pensyarah universiti
institut biologi molekul perubatan ukm (umbi)
effendisy@ppukm.ukm.edu.my
Kesihatan dan Perubatan Termaju,
Dr. Saiful holds a PhD in Medical Sciences from the University of Cambridge, a Master in Biotechnology (Molecular Genetics) from the University of Pennsylvania and a BSc in Biotechnology from the Rochester Institute of Technology. Dr. Saiful’s primary research focuses on decoding cancer molecular dependencies, particularly in kidney cancer, with the ultimate goal of developing novel, efficient clinical strategies to combat the disease. His high-impact research contributions have been widely published in leading scientific journals, including Nature, Cancer Discovery, Nature Communications and eBiomedicine.
As a recognized expert in CRISPR gene-editing technology, he actively drives scientific capacity-building within Malaysia by designing and leading specialized workshops and professional certification programs. Beyond his research, Dr. Saiful lends his expertise to critical regulatory and advisory bodies globally and domestically. Nationally, he serves as a member of the Genetic Modification Advisory Committee under the Ministry of Natural Resources and Environmental Sustainability. Internationally, he represents the Asia-Pacific region as a member of the Technical Expert Group on Synthetic Biology for the United Nations Convention on Biological Diversity.
nur qurratu’ athirah a rahman, rahman jamal, ahmad suhail khazali, mohamad aimanuddin mohtar, saiful effendi syafruddin . (2026). dual targeting of hif-2a and klf6 suppresses angiogenic signaling in clear cell renal cell carcinoma (ccrcc). - 1st regional conference on precision health (rcph). .
haizatul umiyah nor azmi, shing cheng tan, nor azila muhammad azami, muhammad irfan abdul jalal, saiful effendi syafruddin, abdul kadir abdul karim, rahana abd rahman, chew kah teik, mohd faizal ahmad, nur azurah abdul ghani, muhammad azrai bin abu, rahman jamal. (2026). longitudinal shotgun metagenomic profiling of the vaginal microbiome in pregnant and non-pregnant malaysian women. - 1st regional confrerence on precision medicine. .
nurul nadia mohamad zamberi, asmaa y. abuhamad, siti nur hasanah mohd yusuf, nur qurratu athirah a. rahman, mohamad aimanuddin mohtar and saiful effendi syafruddin. (2026). perturbation of brd4 and p300 activity suppresses super enhancer-driven klf6 expression in renal carcinoma. - oncology reports. 1 - 13.
adila a hamid, nurul iffah mohd isa, amilia aminuddin, saiful effendi syafruddin, mohd faizal ahmad, mohd faizal ahmad?shahidee zainal abidin, azizah ugusman. (2026). modulation of inflammation-related genes by mir-196a-5p in endothelial cells from hypertensive pregnancies. - the annual meeting of the physiological society of japan. .
harouna issa amadou, onyeka nwosu, annah runesu takombwa, weiwen zhang, saiful effendi syafruddin, enkhchimeg vanjildorj, sirine shogheryan, galina mozgova, florian caspar rabitz, martin batic, maría florencia goberna, edian franklin franco de los santos, jocelyn cheé santiago, danilo fernández, kathleen lehmann, valeria giovannelli, margaret hunter, maria yolanda teran maigua, daphne esquivel-sada, zhaoqi ma, wei wei, emily aurand, ana atanassova, carolina torres trueba, ben novak, sarah zanon agapito, richard guy reeves, lim li ching. (2026). report of the ad hoc technical expert group on synthetic biology. - . .
chien fung chong, syafinaz amin nordin, saiful effendi syafruddin, nurul izza ismail, ana masara ahmad mokhtar. (2026). molecular and functional consequences of the cdc42 c81y mutation in immune-associated malignancy. - archives of biochemistry and biophysics. 1 - 13.
adila a hamid, nurul iffah mohd isa, amilia aminuddin, saiful effendi syafruddin, mohd faizal ahmad, shahidee zainal abidin, azizah ugusman. (2026). modulation of inflammation-related genes by mir 196a-5p in endothelial cells from hypertensive pregnancies. - the journal of physiological sciences. 280 - 280.
nurul nadia mohamad zamberi, asmaa y. abuhamad, siti nur hasanah mohd yusuf, nur qurratu athirah a. rahman, mohamad aimanuddin mohtar and saiful effendi syafruddin. (2026). perturbation of brd4 and p300 activity suppresses super enhancer-driven klf6 expression in renal carcinoma. - oncology reports. 1 - 13.
mohamad aimanuddin mohtar, yuh cai chia , saiful effendi syafruddin, muhammad-redha abdullah-zawawi, ted hupp, delphine fessart . (2026). dissecting the cis- and trans-regulatory architecture governing agr2 expression in estrogen receptor-positive breast cancer. - esmo open. 7 - 8.
m. aiman mohtar, siti nurmi nasir, zuraini abd razak, hanif zulkhairi mohamad said, syazalina zahari, saiful effendi syafruddin. (2026). rna-seq analysis reveals regulatory networks driven by epcam overexpression in esophageal adenocarcinoma cells. - peerj. 1 - 24.
