pensyarah universiti
institut biologi molekul perubatan ukm (umbi)
effendisy@ppukm.ukm.edu.my
Biografi/ Biography :
Saiful Effendi Syafruddin is a Research Fellow/Senior Lecturer at the UKM Medical Molecular Biology Institute (UMBI). He holds PhD in Medical Sciences from the University of Cambridge, UK. He previously earned his Master’s in Biotechnology (Molecular Genetic) from the University of Pennsylvania, USA, and BSc. in Biotechnology from Rochester Institute of Technology, USA. His PhD project focused on elucidating the genetic and epigenetic determinants that support kidney cancer pathogenesis. Saiful Effendi research interest revolves around understanding cancer molecular dependencies, specifically in kidney cancer, with the aim to identify novel and efficient clinical strategies to fight against cancer. Having been trained in the field of cell and molecular biology, cancer biology and genetic engineering for more than a decade, he has been extensively utilizing various state-of-the-art laboratory techniques throughout his cancer research works. Several of his research works have been published in high impact journals such as Nature, Cancer Discovery, Nature Communication, and Cell.
suha azizan, kim jun cheng, elsa haniffah mejia mohamed, kamariah ibrahim, farid nazer faruqu, kumutha malar vellasamy, tak loon khong , saiful effendi syafruddin, zaridatul aini ibrahim. (2024). insights into the molecular mechanisms and signalling pathways of epithelial to mesenchymal transition (emt) in colorectal cancer: a systematic review and bioinformatic analysis of gene expression. - gene. 1-14.
poh kuan wong, norazrina azmi, saiful effendi syafruddin, fook choe cheah, eng wee chua. (2024). rna sequencing reveals transcriptomic changes in hek293 cells following introduction of rs16851030 dna variant. - malaysian journal of medicine and health sciences. 49.
m. aiman mohtar, siti nur hasanah mohd yusuf, and saiful effendi syafruddin. (2024). cholesterol accumulation in ccrcc: the role of ccrcc-initiating vhl-hifa pathway. - ebiomedicine. 1-2.
ahmad mohd faizal, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu saiful effendi syafruddin, ani amelia zainuddin, nao suzuki and abdul kadir abdul karim. (2024). unravelling the role of has2, grem1, and ptgs2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis. - frontiers in endocrinology. 1-12.
nurul nadia mohamad zamberi, asmaa y abuhamad, teck yew low, m aiman mohtar, saiful effendi syafruddin. (2024). dcas9 tells tales: probing gene function and transcription regulation in cancer. - the crispr journal. 73-87.
nurul nadia mohamad zamberi, asmaa y abuhamad, teck yew low, m aiman mohtar, saiful effendi syafruddin. (2024). dcas9 tells tales: probing gene function and transcription regulation in cancer. - the crispr journal. 73-87.
ahmad mohd faizal, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu saiful effendi syafruddin, ani amelia zainuddin, nao suzuki and abdul kadir abdul karim. (2024). unravelling the role of has2, grem1, and ptgs2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis. - frontiers in endocrinology. 1-12.
suha azizan, kim jun cheng, elsa haniffah mejia mohamed, kamariah ibrahim, farid nazer faruqu, kumutha malar vellasamy, tak loon khong , saiful effendi syafruddin, zaridatul aini ibrahim. (2024). insights into the molecular mechanisms and signalling pathways of epithelial to mesenchymal transition (emt) in colorectal cancer: a systematic review and bioinformatic analysis of gene expression. - gene. 1-14.
m. aiman mohtar, siti nur hasanah mohd yusuf, and saiful effendi syafruddin. (2024). cholesterol accumulation in ccrcc: the role of ccrcc-initiating vhl-hifa pathway. - ebiomedicine. 1-2.
nurunnajah lazim, marjanu hikmah elias, zulazmi sutaji, abdul kadir abdul karim, mohammad azrai abu, azizah ugusman, saiful effendi syafruddin, mohd helmy mokhtar and mohd faizal ahmad. (2023). expression of hoxa10 gene in women with endometriosis: a systematic review. - international journal of molecular sciences. 1-14.
saiful effendi syafruddin, wan fahmi wan mohamad nazarie, nurshahirah ashikin moidu, bee hong soon, m. aiman mohtar. (2021). integration of rna-seq and proteomics data identifies glioblastoma multiforme surfaceome signature. - bmc cancer. 1-13.
nur fadhlina mohamad pakarulrazy, saiful effendi syafruddin, nurul syakima ab mutalib, azlina ahmad annuar, shen yang lim, rahman jamal, nor azian abdul murad, norlinah mohamed ibrahim. (2020). glucocerebrosidase genetic variants in malays with early and late-onset parkinson's disease. - neurology asia. 39-46.
suha azizan, kim jun cheng, elsa haniffah mejia mohamed, kamariah ibrahim, farid nazer faruqu, kumutha malar vellasamy, tak loon khong , saiful effendi syafruddin, zaridatul aini ibrahim. (2024). insights into the molecular mechanisms and signalling pathways of epithelial to mesenchymal transition (emt) in colorectal cancer: a systematic review and bioinformatic analysis of gene expression. - gene. 1-14.
