
saiful effendi syafruddin, nurul nadia mohamad zamberi, asmaa y. abuhamad. sarah izzati izzat azrai, mohd khairul nizam mohd khalid , m. aiman mohtar. (2023). super enhancer-associated glucocorticoid receptor nr3c1 supports renal carcinoma growth by transcriptionally regulating the expression of pdk4, edn2 and il-6. - 15th malaysia international genetics congress 2023. 1-19.
ahmad rifqi bin md zain;tengku hasnan bin tengku abdul aziz;saiful effendi bin syafruddin;mohamad aimanuddin bin mohtar. (2023). optical sensor technique based on high quality factor suspended 1d photonic crystal (phc) structures for creatinine detection using non-invasive approach.. - . .
saiful effendi bin syafruddin;muhiddin bin ishak;mohamad aimanuddin bin mohtar;low teck yew. (2023). functional validation of crispr-cas9 genetic screening hit hsf4 in supporting clear cell renal cell carcinoma pathogenesis. - . .
low teck yew;mohd firdaus bin mohd raih;saiful effendi bin syafruddin;mohamad aimanuddin bin mohtar;lee pey yee. (2022). elucidating the mechanism of secretion for human pro-metastatic agr2 protein. - . .
nurainie sayutti, muhammad azrai abu, saiful effendi, mohd faizal ahmad. (2022). elucidating the gene expression of grem 1 in cumulus cells and its association with oocytes quality in predicting pregnancy outcomes among pcos women. - gynecological endocrinology the 20th world congress. 1.
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| ELUCIDATING THE GREM1, HAS2 AND PTGS2 GENE EXPRESSION AS OOCYTES DEVELOPMENT COMPETENCY MARKERS AMONG WOMEN WITH POOR OVARIAN RESERVE (POR) FOLLOWING THE IN VITRO MATURATION (IVM) | haczen sdn. bhd | 58.6% (2021-09-07 sehingga 2024-09-06) |
| ELUCIDATING THE MICROPROTEOME UNIQUELY EXPRESSED IN CELL LINES DERIVED FROM MULTIPLE STAGES OF COLORECTAL CANCER (CRC) | sciex | 95.4% (2020-08-01 sehingga 2023-07-31) |
| COMB STRUCTURED WEARABLE METAMATERIAL WITH ELECTRICAL CONDUCTIVITY FOR HEALTH MONITORING GARMENT OF SEVERE PATIENTS | kelisa technology sdn bhd | 88.9% (2021-09-01 sehingga 2023-08-31) |
| ELUCIDATING THE FUNCTIONAL LINK BETWEEN PROXIMAL SUPER ENHANCER LOCUS AND NR3C1 TRANSCRIPTIONAL REGULATION IN CLEAR CELL RENAL CELL CARCINOMA. | next gene scientific sdn bhd | 76.1% (2021-03-01 sehingga 2024-02-28) |