muhammad bani yamin, fazleen haslinda mohd hatta , mohd shafiq aazmi, saiful effendi syafruddin, michelle yee shuen lee, nurul hanis ramzi ,nikman adli nor hashim and nazia abdul majid. (2025). unravelling putative ethnic-specific obesity genetic loci in malaysian youths: a genome-wide association study. - southeast asian journal of tropical medicine and public health. 253 - 290.
m. aiman mohtar, delphine fessart, chia yuh cai, syazalina zahari, saiful effendi syafruddin, muhammad-redha abdullah-zawawi, ted hupp. (2025). crispr-mediated agr2 repression reveals esr1-driven transcriptional control in breast cancer cells. - asia-pacific journal of clinical oncology. 6 - 6.
poh kuan wong, saiful effendi syafruddin, fook choe cheah, norazrina azmi, pei yuen ng, eng wee chua. (2024). introduction of a single-nucleotide variant, rs16851030, into the adora1 gene increased cellular susceptibility to hypoxia. - personalized medicine. 353 - 366.
kelly xue jing jong, elsa haniffah mejia mohamed, saiful effendi syafruddin, farid nazer faruqu, kumutha malar vellasamy, kamariah ibrahim, zaridatul aini ibrahim. (2024). il-8 and pi3k pathway influence the susceptibility of trail-sensitive colorectal cancer cells to trail-induced cell death. - molecular biology reports. 1 - 10.
mohd faizal ahmad, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu, saiful effendi syafruddin, ani amelia zainuddin, nao suzuki, shamsul azhar shah, abdul kadir abdul karim. (2024). gene expression profiling of hyaluronic acid synthetase 2 (has2), prostaglandin-endoperoxide synthase 2 (ptgs2) and gremlin 1 (grem1) in cumulus cells among women with diminished ovarian reserved (dor). - mjm vol 79 supplement 3, july 2024 . 7 - 7.
mohamad aimanuddin mohtar, yuh cai chia , saiful effendi syafruddin, muhammad-redha abdullah-zawawi, ted hupp, delphine fessart . (2026). dissecting the cis- and trans-regulatory architecture governing agr2 expression in estrogen receptor-positive breast cancer. - esmo open. 7 - 8.
m. aiman mohtar, siti nurmi nasir, zuraini abd razak, hanif zulkhairi mohamad said, syazalina zahari, saiful effendi syafruddin. (2026). rna-seq analysis reveals regulatory networks driven by epcam overexpression in esophageal adenocarcinoma cells. - peerj. 1 - 24.
nurul nadia mohamad zamberi, asmaa y. abuhamad, siti nur hasanah mohd yusuf, nur qurratu athirah a. rahman, mohamad aimanuddin mohtar and saiful effendi syafruddin. (2026). perturbation of brd4 and p300 activity suppresses super enhancer-driven klf6 expression in renal carcinoma. - oncology reports. 1 - 13.
chien fung chong, syafinaz amin nordin, saiful effendi syafruddin, nurul izza ismail, ana masara ahmad mokhtar. (2026). molecular and functional consequences of the cdc42 c81y mutation in immune-associated malignancy. - archives of biochemistry and biophysics. 1 - 13.
adila a hamid, nurul iffah mohd isa, amilia aminuddin, saiful effendi syafruddin, mohd faizal ahmad, shahidee zainal abidin, azizah ugusman. (2026). modulation of inflammation-related genes by mir 196a-5p in endothelial cells from hypertensive pregnancies. - the journal of physiological sciences. 280 - 280.
m. aiman mohtar, saiful effendi syafruddin, muhammad-redha abdullah-zawawi, muhammad irfan abdul jalal, teck yew low, shing cheng tan. (2026). integrated approach to precision oncology. - interdisciplinary cancer research. 407 - 427.
muhammad-redha abdullah-zawawi, shing cheng tan, m. aiman mohtar, saiful effendi syafruddin, teck yew low, muhammad irfan abdul jalal. (2025). unveiling cancer complexity: machine learning insights into multi-omics data. - . 51 - 69.
aminah suhaila haron, saiful e. syafruddin, ilie fadzilah hashim, muggunna balasubramaniam, saw keat chuan, yasmin hasnizan, nurul syafawani fizal, chong chien fung, ana masara ahmad mokhtar. (2023). genetic mutations and clinical diagnoses associated with increased risk of malignancy in primary immunodeficiencies. - . 235-251.
saiful effendi syafruddin, mohamad aimanuddin mohtar, tan shing cheng, nadiah abu, nor aidatulakma abdullah@muda, nurul syakima ab mutalib, chin siok fong, neoh hui min, rahman jamal, nor azian abdul murad. (2019). umbi initiatives on colorectal cancer biomarkers discovery. - . 19-28.