nurul nadia mohamad zamberi, asmaa y abuhamad, teck yew low, m aiman mohtar, saiful effendi syafruddin. (2024). dcas9 tells tales: probing gene function and transcription regulation in cancer. - the crispr journal. 73-87.
m. aiman mohtar, siti nur hasanah mohd yusuf, and saiful effendi syafruddin. (2024). cholesterol accumulation in ccrcc: the role of ccrcc-initiating vhl-hifa pathway. - ebiomedicine. 1-2.
poh kuan wong, norazrina azmi, saiful effendi syafruddin, fook choe cheah, eng wee chua. (2024). rna sequencing reveals transcriptomic changes in hek293 cells following introduction of rs16851030 dna variant. - malaysian journal of medicine and health sciences. 49.
ahmad mohd faizal, marjanu hikmah elias, norazilah mat jin, muhammad azrai abu saiful effendi syafruddin, ani amelia zainuddin, nao suzuki and abdul kadir abdul karim. (2024). unravelling the role of has2, grem1, and ptgs2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis. - frontiers in endocrinology. 1-12.
aminah suhaila haron, saiful e. syafruddin, ilie fadzilah hashim, muggunna balasubramaniam, saw keat chuan, yasmin hasnizan, nurul syafawani fizal, chong chien fung, ana masara ahmad mokhtar. (2023). genetic disorders and rare diseases current updates. - . 16.
saiful effendi syafruddin, mohamad aimanuddin mohtar, tan shing cheng, nadiah abu, nor aidatulakma abdullah@muda, nurul syakima ab mutalib, chin siok fong, neoh hui min, rahman jamal, nor azian abdul murad. (2019). malaysian higher institution centres of excellence (hicoe) official compendium. - . 244.
mohamad aimanuddin bin mohtar;saiful effendi bin syafruddin;low teck yew. (2024). elucidating the secretome of crispr/cas9 mediated agr2-knockout breast cancer cells. - . .
nur syakirah othman, adila a. hamid, amilia aminuddin, farah hanan fathihah jaffar, shahidee zainal abidin, saiful effendi syafruddin, norfilza mohd mokhtar, mohd faizal ahmad, azizah ugusman. (2023). in silico prediction and validation of pi3kca as the target of novel mir- 1133 in human umbilical vein endothelial cells exposed to hyperglycemia. - the 10th federation of the asian and oceanian physiological societies congress (faops) 2023. 188.
ahmad rifqi bin md zain;tengku hasnan bin tengku abdul aziz;saiful effendi bin syafruddin;mohamad aimanuddin bin mohtar. (2023). optical sensor technique based on high quality factor suspended 1d photonic crystal (phc) structures for creatinine detection using non-invasive approach.. - . .
yuh cai chia, sundharavalli ramayah , nurul nadia mohamad zamberi, mohamad aimanuddin mohtar , saiful effendi syafruddin. (2023). crispr/cas9: teknik penyuntingan dan modifikasi gen. - . 1.
syazalina zahari, saiful effendi syafruddin, low teck yew, delphine fessart, tiannan guo, m. aiman mohtar. (2023). high throughput dia-nn proteomics identifies altered extracellular protein network in crispr- targeted agr2 of breast cancer cells. - 9th regional conference on molecular medicine (rcmm) in conjunction with 5th national conference for cancer research (nccr). 1-19.
| Geran / Grant | Kolaborator / Collaborator | Status |
|---|---|---|
| ELUCIDATING THE CROSSTALK BETWEEN HIF2α-VEGFA AND KLF6-PDGFβ AXES IN DRIVING RENAL CARCINOMA HYPERVASCULARIZATION | nanoarms sdn. bhd. | 61.2% (2023-10-01 sehingga 2025-09-30) |
| ELUCIDATING THE CROSSTALK BETWEEN HIF2α-VEGFA AND KLF6-PDGFβ AXES IN DRIVING RENAL CARCINOMA HYPERVASCULARIZATION | genomax technologies sdn bhd | 61.2% (2023-10-01 sehingga 2025-09-30) |
| COMB STRUCTURED WEARABLE METAMATERIAL WITH ELECTRICAL CONDUCTIVITY FOR HEALTH MONITORING GARMENT OF SEVERE PATIENTS | kelisa technology sdn bhd | 94.6% (2021-09-01 sehingga 2025-02-28) |
| ELUCIDATING THE GREM1, HAS2 AND PTGS2 GENE EXPRESSION AS OOCYTES DEVELOPMENT COMPETENCY MARKERS AMONG WOMEN WITH POOR OVARIAN RESERVE (POR) FOLLOWING THE IN VITRO MATURATION (IVM) | haczen sdn. bhd | 94.1% (2021-09-07 sehingga 2025-03-06) |