chia yuh cai, saiful effendi syafruddin, m. aiman mohtar. (2026). strategi terapeutik berasaskan crispr: sempadan baru dalam rawatan kanser payudara. - jurnal sains kesihatan malaysia. 92 - 105.
nurul nadia mohamad zamberi, mohd raziff alias, m. aiman mohtar, saiful effendi syafruddin. (2025). aplikasi teknologi crispr/cas9 dan penyuntingan perdana dalam kajian biologi molekul dan kefungsian gen. - jurnal sains kesihatan malaysia. 67 - 79.
azizan baharuddin, noor munirah isa, rofina yasmin othman, nurzatil sharleeza mat jalaluddin, mohd salim mohamed, abdul halim ibrahim, suzana ariff azizan, mohammad firdaus abdul aziz, angelina patrick olesen, nurmadihah takhor, nazlina ibrahim, d ravichandran a/l k dhakshinamoorthy, ahmad fidhaus arham, saiful effendi syafruddin. (2025). garis panduan etika bioteknologi. - . .
yuh cai chia, sundharavalli ramayah , nurul nadia mohamad zamberi, mohamad aimanuddin mohtar , saiful effendi syafruddin. (2023). crispr/cas9: teknik penyuntingan dan modifikasi gen. - . 1.
siti nur hasanah mohd yusuf, m. aiman mohtar, saiful effendi syafruddin. (2023). penyahkawalseliaan proses transkripsi dalam patogenesis kanser. - majalah dewan kosmik. 50-53.
nur qurratu’ athirah a rahman, rahman jamal, ahmad suhail khazali, mohamad aimanuddin mohtar, saiful effendi syafruddin . (2026). dual targeting of hif-2a and klf6 suppresses angiogenic signaling in clear cell renal cell carcinoma (ccrcc). - 1st regional conference on precision health (rcph). .
haizatul umiyah nor azmi, shing cheng tan, nor azila muhammad azami, muhammad irfan abdul jalal, saiful effendi syafruddin, abdul kadir abdul karim, rahana abd rahman, chew kah teik, mohd faizal ahmad, nur azurah abdul ghani, muhammad azrai bin abu, rahman jamal. (2026). longitudinal shotgun metagenomic profiling of the vaginal microbiome in pregnant and non-pregnant malaysian women. - 1st regional confrerence on precision medicine. .
adila a hamid, nurul iffah mohd isa, amilia aminuddin, saiful effendi syafruddin, mohd faizal ahmad, mohd faizal ahmad?shahidee zainal abidin, azizah ugusman. (2026). modulation of inflammation-related genes by mir-196a-5p in endothelial cells from hypertensive pregnancies. - the annual meeting of the physiological society of japan. .
harouna issa amadou, onyeka nwosu, annah runesu takombwa, weiwen zhang, saiful effendi syafruddin, enkhchimeg vanjildorj, sirine shogheryan, galina mozgova, florian caspar rabitz, martin batic, maría florencia goberna, edian franklin franco de los santos, jocelyn cheé santiago, danilo fernández, kathleen lehmann, valeria giovannelli, margaret hunter, maria yolanda teran maigua, daphne esquivel-sada, zhaoqi ma, wei wei, emily aurand, ana atanassova, carolina torres trueba, ben novak, sarah zanon agapito, richard guy reeves, lim li ching. (2026). report of the ad hoc technical expert group on synthetic biology. - . .
mohd hafiz bin baharuddin ,saiful effendi bin syafruddin ,mohamad aimanuddin bin mohtar . (2026). comb structured wearable metamaterial with electrical conductivity for health monitoring garment of severe patients. - . .
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| FLUORESCENCE-BASED LAMP–CRISPR ASSAY FOR BLOOD-BASED SCREENING OF HIGH-RISK HPV GENOTYPES LINKED TO CERVICAL CANCER | next gene scientific sdn. bhd. | 28.7% (2025-12-01 sehingga 2027-11-30) |
| COPPER-FREE CLICK CHEMISTRY–MEDIATED CONJUGATION OF CEA/CD3 BISPECIFIC ANTIBODIES TO EXTRACELLULAR VESICLES FOR IMMUNOTHERAPEUTIC APPLICATIONS | cytonex sdn bhd | 28.7% (2025-12-01 sehingga 2027-11-30) |
BIOLOGY :PURE AND APPLIED SCIENCES
Cellular and Molecular Biology, Genomics, Genetic Engineering
Pengalaman / Experience : tahun/years(s)
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Cancer Biology
Pengalaman / Experience : tahun/years(s)
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Cancer Genetic and Epigenetic
Pengalaman / Experience : 8 tahun/years(s)
BASIC MEDICAL SCIENCES :CLINICAL AND HEALTH SCIENCES
Recombinant DNA technology and gene targeting
Pengalaman / Experience : 10 tahun/years(s)
MEDICAL MOLECULAR BIOLOGY :BASIC MEDICAL SCIENCES
CRISPR Technology, Gene Editing, Genome Engineering
Pengalaman / Experience : 10 tahun/years(s)